node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC103380153 | LOC103382819 | ENSCSEP00000009133 | ENSCSEP00000015663 | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.900 |
LOC103380153 | rnf4 | ENSCSEP00000009133 | ENSCSEP00000008386 | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. | RING-type domain-containing protein. | 0.887 |
LOC103380153 | rnf8 | ENSCSEP00000009133 | ENSCSEP00000032366 | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.949 |
LOC103380153 | ube2v2 | ENSCSEP00000009133 | ENSCSEP00000016032 | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-conjugating enzyme E2 variant 2. | 0.902 |
LOC103382819 | LOC103380153 | ENSCSEP00000015663 | ENSCSEP00000009133 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. | 0.900 |
LOC103382819 | rnf4 | ENSCSEP00000015663 | ENSCSEP00000008386 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | RING-type domain-containing protein. | 0.887 |
LOC103382819 | rnf8 | ENSCSEP00000015663 | ENSCSEP00000032366 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.949 |
LOC103382819 | ube2v2 | ENSCSEP00000015663 | ENSCSEP00000016032 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-conjugating enzyme E2 variant 2. | 0.902 |
rnf4 | LOC103380153 | ENSCSEP00000008386 | ENSCSEP00000009133 | RING-type domain-containing protein. | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. | 0.887 |
rnf4 | LOC103382819 | ENSCSEP00000008386 | ENSCSEP00000015663 | RING-type domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.887 |
rnf4 | rnf8 | ENSCSEP00000008386 | ENSCSEP00000032366 | RING-type domain-containing protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.523 |
rnf4 | ube2v2 | ENSCSEP00000008386 | ENSCSEP00000016032 | RING-type domain-containing protein. | Ubiquitin-conjugating enzyme E2 variant 2. | 0.599 |
rnf8 | LOC103380153 | ENSCSEP00000032366 | ENSCSEP00000009133 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. | 0.949 |
rnf8 | LOC103382819 | ENSCSEP00000032366 | ENSCSEP00000015663 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.949 |
rnf8 | rnf4 | ENSCSEP00000032366 | ENSCSEP00000008386 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | RING-type domain-containing protein. | 0.523 |
rnf8 | ube2v2 | ENSCSEP00000032366 | ENSCSEP00000016032 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | Ubiquitin-conjugating enzyme E2 variant 2. | 0.798 |
ube2v2 | LOC103380153 | ENSCSEP00000016032 | ENSCSEP00000009133 | Ubiquitin-conjugating enzyme E2 variant 2. | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. | 0.902 |
ube2v2 | LOC103382819 | ENSCSEP00000016032 | ENSCSEP00000015663 | Ubiquitin-conjugating enzyme E2 variant 2. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.902 |
ube2v2 | rnf4 | ENSCSEP00000016032 | ENSCSEP00000008386 | Ubiquitin-conjugating enzyme E2 variant 2. | RING-type domain-containing protein. | 0.599 |
ube2v2 | rnf8 | ENSCSEP00000016032 | ENSCSEP00000032366 | Ubiquitin-conjugating enzyme E2 variant 2. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.798 |