(87 nodes) Regulation of BMP signaling pathway network (Cynoglossus semilaevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NBL1	NBL1, DAN family BMP antagonist. (235 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (186 aa)
	LOC103377530	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (403 aa)
	rnf165	Ring finger protein 165a. (343 aa)
	ENSCSEP00000002088	Hemojuvelin BMP co-receptor. (328 aa)
	LOC103383464	Metalloendopeptidase. (1025 aa)
	ctdspl2	CTD small phosphatase like 2. (475 aa)
	bmp2	Bone morphogenetic protein 2. (422 aa)
	nog	Noggin; Belongs to the noggin family. (224 aa)
	fstl3	Follistatin-like 3 (secreted glycoprotein). (248 aa)
	LOC103399922	RGM domain family, member D. (455 aa)
	LOC103384737	V-ski avian sarcoma viral oncogene homolog a. (736 aa)
	tnfaip6	Tumor necrosis factor, alpha-induced protein 6. (263 aa)
	LOC103381185	Gremlin 1a, DAN family BMP antagonist. (182 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	ENSCSEP00000006313	VWFD domain-containing protein. (202 aa)
	ENSCSEP00000006330	Uncharacterized protein. (989 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1059 aa)
	Sorl1	Sortilin-related receptor, L(DLR class) A repeats containing. (2094 aa)
	grem2	Gremlin 2, DAN family BMP antagonist a. (167 aa)
	chrd	Chordin. (882 aa)
	fkbp8	Peptidylprolyl isomerase. (404 aa)
	gdf5	Growth differentiation factor 5. (652 aa)
	smurf1	E3 ubiquitin-protein ligase. (729 aa)
	sfrp5	Secreted frizzled-related protein 5. (319 aa)
	ENSCSEP00000010572	Kazal-like domain-containing protein. (88 aa)
	LOC103397887	Mothers against decapentaplegic homolog. (510 aa)
	smad6	Mothers against decapentaplegic homolog. (491 aa)
	ENSCSEP00000011075	Uncharacterized protein. (187 aa)
	skor1	SKI family transcriptional corepressor 1b. (737 aa)
	msx1	Muscle segment homeobox 1a. (284 aa)
	ILK	Integrin linked kinase. (452 aa)
	LOC103380347	Sizzled. (283 aa)
	ENSCSEP00000011989	RGM_C domain-containing protein. (177 aa)
	ENSCSEP00000012019	TB domain-containing protein. (86 aa)
	ENSCSEP00000012566	Uncharacterized protein. (130 aa)
	ENSCSEP00000012708	annotation not available (68 aa)
	UBE2O	Ubiquitin conjugating enzyme E2 O. (1359 aa)
	LOC103395087	Integrin linked kinase. (452 aa)
	GDF6	Growth differentiation factor 6. (441 aa)
	LOC103396974	RING-type domain-containing protein. (345 aa)
	bmper	BMP binding endothelial regulator. (716 aa)
	LOC103383976	E3 ubiquitin-protein ligase. (777 aa)
	LOC103378171	Spartin b. (603 aa)
	LOC103376967	Forkhead box H1. (519 aa)
	vwc2l	Von Willebrand factor C domain containing 2 like. (228 aa)
	spart	Spartin a. (631 aa)
	LOC103379083	Mothers against decapentaplegic homolog. (548 aa)
	LOC103380497	FCP1 homology domain-containing protein. (478 aa)
	ENSCSEP00000020285	SKI family transcriptional corepressor 1. (788 aa)
	LOC103397185	Metalloendopeptidase. (962 aa)
	LOC103384177	DAN domain family, member 5. (260 aa)
	LOC103391130	Mothers against decapentaplegic homolog. (473 aa)
	LOC103397412	Secreted frizzled-related protein 1a. (299 aa)
	LOC103379458	Peptidylprolyl isomerase. (488 aa)
	LOC103384195	HtrA serine peptidase 3a. (498 aa)
	LOC103377099	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	ENSCSEP00000021801	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a. (145 aa)
	LOC103393707	SMAD specific E3 ubiquitin protein ligase 2. (794 aa)
	ENSCSEP00000022461	C2 domain-containing protein. (54 aa)
	LOC103396454	SKI-like proto-oncogene a. (766 aa)
	sostdc1	Sclerostin domain containing 1a. (221 aa)
	LOC103398239	Metalloendopeptidase. (975 aa)
	LOC103394304	Mothers against decapentaplegic homolog. (573 aa)
	LOC103387688	Dickkopf WNT signaling pathway inhibitor 1a. (253 aa)
	ENSCSEP00000025647	LEM domain containing 3. (763 aa)
	ENSCSEP00000026136	CA domain-containing protein. (166 aa)
	ENSCSEP00000026144	Cadherin_C domain-containing protein; Cadherins are calcium-dependent cell adhesion proteins. (236 aa)
	twsg1	Twisted gastrulation BMP signaling modulator 1. (224 aa)
	SMAD4	Mothers against decapentaplegic homolog. (503 aa)
	fbxl15	F-box and leucine-rich repeat protein 15. (293 aa)
	LOC103397655	Ring finger protein 165b. (457 aa)
	LOC103395909	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 3. (372 aa)
	LOC103394470	CTCK domain-containing protein. (225 aa)
	ccn1	Cellular communication network factor 1. (376 aa)
	LOC103381988	Noggin; Belongs to the noggin family. (209 aa)
	ENSCSEP00000029544	Uncharacterized protein. (2238 aa)
	LOC103378548	Uncharacterized protein. (343 aa)
	LOC103384498	Hairy-related 12. (164 aa)
	itga3	Integrin, alpha 3b; Belongs to the integrin alpha chain family. (1076 aa)
	smad7	Mothers against decapentaplegic homolog. (376 aa)
	Skor2	SKI family transcriptional corepressor 2. (671 aa)
	fst	Uncharacterized protein. (328 aa)
	Chrdl1	Chordin-like 2. (477 aa)
	ENSCSEP00000032108	Noggin; Belongs to the noggin family. (215 aa)
	LOC103385452	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5. (386 aa)
	ENSCSEP00000033853	V-ski avian sarcoma viral oncogene homolog b. (658 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Chrdl1	bmp2	ENSCSEP00000031582	ENSCSEP00000003367	Chordin-like 2.	Bone morphogenetic protein 2.	0.493
Chrdl1	twsg1	ENSCSEP00000031582	ENSCSEP00000026264	Chordin-like 2.	Twisted gastrulation BMP signaling modulator 1.	0.416
ENSCSEP00000002088	bmp2	ENSCSEP00000002088	ENSCSEP00000003367	Hemojuvelin BMP co-receptor.	Bone morphogenetic protein 2.	0.563
ENSCSEP00000006313	ENSCSEP00000006330	ENSCSEP00000006313	ENSCSEP00000006330	VWFD domain-containing protein.	Uncharacterized protein.	0.756
ENSCSEP00000006330	ENSCSEP00000006313	ENSCSEP00000006330	ENSCSEP00000006313	Uncharacterized protein.	VWFD domain-containing protein.	0.756
ENSCSEP00000011989	bmp2	ENSCSEP00000011989	ENSCSEP00000003367	RGM_C domain-containing protein.	Bone morphogenetic protein 2.	0.563
ENSCSEP00000012566	itga3	ENSCSEP00000012566	ENSCSEP00000030643	Uncharacterized protein.	Integrin, alpha 3b; Belongs to the integrin alpha chain family.	0.900
ENSCSEP00000021801	LOC103379083	ENSCSEP00000021801	ENSCSEP00000019746	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a.	Mothers against decapentaplegic homolog.	0.630
ENSCSEP00000021801	LOC103391130	ENSCSEP00000021801	ENSCSEP00000021439	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a.	Mothers against decapentaplegic homolog.	0.445
ENSCSEP00000021801	LOC103394304	ENSCSEP00000021801	ENSCSEP00000024049	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a.	Mothers against decapentaplegic homolog.	0.476
ENSCSEP00000021801	LOC103397887	ENSCSEP00000021801	ENSCSEP00000010634	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a.	Mothers against decapentaplegic homolog.	0.476
ENSCSEP00000021801	SMAD4	ENSCSEP00000021801	ENSCSEP00000026341	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a.	Mothers against decapentaplegic homolog.	0.476
ENSCSEP00000021801	bmpr2	ENSCSEP00000021801	ENSCSEP00000006835	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.475
ENSCSEP00000021801	smad6	ENSCSEP00000021801	ENSCSEP00000010996	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a.	Mothers against decapentaplegic homolog.	0.630
ENSCSEP00000021801	smad7	ENSCSEP00000021801	ENSCSEP00000031014	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a.	Mothers against decapentaplegic homolog.	0.630
ENSCSEP00000022461	LOC103379083	ENSCSEP00000022461	ENSCSEP00000019746	C2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.782
ENSCSEP00000022461	LOC103391130	ENSCSEP00000022461	ENSCSEP00000021439	C2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.648
ENSCSEP00000022461	LOC103394304	ENSCSEP00000022461	ENSCSEP00000024049	C2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.645
ENSCSEP00000022461	LOC103397887	ENSCSEP00000022461	ENSCSEP00000010634	C2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.645
ENSCSEP00000022461	SMAD4	ENSCSEP00000022461	ENSCSEP00000026341	C2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.645