(33 nodes) Regulation of intracellular steroid hormone receptor signaling pathway network (Cynoglossus semilaevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	LOC103379789	Dynein axonemal assembly factor 4. (401 aa)
	nr0b1	Dax1. (298 aa)
	ENSCSEP00000010137	E1A binding protein p300 b. (2546 aa)
	brca1	Uncharacterized protein. (1217 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1707 aa)
	LOC103399516	ANK_REP_REGION domain-containing protein. (120 aa)
	prmt2	Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (389 aa)
	rnf14	RBR-type E3 ubiquitin transferase. (482 aa)
	ENSCSEP00000021195	RING-type domain-containing protein. (78 aa)
	dab2	DAB adaptor protein 2. (807 aa)
	carm1	Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (558 aa)
	ar	Androgen receptor. (629 aa)
	tcf21	Transcription factor 21. (183 aa)
	LOC103398716	Uncharacterized protein. (547 aa)
	Cnot2	Uncharacterized protein. (75 aa)
	cnot2	CCR4-NOT transcription complex, subunit 2. (484 aa)
	LOC103391230	Uncharacterized protein. (712 aa)
	ncor1	Nuclear receptor corepressor 1. (2354 aa)
	cnot9	CCR4-NOT transcription complex subunit 9. (299 aa)
	ENSCSEP00000025989	Ring finger protein (C3H2C3 type) 6. (593 aa)
	phb	Prohibitin. (271 aa)
	sirt1	Sirtuin 1. (647 aa)
	pagr1	PAXIP1 associated glutamate-rich protein 1. (297 aa)
	LOC103397659	Zinc finger protein 366. (772 aa)
	LOC103396542	RBR-type E3 ubiquitin transferase. (473 aa)
	vps11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (899 aa)
	LOC103383092	NOT2_3_5 domain-containing protein. (564 aa)
	EP300	E1A binding protein p300. (2880 aa)
	DNAAF4	Dynein axonemal assembly factor 4. (411 aa)
	Kank2	Uncharacterized protein. (284 aa)
	ENSCSEP00000032865	ANK_REP_REGION domain-containing protein. (143 aa)
	Cnot1	CCR4-NOT transcription complex, subunit 1. (829 aa)
	ENSCSEP00000033498	CCR4-NOT transcription complex, subunit 1. (1499 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cnot1	Cnot2	ENSCSEP00000033491	ENSCSEP00000024311	CCR4-NOT transcription complex, subunit 1.	Uncharacterized protein.	0.891
Cnot1	ENSCSEP00000033498	ENSCSEP00000033491	ENSCSEP00000033498	CCR4-NOT transcription complex, subunit 1.	CCR4-NOT transcription complex, subunit 1.	0.957
Cnot1	LOC103383092	ENSCSEP00000033491	ENSCSEP00000031449	CCR4-NOT transcription complex, subunit 1.	NOT2_3_5 domain-containing protein.	0.927
Cnot1	cnot2	ENSCSEP00000033491	ENSCSEP00000024337	CCR4-NOT transcription complex, subunit 1.	CCR4-NOT transcription complex, subunit 2.	0.927
Cnot1	cnot9	ENSCSEP00000033491	ENSCSEP00000025367	CCR4-NOT transcription complex, subunit 1.	CCR4-NOT transcription complex subunit 9.	0.979
Cnot2	Cnot1	ENSCSEP00000024311	ENSCSEP00000033491	Uncharacterized protein.	CCR4-NOT transcription complex, subunit 1.	0.891
Cnot2	ENSCSEP00000033498	ENSCSEP00000024311	ENSCSEP00000033498	Uncharacterized protein.	CCR4-NOT transcription complex, subunit 1.	0.891
Cnot2	LOC103383092	ENSCSEP00000024311	ENSCSEP00000031449	Uncharacterized protein.	NOT2_3_5 domain-containing protein.	0.900
Cnot2	cnot9	ENSCSEP00000024311	ENSCSEP00000025367	Uncharacterized protein.	CCR4-NOT transcription complex subunit 9.	0.955
ENSCSEP00000010137	LOC103391230	ENSCSEP00000010137	ENSCSEP00000024626	E1A binding protein p300 b.	Uncharacterized protein.	0.632
ENSCSEP00000010137	ar	ENSCSEP00000010137	ENSCSEP00000022097	E1A binding protein p300 b.	Androgen receptor.	0.632
ENSCSEP00000010137	brca1	ENSCSEP00000010137	ENSCSEP00000011390	E1A binding protein p300 b.	Uncharacterized protein.	0.744
ENSCSEP00000010137	carm1	ENSCSEP00000010137	ENSCSEP00000021614	E1A binding protein p300 b.	Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.900
ENSCSEP00000010137	med1	ENSCSEP00000010137	ENSCSEP00000011890	E1A binding protein p300 b.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.705
ENSCSEP00000010137	ncor1	ENSCSEP00000010137	ENSCSEP00000025126	E1A binding protein p300 b.	Nuclear receptor corepressor 1.	0.698
ENSCSEP00000010137	sirt1	ENSCSEP00000010137	ENSCSEP00000027127	E1A binding protein p300 b.	Sirtuin 1.	0.630
ENSCSEP00000032865	Kank2	ENSCSEP00000032865	ENSCSEP00000032864	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.844
ENSCSEP00000033498	Cnot1	ENSCSEP00000033498	ENSCSEP00000033491	CCR4-NOT transcription complex, subunit 1.	CCR4-NOT transcription complex, subunit 1.	0.957
ENSCSEP00000033498	Cnot2	ENSCSEP00000033498	ENSCSEP00000024311	CCR4-NOT transcription complex, subunit 1.	Uncharacterized protein.	0.891
ENSCSEP00000033498	LOC103383092	ENSCSEP00000033498	ENSCSEP00000031449	CCR4-NOT transcription complex, subunit 1.	NOT2_3_5 domain-containing protein.	0.927