14 items (Cynoglossus semilaevis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	mthfd1	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (934 aa)
	tyms	Thymidylate synthetase. (440 aa)
	ENSCSEP00000004588	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (879 aa)
	gart	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1027 aa)
	mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (655 aa)
	shmt1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (466 aa)
	mthfs	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (203 aa)
	mtfmt	Mitochondrial methionyl-tRNA formyltransferase. (369 aa)
	ftcd	Formimidoyltransferase cyclodeaminase. (540 aa)
	Fpgs	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (576 aa)
	LOC103380400	Zgc:153031. (196 aa)
	LOC103397081	Uncharacterized protein. (338 aa)
	dhfr	Dihydrofolate reductase. (189 aa)
	LOC103397730	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (411 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSEP00000004588	Fpgs	ENSCSEP00000004588	ENSCSEP00000015391	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.943
ENSCSEP00000004588	LOC103380400	ENSCSEP00000004588	ENSCSEP00000015533	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Zgc:153031.	0.958
ENSCSEP00000004588	LOC103397081	ENSCSEP00000004588	ENSCSEP00000017681	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Uncharacterized protein.	0.979
ENSCSEP00000004588	LOC103397730	ENSCSEP00000004588	ENSCSEP00000031458	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.979
ENSCSEP00000004588	dhfr	ENSCSEP00000004588	ENSCSEP00000024916	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Dihydrofolate reductase.	0.959
ENSCSEP00000004588	ftcd	ENSCSEP00000004588	ENSCSEP00000014049	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Formimidoyltransferase cyclodeaminase.	0.975
ENSCSEP00000004588	gart	ENSCSEP00000004588	ENSCSEP00000006192	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.999
ENSCSEP00000004588	mtfmt	ENSCSEP00000004588	ENSCSEP00000013446	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Mitochondrial methionyl-tRNA formyltransferase.	0.768
ENSCSEP00000004588	mthfd1	ENSCSEP00000004588	ENSCSEP00000000230	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b.	0.902
ENSCSEP00000004588	mthfr	ENSCSEP00000004588	ENSCSEP00000007478	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.781
ENSCSEP00000004588	mthfs	ENSCSEP00000004588	ENSCSEP00000010517	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.	0.809
ENSCSEP00000004588	shmt1	ENSCSEP00000004588	ENSCSEP00000009832	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.985
ENSCSEP00000004588	tyms	ENSCSEP00000004588	ENSCSEP00000000586	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Thymidylate synthetase.	0.666
Fpgs	ENSCSEP00000004588	ENSCSEP00000015391	ENSCSEP00000004588	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.943
Fpgs	LOC103380400	ENSCSEP00000015391	ENSCSEP00000015533	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Zgc:153031.	0.992
Fpgs	LOC103397081	ENSCSEP00000015391	ENSCSEP00000017681	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Uncharacterized protein.	0.939
Fpgs	LOC103397730	ENSCSEP00000015391	ENSCSEP00000031458	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.939
Fpgs	dhfr	ENSCSEP00000015391	ENSCSEP00000024916	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Dihydrofolate reductase.	0.994
Fpgs	gart	ENSCSEP00000015391	ENSCSEP00000006192	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.734
Fpgs	mtfmt	ENSCSEP00000015391	ENSCSEP00000013446	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	Mitochondrial methionyl-tRNA formyltransferase.	0.685