56 items (Cynoglossus semilaevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hnf1b	HNF1 homeobox Ba. (623 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1456 aa)
	ptf1a	Pancreas associated transcription factor 1a. (300 aa)
	LOC103379523	Uncharacterized protein. (526 aa)
	LOC103397629	Hcy-binding domain-containing protein. (413 aa)
	LOC103391367	Fibroblast growth factor receptor 2. (661 aa)
	Nav3	Uncharacterized protein. (469 aa)
	IKZF5	IKAROS family zinc finger 5. (489 aa)
	LOC103389096	Histone domain-containing protein. (147 aa)
	rfx3	Regulatory factor X, 3 (influences HLA class II expression). (830 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (271 aa)
	utp25	UTP25 small subunit processor component. (757 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1120 aa)
	MYO1D	Myosin ID; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1004 aa)
	pax6	Paired box 6b. (456 aa)
	rnpc3	RNA-binding region (RNP1, RRM) containing 3. (489 aa)
	LOC103390007	Betaine-homocysteine methyltransferase; Involved in the regulation of homocysteine metabolism. (399 aa)
	LOC103387590	Uncharacterized protein. (271 aa)
	pcsk1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (784 aa)
	srp54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (526 aa)
	LOC103379386	ISL LIM homeobox 2b. (364 aa)
	ENSCSEP00000018671	Spliceosome associated factor 3, U4/U6 recycling protein. (849 aa)
	LOC103381669	Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (488 aa)
	hhex	Homeobox domain-containing protein. (299 aa)
	arx	Aristaless related homeobox a. (470 aa)
	hnf1a	HNF1 homeobox a. (548 aa)
	nkx6-2	NK6 homeobox 2. (287 aa)
	fitm2	Fat storage inducing transmembrane protein 2. (258 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (819 aa)
	isl1	ISL LIM homeobox 1. (349 aa)
	LOC103396957	Uncharacterized protein. (318 aa)
	igf2	Insulin growth factor II. (212 aa)
	wnt5b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (436 aa)
	ENSCSEP00000013420	Paired box 4. (231 aa)
	isl2	ISL LIM homeobox 2a. (402 aa)
	ENSCSEP00000012912	Homeobox domain-containing protein. (427 aa)
	ENSCSEP00000012889	Uncharacterized protein. (192 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (113 aa)
	wfs1	Wolfram syndrome 1b (wolframin). (972 aa)
	LOC103383729	Wolfram syndrome 1a (wolframin). (892 aa)
	LOC103381383	Homeobox domain-containing protein. (256 aa)
	INSM1	INSM transcriptional repressor 1. (336 aa)
	yap1	Yes-associated protein 1. (438 aa)
	neurod1	Neurogenic differentiation factor. (353 aa)
	ENSCSEP00000007572	Regulatory factor X, 6. (839 aa)
	suv39h1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (411 aa)
	cdkal1	CDK5 regulatory subunit associated protein 1-like 1. (564 aa)
	LOC103387042	IKAROS family zinc finger 5. (423 aa)
	LOC103384668	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (437 aa)
	bmp2	Bone morphogenetic protein 2. (422 aa)
	LOC103388203	IL-6 receptor subunit alpha. (587 aa)
	LOC103390439	Notch receptor 1a. (2364 aa)
	LOC103377530	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (403 aa)
	ENSCSEP00000001343	Motor neuron and pancreas homeobox 1. (300 aa)
	LOC103390882	NK2 homeobox 2a. (273 aa)
	LOC103387595	Insulinoma-associated 1b. (443 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSEP00000001343	ENSCSEP00000007572	ENSCSEP00000001343	ENSCSEP00000007572	Motor neuron and pancreas homeobox 1.	Regulatory factor X, 6.	0.572
ENSCSEP00000001343	pcsk1	ENSCSEP00000001343	ENSCSEP00000019665	Motor neuron and pancreas homeobox 1.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.432
ENSCSEP00000001343	ptf1a	ENSCSEP00000001343	ENSCSEP00000033081	Motor neuron and pancreas homeobox 1.	Pancreas associated transcription factor 1a.	0.493
ENSCSEP00000007572	ENSCSEP00000001343	ENSCSEP00000007572	ENSCSEP00000001343	Regulatory factor X, 6.	Motor neuron and pancreas homeobox 1.	0.572
ENSCSEP00000007572	hhex	ENSCSEP00000007572	ENSCSEP00000017576	Regulatory factor X, 6.	Homeobox domain-containing protein.	0.416
ENSCSEP00000007572	ins	ENSCSEP00000007572	ENSCSEP00000010805	Regulatory factor X, 6.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.577
ENSCSEP00000007572	neurod1	ENSCSEP00000007572	ENSCSEP00000008194	Regulatory factor X, 6.	Neurogenic differentiation factor.	0.447
ENSCSEP00000007572	ptf1a	ENSCSEP00000007572	ENSCSEP00000033081	Regulatory factor X, 6.	Pancreas associated transcription factor 1a.	0.438
ENSCSEP00000012889	hnf1b	ENSCSEP00000012889	ENSCSEP00000022376	Uncharacterized protein.	HNF1 homeobox Ba.	0.645
ENSCSEP00000012912	hnf1b	ENSCSEP00000012912	ENSCSEP00000022376	Homeobox domain-containing protein.	HNF1 homeobox Ba.	0.655
ENSCSEP00000013420	ins	ENSCSEP00000013420	ENSCSEP00000010805	Paired box 4.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.464
ENSCSEP00000013420	pdx1	ENSCSEP00000013420	ENSCSEP00000025793	Paired box 4.	Pancreatic and duodenal homeobox 1.	0.470
LOC103377530	LOC103390439	ENSCSEP00000001420	ENSCSEP00000002011	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Notch receptor 1a.	0.500
LOC103377530	smo	ENSCSEP00000001420	ENSCSEP00000014291	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.825
LOC103379386	ptf1a	ENSCSEP00000019230	ENSCSEP00000033081	ISL LIM homeobox 2b.	Pancreas associated transcription factor 1a.	0.405
LOC103379523	ins	ENSCSEP00000032918	ENSCSEP00000010805	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.464
LOC103379523	pdx1	ENSCSEP00000032918	ENSCSEP00000025793	Uncharacterized protein.	Pancreatic and duodenal homeobox 1.	0.470
LOC103381383	ins	ENSCSEP00000008833	ENSCSEP00000010805	Homeobox domain-containing protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.526
LOC103381383	neurod1	ENSCSEP00000008833	ENSCSEP00000008194	Homeobox domain-containing protein.	Neurogenic differentiation factor.	0.489
LOC103381383	nkx6-2	ENSCSEP00000008833	ENSCSEP00000016304	Homeobox domain-containing protein.	NK6 homeobox 2.	0.464