(64 nodes) Mixed, incl. BLOC complex, and Melanosome organization network (Cynoglossus semilaevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSCSEP00000000296	GOLD domain-containing protein. (149 aa)
	ENSCSEP00000000301	RUN domain-containing protein. (524 aa)
	LOC103398115	Chemokine (C motif) receptor 1a, duplicate 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
	LOC103384558	AAA domain-containing protein. (2221 aa)
	slc45a2	Solute carrier family 45 member 2. (619 aa)
	hps3	HPS3 biogenesis of lysosomal organelles complex 2 subunit 1. (1053 aa)
	rab32	RAB32a, member RAS oncogene family. (314 aa)
	luzp2	Leucine zipper protein 2. (350 aa)
	borcs5	BLOC-1 related complex subunit 5. (197 aa)
	LOC103387072	Interleukin 22 receptor, alpha 2. (227 aa)
	ENSCSEP00000006487	Premelanosome protein a. (665 aa)
	slc10a7	Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (346 aa)
	bloc1s2	Biogenesis of lysosomal organelles complex-1, subunit 2. (169 aa)
	slc24a5	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (424 aa)
	borcs6	Si:dkey-72l14.4. (448 aa)
	kxd1	KxDL motif containing 1. (180 aa)
	gas2	Growth arrest-specific 2a. (343 aa)
	LOC103383745	Tyrosinase-related protein 1b. (533 aa)
	hps1	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (671 aa)
	hps5	Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1155 aa)
	LOC103390683	Tyrosinase related protein 1. (521 aa)
	borcs8	BLOC-1 related complex subunit 8. (128 aa)
	Mc1r	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (312 aa)
	LOC103399368	Uncharacterized protein. (107 aa)
	HPS6	Uncharacterized protein. (851 aa)
	LOC103388562	Solute carrier family 45 member 4b. (806 aa)
	bloc1s5	Biogenesis of lysosomal organelles complex-1, subunit 5, muted. (155 aa)
	dct	Dopachrome tautomerase. (516 aa)
	LOC103388717	Uncharacterized protein. (346 aa)
	ENSCSEP00000017038	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (563 aa)
	slc24a3	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (549 aa)
	bloc1s6	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (167 aa)
	foxd1	Forkhead box D1. (371 aa)
	LOC103396406	FYVE and coiled-coil domain containing 1b. (1426 aa)
	ENSCSEP00000020569	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (297 aa)
	LOC103386496	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (212 aa)
	LOC103393008	Uncharacterized protein. (252 aa)
	SLC45A4	Solute carrier family 45 member 4. (887 aa)
	snapin	SNAP associated protein. (129 aa)
	slc10a2	Solute carrier family 10 member 2. (356 aa)
	LOC103386534	Neuron navigator 1b. (2126 aa)
	MLANA	Uncharacterized protein. (120 aa)
	ENSCSEP00000026319	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (622 aa)
	borcs7	BLOC-1 related complex subunit 7. (80 aa)
	ENSCSEP00000026451	Solute carrier family 2 member 15a; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (529 aa)
	LOC103395386	RAB38b, member of RAS oncogene family. (218 aa)
	dtnbp1	Dystrobrevin binding protein 1b. (234 aa)
	LOC103394410	Biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino. (249 aa)
	LOC103384476	Zgc:162171. (364 aa)
	stmnd1	Uncharacterized protein. (336 aa)
	LOC103378511	Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). Belongs to the BLOC1S3 family. (195 aa)
	MITF	Melanocyte inducing transcription factor b. (577 aa)
	LOC103384461	ADP-ribosylation factor-like 8A; Belongs to the small GTPase superfamily. Arf family. (176 aa)
	tyr	Tyrosinase. (574 aa)
	bloc1s1	Biogenesis of lysosomal organelles complex-1, subunit 1. (126 aa)
	LOC103395521	RAB38c, member of RAS oncogene family. (208 aa)
	ENSCSEP00000030877	CDC42 effector protein (Rho GTPase binding) 1a. (319 aa)
	asip	Agouti domain-containing protein. (124 aa)
	ENSCSEP00000031603	Uncharacterized protein. (237 aa)
	herc3	HECT and RLD domain containing E3 ubiquitin protein ligase 3. (1046 aa)
	ENSCSEP00000033739	Leucine-rich repeat kinase 2. (2316 aa)
	slc45a1	Solute carrier family 45 member 1. (803 aa)
	arl8b	ADP-ribosylation factor-like 8Ba; Belongs to the small GTPase superfamily. Arf family. (186 aa)
	slc10a3	Solute carrier family 10 member 3. (474 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSEP00000000296	ENSCSEP00000000301	ENSCSEP00000000296	ENSCSEP00000000301	GOLD domain-containing protein.	RUN domain-containing protein.	0.899
ENSCSEP00000000296	LOC103396406	ENSCSEP00000000296	ENSCSEP00000020543	GOLD domain-containing protein.	FYVE and coiled-coil domain containing 1b.	0.900
ENSCSEP00000000301	ENSCSEP00000000296	ENSCSEP00000000301	ENSCSEP00000000296	RUN domain-containing protein.	GOLD domain-containing protein.	0.899
ENSCSEP00000006487	LOC103383745	ENSCSEP00000006487	ENSCSEP00000009761	Premelanosome protein a.	Tyrosinase-related protein 1b.	0.527
ENSCSEP00000006487	LOC103390683	ENSCSEP00000006487	ENSCSEP00000010396	Premelanosome protein a.	Tyrosinase related protein 1.	0.527
ENSCSEP00000006487	MITF	ENSCSEP00000006487	ENSCSEP00000028880	Premelanosome protein a.	Melanocyte inducing transcription factor b.	0.437
ENSCSEP00000006487	MLANA	ENSCSEP00000006487	ENSCSEP00000026197	Premelanosome protein a.	Uncharacterized protein.	0.882
ENSCSEP00000006487	Mc1r	ENSCSEP00000006487	ENSCSEP00000010937	Premelanosome protein a.	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family.	0.452
ENSCSEP00000006487	dct	ENSCSEP00000006487	ENSCSEP00000015124	Premelanosome protein a.	Dopachrome tautomerase.	0.602
ENSCSEP00000006487	slc24a5	ENSCSEP00000006487	ENSCSEP00000008742	Premelanosome protein a.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.586
ENSCSEP00000006487	slc45a1	ENSCSEP00000006487	ENSCSEP00000033771	Premelanosome protein a.	Solute carrier family 45 member 1.	0.500
ENSCSEP00000006487	slc45a2	ENSCSEP00000006487	ENSCSEP00000001169	Premelanosome protein a.	Solute carrier family 45 member 2.	0.507
ENSCSEP00000006487	tyr	ENSCSEP00000006487	ENSCSEP00000029417	Premelanosome protein a.	Tyrosinase.	0.562
ENSCSEP00000017038	HPS6	ENSCSEP00000017038	ENSCSEP00000012631	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	Uncharacterized protein.	0.669
ENSCSEP00000017038	LOC103378511	ENSCSEP00000017038	ENSCSEP00000028590	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). Belongs to the BLOC1S3 family.	0.477
ENSCSEP00000017038	LOC103384476	ENSCSEP00000017038	ENSCSEP00000027960	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	Zgc:162171.	0.530
ENSCSEP00000017038	LOC103395386	ENSCSEP00000017038	ENSCSEP00000026908	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	RAB38b, member of RAS oncogene family.	0.530
ENSCSEP00000017038	LOC103395521	ENSCSEP00000017038	ENSCSEP00000030794	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	RAB38c, member of RAS oncogene family.	0.530
ENSCSEP00000017038	LOC103399368	ENSCSEP00000017038	ENSCSEP00000011454	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	Uncharacterized protein.	0.477
ENSCSEP00000017038	Mc1r	ENSCSEP00000017038	ENSCSEP00000010937	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family.	0.605