(108 nodes) Hindbrain development network (Cynoglossus semilaevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103379770	RPGRIP1 like. (1011 aa)
	LOC103385960	Vang-like protein. (528 aa)
	LOC103396120	Orthodenticle homeobox 2b. (290 aa)
	wdr73	Uncharacterized protein. (384 aa)
	LOC103377530	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (403 aa)
	ENSCSEP00000002069	ATP/GTP binding protein-like 1. (1016 aa)
	rnf152	Ring finger protein 152. (174 aa)
	znf503	Zinc finger protein 503. (586 aa)
	ENSCSEP00000003216	Homeobox domain-containing protein. (297 aa)
	LOC103399842	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. (889 aa)
	LOC103377634	RNA binding motif protein 7. (268 aa)
	bmp2	Bone morphogenetic protein 2. (422 aa)
	ENSCSEP00000003481	Si:ch211-160f23.7. (233 aa)
	nog	Noggin; Belongs to the noggin family. (224 aa)
	SNX14	Sorting nexin 14. (940 aa)
	LOC103381071	Si:ch73-21k16.5; Belongs to the GPAT/DAPAT family. (687 aa)
	LOC103390580	Mediator complex subunit 12. (2101 aa)
	Gnpat	Glyceronephosphate O-acyltransferase; Belongs to the GPAT/DAPAT family. (670 aa)
	gsx2	GS homeobox 2. (257 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (305 aa)
	mpp5	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (650 aa)
	ENSCSEP00000005784	Uncharacterized protein. (123 aa)
	sez6	Seizure related 6 homolog b. (953 aa)
	ENSCSEP00000007014	LIM zinc-binding domain-containing protein. (60 aa)
	LOC103377735	LIM homeobox 1a. (316 aa)
	phox2b	Paired like homeobox 2Bb. (285 aa)
	ascl1	Achaete-scute family bHLH transcription factor 1a. (189 aa)
	LOC103387228	Paired box 2a. (372 aa)
	klhl5	Kelch-like family member 5. (790 aa)
	LOC103388995	Cytochrome P450, family 26, subfamily b, polypeptide 1; Belongs to the cytochrome P450 family. (512 aa)
	atf5	BZIP domain-containing protein. (505 aa)
	ENSCSEP00000007811	Paired box 5. (411 aa)
	arl13b	ADP-ribosylation factor-like 13b. (408 aa)
	LOC103377807	CRK proto-oncogene, adaptor protein. (315 aa)
	serpine2	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (396 aa)
	rest	RE1-silencing transcription factor. (962 aa)
	ENSCSEP00000009162	Sorting nexin 14. (456 aa)
	ENSCSEP00000009170	Uncharacterized protein. (110 aa)
	cep55	Centrosomal protein 55 like. (486 aa)
	ahi1	Abelson helper integration site 1. (1202 aa)
	ttll1	Tubulin tyrosine ligase-like family, member 1. (424 aa)
	epha4	Eph receptor A4, like. (989 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (248 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	ENSCSEP00000011915	SRRM_C domain-containing protein. (395 aa)
	bmi1	RAWUL domain-containing protein. (144 aa)
	clp1	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (441 aa)
	ttc21b	Tetratricopeptide repeat domain 21B. (1317 aa)
	ENSCSEP00000013420	Paired box 4. (231 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (819 aa)
	en1	Homeobox protein engrailed-like. (251 aa)
	LOC103389863	Gastrulation brain homeobox 2. (344 aa)
	lef1	Lymphoid enhancer-binding factor 1. (361 aa)
	LOC103397455	Zinc finger protein 703. (594 aa)
	KNDC1	Kinase non-catalytic C-lobe domain containing 1. (1756 aa)
	LOC103393941	Cyclin-dependent kinase 5 activator. (334 aa)
	naglu	N-acetylglucosaminidase, alpha. (803 aa)
	ENSCSEP00000017308	Uncharacterized protein. (251 aa)
	cdk5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	rfng	Beta-1,3-N-acetylglucosaminyltransferase. (406 aa)
	ENSCSEP00000017534	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (550 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (911 aa)
	LOC103381669	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (488 aa)
	sez6l	Seizure related 6 homolog (mouse)-like. (1006 aa)
	egr2	Early growth response 2b. (453 aa)
	ENSCSEP00000018043	Uncharacterized protein. (77 aa)
	ENSCSEP00000018130	Uncharacterized protein. (712 aa)
	LOC103391049	Kelch-like family member 4. (745 aa)
	ENSCSEP00000019257	X-ray repair complementing defective repair in Chinese hamster cells 1. (567 aa)
	agtpbp1	ATP/GTP binding protein 1. (1255 aa)
	ENSCSEP00000019637	Growth arrest-specific 1b. (240 aa)
	LOC103391098	Neurogenin 1. (198 aa)
	mib1	Mindbomb E3 ubiquitin protein ligase 1. (1041 aa)
	abl2	Tyrosine-protein kinase. (1211 aa)
	LOC103392966-2	Seizure related 6 homolog (mouse)-like 2. (875 aa)
	ENSCSEP00000022206	C2H2-type domain-containing protein. (560 aa)
	hnf1b	HNF1 homeobox Ba. (623 aa)
	prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (588 aa)
	pax6	Paired box 6b. (456 aa)
	LOC103378264	Coenzyme Q8B. (480 aa)
	LOC103381863	Cyclin-dependent kinase 5 activator. (317 aa)
	whrn	Whirlin a. (984 aa)
	efnb2	Ephrin-B2a; Belongs to the ephrin family. (345 aa)
	Kif14	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1619 aa)
	LOC103393664	Uncharacterized protein. (295 aa)
	LOC103395373	Uncharacterized protein. (319 aa)
	MPP5	Membrane palmitoylated protein 5; Belongs to the MAGUK family. (665 aa)
	pdss2	Prenyl (decaprenyl) diphosphate synthase, subunit 2. (858 aa)
	abl1	Tyrosine-protein kinase. (1113 aa)
	LOC103384377	MBD domain-containing protein. (1215 aa)
	ENSCSEP00000027160	Paired box 2b. (391 aa)
	hspa5	Heat shock protein 5; Belongs to the heat shock protein 70 family. (655 aa)
	ENSCSEP00000028290	Uncharacterized protein. (650 aa)
	pax8	Paired box 8. (466 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (533 aa)
	phox2a	Paired like homeobox 2A. (301 aa)
	LOC103389210	POU domain protein. (476 aa)
	ENSCSEP00000030469	C2-C2_1 domain-containing protein. (608 aa)
	Cdk5r2	Cyclin-dependent kinase 5 activator. (319 aa)
	ENSCSEP00000031320	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
	LOC103391414	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	ENSCSEP00000032689	Serine/arginine repetitive matrix 4. (511 aa)
	MAFB	MAF bZIP transcription factor B. (389 aa)
	LOC103379523	Uncharacterized protein. (526 aa)
	ptf1a	Pancreas associated transcription factor 1a. (300 aa)
	Chmp1a	Charged multivesicular body protein 1A. (198 aa)
	VANGL2	Vang-like protein. (525 aa)
	NCSTN	Nicastrin. (700 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH2	LOC103399842	ENSCSEP00000017607	ENSCSEP00000003218	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins.	0.901
Cdk5r2	cdk5	ENSCSEP00000030817	ENSCSEP00000017339	Cyclin-dependent kinase 5 activator.	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	0.927
ENSCSEP00000003216	LOC103389210	ENSCSEP00000003216	ENSCSEP00000029933	Homeobox domain-containing protein.	POU domain protein.	0.433
ENSCSEP00000005784	LOC103385960	ENSCSEP00000005784	ENSCSEP00000000280	Uncharacterized protein.	Vang-like protein.	0.454
ENSCSEP00000005784	VANGL2	ENSCSEP00000005784	ENSCSEP00000033212	Uncharacterized protein.	Vang-like protein.	0.454
ENSCSEP00000013420	LOC103391098	ENSCSEP00000013420	ENSCSEP00000019907	Paired box 4.	Neurogenin 1.	0.424
ENSCSEP00000017308	ENSCSEP00000019637	ENSCSEP00000017308	ENSCSEP00000019637	Uncharacterized protein.	Growth arrest-specific 1b.	0.905
ENSCSEP00000017308	LOC103377530	ENSCSEP00000017308	ENSCSEP00000001420	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.506
ENSCSEP00000017308	smo	ENSCSEP00000017308	ENSCSEP00000014291	Uncharacterized protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.436
ENSCSEP00000018043	bmi1	ENSCSEP00000018043	ENSCSEP00000012054	Uncharacterized protein.	RAWUL domain-containing protein.	0.789
ENSCSEP00000019637	ENSCSEP00000017308	ENSCSEP00000019637	ENSCSEP00000017308	Growth arrest-specific 1b.	Uncharacterized protein.	0.905
ENSCSEP00000019637	LOC103377530	ENSCSEP00000019637	ENSCSEP00000001420	Growth arrest-specific 1b.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.506
ENSCSEP00000019637	smo	ENSCSEP00000019637	ENSCSEP00000014291	Growth arrest-specific 1b.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.436
ENSCSEP00000028290	ENSCSEP00000030469	ENSCSEP00000028290	ENSCSEP00000030469	Uncharacterized protein.	C2-C2_1 domain-containing protein.	0.590
ENSCSEP00000028290	LOC103379770	ENSCSEP00000028290	ENSCSEP00000033919	Uncharacterized protein.	RPGRIP1 like.	0.590
ENSCSEP00000028290	ahi1	ENSCSEP00000028290	ENSCSEP00000010330	Uncharacterized protein.	Abelson helper integration site 1.	0.683
ENSCSEP00000028290	arl13b	ENSCSEP00000028290	ENSCSEP00000008211	Uncharacterized protein.	ADP-ribosylation factor-like 13b.	0.633
ENSCSEP00000028290	smo	ENSCSEP00000028290	ENSCSEP00000014291	Uncharacterized protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.458
ENSCSEP00000028290	ttc21b	ENSCSEP00000028290	ENSCSEP00000013364	Uncharacterized protein.	Tetratricopeptide repeat domain 21B.	0.540
ENSCSEP00000030469	ENSCSEP00000028290	ENSCSEP00000030469	ENSCSEP00000028290	C2-C2_1 domain-containing protein.	Uncharacterized protein.	0.590