(43 nodes) Negative regulation of TOR signaling network (Cynoglossus semilaevis)

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Predicted Interactions

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Your Input:
	c8h12orf66	Si:ch211-125a15.1. (513 aa)
	sh3bp4	SH3-domain binding protein 4. (958 aa)
	UBR1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1735 aa)
	tsc1	TSC complex subunit 1b. (1273 aa)
	rnf152	Ring finger protein 152. (174 aa)
	Atm	Non-specific serine/threonine protein kinase. (3052 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (2254 aa)
	Szt2	Uncharacterized protein. (191 aa)
	Tbc1d7	TBC1 domain family, member 7. (278 aa)
	bmt2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (386 aa)
	ubr2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1706 aa)
	Prkaa2	Non-specific serine/threonine protein kinase. (551 aa)
	kptn	Kaptin (actin binding protein). (458 aa)
	LOC103397646	MAPK activated protein kinase 5. (471 aa)
	flcn	Folliculin. (554 aa)
	LOC103387999	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (441 aa)
	LOC103393872	Glycogen synthase kinase 3 alpha a. (655 aa)
	nprl3	NPR3-like, GATOR1 complex subunit. (568 aa)
	CASTOR1	Cytosolic arginine sensor for mTORC1 subunit 1. (335 aa)
	depdc5	DEP domain containing 5. (1498 aa)
	nprl2	NPR2 like, GATOR1 complex subunit. (383 aa)
	ENSCSEP00000007176	Uncharacterized protein. (56 aa)
	deptor	DEP domain containing MTOR-interacting protein. (455 aa)
	LOC103389526	SH3-domain binding protein 4a. (952 aa)
	LOC103390849	Si:zfos-80g12.1. (444 aa)
	minar1	Membrane integral NOTCH2 associated receptor 1. (927 aa)
	LOC103386253	UPF0258 domain-containing protein. (800 aa)
	LOC103397967	TSC complex subunit 1. (1108 aa)
	LOC103396963	Protein kinase domain-containing protein. (456 aa)
	LOC103386314	Si:dkeyp-97e7.9. (381 aa)
	TMEM127	Transmembrane protein 127. (220 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate b. (474 aa)
	tsc2	TSC complex subunit 2. (1778 aa)
	akt1s1	AKT1 substrate 1 (proline-rich). (356 aa)
	fnip1	Folliculin interacting protein 1. (1242 aa)
	LOC103397396	Transmembrane protein 127. (204 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (436 aa)
	castor2	Cytosolic arginine sensor for mTORC1 subunit 2. (328 aa)
	LOC103390073	Non-specific serine/threonine protein kinase. (574 aa)
	LOC103394340	Sestrin 2. (415 aa)
	ddit4	DNA-damage-inducible transcript 4. (226 aa)
	sirt1	Sirtuin 1. (647 aa)
	sesn1	Sestrin 1. (547 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	LOC103386314	ENSCSEP00000003106	ENSCSEP00000015390	Non-specific serine/threonine protein kinase.	Si:dkeyp-97e7.9.	0.409
Atm	deptor	ENSCSEP00000003106	ENSCSEP00000008076	Non-specific serine/threonine protein kinase.	DEP domain containing MTOR-interacting protein.	0.409
Atm	sirt1	ENSCSEP00000003106	ENSCSEP00000027127	Non-specific serine/threonine protein kinase.	Sirtuin 1.	0.611
Atm	stk11	ENSCSEP00000003106	ENSCSEP00000022612	Non-specific serine/threonine protein kinase.	Serine/threonine kinase 11; Belongs to the protein kinase superfamily.	0.609
Atm	tsc2	ENSCSEP00000003106	ENSCSEP00000018011	Non-specific serine/threonine protein kinase.	TSC complex subunit 2.	0.456
CASTOR1	ENSCSEP00000007176	ENSCSEP00000032945	ENSCSEP00000007176	Cytosolic arginine sensor for mTORC1 subunit 1.	Uncharacterized protein.	0.635
CASTOR1	SZT2	ENSCSEP00000032945	ENSCSEP00000003155	Cytosolic arginine sensor for mTORC1 subunit 1.	SZT2 subunit of KICSTOR complex.	0.424
CASTOR1	c8h12orf66	ENSCSEP00000032945	ENSCSEP00000006786	Cytosolic arginine sensor for mTORC1 subunit 1.	Si:ch211-125a15.1.	0.635
CASTOR1	castor2	ENSCSEP00000032945	ENSCSEP00000023134	Cytosolic arginine sensor for mTORC1 subunit 1.	Cytosolic arginine sensor for mTORC1 subunit 2.	0.901
CASTOR1	depdc5	ENSCSEP00000032945	ENSCSEP00000032982	Cytosolic arginine sensor for mTORC1 subunit 1.	DEP domain containing 5.	0.599
CASTOR1	kptn	ENSCSEP00000032945	ENSCSEP00000027700	Cytosolic arginine sensor for mTORC1 subunit 1.	Kaptin (actin binding protein).	0.582
CASTOR1	nprl2	ENSCSEP00000032945	ENSCSEP00000033885	Cytosolic arginine sensor for mTORC1 subunit 1.	NPR2 like, GATOR1 complex subunit.	0.514
CASTOR1	nprl3	ENSCSEP00000032945	ENSCSEP00000032872	Cytosolic arginine sensor for mTORC1 subunit 1.	NPR3-like, GATOR1 complex subunit.	0.580
ENSCSEP00000007176	CASTOR1	ENSCSEP00000007176	ENSCSEP00000032945	Uncharacterized protein.	Cytosolic arginine sensor for mTORC1 subunit 1.	0.635
ENSCSEP00000007176	LOC103390849	ENSCSEP00000007176	ENSCSEP00000008816	Uncharacterized protein.	Si:zfos-80g12.1.	0.489
ENSCSEP00000007176	LOC103394340	ENSCSEP00000007176	ENSCSEP00000024988	Uncharacterized protein.	Sestrin 2.	0.564
ENSCSEP00000007176	SZT2	ENSCSEP00000007176	ENSCSEP00000003155	Uncharacterized protein.	SZT2 subunit of KICSTOR complex.	0.989
ENSCSEP00000007176	Tbc1d7	ENSCSEP00000007176	ENSCSEP00000003480	Uncharacterized protein.	TBC1 domain family, member 7.	0.480
ENSCSEP00000007176	bmt2	ENSCSEP00000007176	ENSCSEP00000003525	Uncharacterized protein.	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	0.780
ENSCSEP00000007176	c8h12orf66	ENSCSEP00000007176	ENSCSEP00000006786	Uncharacterized protein.	Si:ch211-125a15.1.	0.993