5 items (Cynoglossus semilaevis) - STRING interaction network

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Your Input:
	rnf4	RING-type domain-containing protein. (246 aa)
	LOC103380153	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	LOC103382819	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	ube2v2	Ubiquitin-conjugating enzyme E2 variant 2. (158 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103380153	LOC103382819	ENSCSEP00000009133	ENSCSEP00000015663	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.900
LOC103380153	rnf4	ENSCSEP00000009133	ENSCSEP00000008386	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	RING-type domain-containing protein.	0.887
LOC103380153	rnf8	ENSCSEP00000009133	ENSCSEP00000032366	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.949
LOC103380153	ube2v2	ENSCSEP00000009133	ENSCSEP00000016032	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2 variant 2.	0.902
LOC103382819	LOC103380153	ENSCSEP00000015663	ENSCSEP00000009133	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.900
LOC103382819	rnf4	ENSCSEP00000015663	ENSCSEP00000008386	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	RING-type domain-containing protein.	0.887
LOC103382819	rnf8	ENSCSEP00000015663	ENSCSEP00000032366	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.949
LOC103382819	ube2v2	ENSCSEP00000015663	ENSCSEP00000016032	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2 variant 2.	0.902
rnf4	LOC103380153	ENSCSEP00000008386	ENSCSEP00000009133	RING-type domain-containing protein.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.887
rnf4	LOC103382819	ENSCSEP00000008386	ENSCSEP00000015663	RING-type domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.887
rnf4	rnf8	ENSCSEP00000008386	ENSCSEP00000032366	RING-type domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.523
rnf4	ube2v2	ENSCSEP00000008386	ENSCSEP00000016032	RING-type domain-containing protein.	Ubiquitin-conjugating enzyme E2 variant 2.	0.599
rnf8	LOC103380153	ENSCSEP00000032366	ENSCSEP00000009133	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.949
rnf8	LOC103382819	ENSCSEP00000032366	ENSCSEP00000015663	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.949
rnf8	rnf4	ENSCSEP00000032366	ENSCSEP00000008386	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	RING-type domain-containing protein.	0.523
rnf8	ube2v2	ENSCSEP00000032366	ENSCSEP00000016032	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Ubiquitin-conjugating enzyme E2 variant 2.	0.798
ube2v2	LOC103380153	ENSCSEP00000016032	ENSCSEP00000009133	Ubiquitin-conjugating enzyme E2 variant 2.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.902
ube2v2	LOC103382819	ENSCSEP00000016032	ENSCSEP00000015663	Ubiquitin-conjugating enzyme E2 variant 2.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.902
ube2v2	rnf4	ENSCSEP00000016032	ENSCSEP00000008386	Ubiquitin-conjugating enzyme E2 variant 2.	RING-type domain-containing protein.	0.599
ube2v2	rnf8	ENSCSEP00000016032	ENSCSEP00000032366	Ubiquitin-conjugating enzyme E2 variant 2.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.798