27 items (Cynoglossus semilaevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dhfr	Dihydrofolate reductase. (189 aa)
	mthfd1	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (934 aa)
	ENSCSEP00000000278	Folate gamma-glutamyl hydrolase. (351 aa)
	LOC103378725	GTP cyclohydrolase 1. (256 aa)
	Mtr	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1235 aa)
	ENSCSEP00000004588	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (879 aa)
	pts	6-pyruvoyltetrahydropterin synthase. (148 aa)
	aldh1l2	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (901 aa)
	qdpr	Quinoid dihydropteridine reductase a. (236 aa)
	mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (655 aa)
	shmt1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (466 aa)
	mthfs	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (203 aa)
	LOC103387463	Pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha. (102 aa)
	ftcd	Formimidoyltransferase cyclodeaminase. (540 aa)
	LOC103381538	GTP cyclohydrolase 2. (267 aa)
	Fpgs	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (576 aa)
	LOC103380400	Zgc:153031. (196 aa)
	ENSCSEP00000016629	5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (670 aa)
	shmt2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (501 aa)
	LOC103397081	Uncharacterized protein. (338 aa)
	LOC103386516	Folate gamma-glutamyl hydrolase. (364 aa)
	LOC103394942	Uncharacterized protein. (261 aa)
	ENSCSEP00000027705	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (898 aa)
	LOC103397717	Uncharacterized protein. (274 aa)
	LOC103397649	Folate gamma-glutamyl hydrolase. (434 aa)
	spr	Sepiapterin reductase b. (307 aa)
	LOC103397730	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (411 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSEP00000000278	Fpgs	ENSCSEP00000000278	ENSCSEP00000015391	Folate gamma-glutamyl hydrolase.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.939
ENSCSEP00000000278	LOC103380400	ENSCSEP00000000278	ENSCSEP00000015533	Folate gamma-glutamyl hydrolase.	Zgc:153031.	0.921
ENSCSEP00000000278	LOC103386516	ENSCSEP00000000278	ENSCSEP00000023896	Folate gamma-glutamyl hydrolase.	Folate gamma-glutamyl hydrolase.	0.904
ENSCSEP00000000278	LOC103397649	ENSCSEP00000000278	ENSCSEP00000028293	Folate gamma-glutamyl hydrolase.	Folate gamma-glutamyl hydrolase.	0.905
ENSCSEP00000000278	dhfr	ENSCSEP00000000278	ENSCSEP00000024916	Folate gamma-glutamyl hydrolase.	Dihydrofolate reductase.	0.921
ENSCSEP00000004588	ENSCSEP00000016629	ENSCSEP00000004588	ENSCSEP00000016629	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	5-methyltetrahydrofolate-homocysteine methyltransferase reductase.	0.463
ENSCSEP00000004588	ENSCSEP00000027705	ENSCSEP00000004588	ENSCSEP00000027705	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.543
ENSCSEP00000004588	Fpgs	ENSCSEP00000004588	ENSCSEP00000015391	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.943
ENSCSEP00000004588	LOC103378725	ENSCSEP00000004588	ENSCSEP00000002347	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	GTP cyclohydrolase 1.	0.417
ENSCSEP00000004588	LOC103380400	ENSCSEP00000004588	ENSCSEP00000015533	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Zgc:153031.	0.958
ENSCSEP00000004588	LOC103381538	ENSCSEP00000004588	ENSCSEP00000015016	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	GTP cyclohydrolase 2.	0.417
ENSCSEP00000004588	LOC103397081	ENSCSEP00000004588	ENSCSEP00000017681	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Uncharacterized protein.	0.979
ENSCSEP00000004588	LOC103397730	ENSCSEP00000004588	ENSCSEP00000031458	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.979
ENSCSEP00000004588	Mtr	ENSCSEP00000004588	ENSCSEP00000004127	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.969
ENSCSEP00000004588	aldh1l2	ENSCSEP00000004588	ENSCSEP00000004891	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.543
ENSCSEP00000004588	dhfr	ENSCSEP00000004588	ENSCSEP00000024916	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Dihydrofolate reductase.	0.959
ENSCSEP00000004588	ftcd	ENSCSEP00000004588	ENSCSEP00000014049	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Formimidoyltransferase cyclodeaminase.	0.975
ENSCSEP00000004588	mthfd1	ENSCSEP00000004588	ENSCSEP00000000230	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b.	0.902
ENSCSEP00000004588	mthfr	ENSCSEP00000004588	ENSCSEP00000007478	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.781
ENSCSEP00000004588	mthfs	ENSCSEP00000004588	ENSCSEP00000010517	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.	0.809