(80 nodes) Regulation of neuron differentiation network (Cynoglossus semilaevis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103387688	Dickkopf WNT signaling pathway inhibitor 1a. (253 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1488 aa)
	ENSCSEP00000000205	RWD domain-containing protein. (132 aa)
	LOC103386479	SIX homeobox 7. (261 aa)
	SPAG9	Sperm associated antigen 9. (1346 aa)
	EIF4ENIF1	Eukaryotic translation initiation factor 4E nuclear import factor 1. (860 aa)
	six6	SIX homeobox 6a. (245 aa)
	LOC103399842	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. (889 aa)
	id2	Inhibitor of DNA binding 2a. (143 aa)
	LOC103377624	Fork-head domain-containing protein. (388 aa)
	LOC103383481	Monocyte to macrophage differentiation associated 2. (239 aa)
	LOC103399888	Bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 1. (770 aa)
	LOC103399887	Bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 2. (762 aa)
	ENSCSEP00000005344	Epithelial cell transforming 2. (807 aa)
	six3	SIX homeobox 3a. (293 aa)
	impact	Impact RWD domain protein. (331 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	phox2b	Paired like homeobox 2Bb. (285 aa)
	ascl1	Achaete-scute family bHLH transcription factor 1a. (189 aa)
	gnl3	Guanine nucleotide binding protein-like 3 (nucleolar). (547 aa)
	casz1	Castor zinc finger 1. (2027 aa)
	rest	RE1-silencing transcription factor. (962 aa)
	LOC103376623	Transcription factor 3b. (632 aa)
	LOC103393298	Monocyte to macrophage differentiation associated 2. (245 aa)
	ENSCSEP00000010323	G_PROTEIN_RECEP_F1_2 domain-containing protein. (158 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (248 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1707 aa)
	LOC103381479	Neuronal differentiation 2. (358 aa)
	LOC103392547	NGF domain-containing protein; Belongs to the NGF-beta family. (476 aa)
	LOC103392616	Beta-1,3-N-acetylglucosaminyltransferase. (368 aa)
	ENSCSEP00000033739	Leucine-rich repeat kinase 2. (2316 aa)
	ENSCSEP00000012520	Neurogenin 3. (199 aa)
	LOC103396910	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (184 aa)
	dlx1	Distal-less homeobox 1a. (254 aa)
	dlx2	Distal-less homeobox 2b. (327 aa)
	LOC103381532	SIX homeobox 3b. (313 aa)
	irx3	Iroquois homeobox 3a. (431 aa)
	ENSCSEP00000015353	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (415 aa)
	vwc2	Von Willebrand factor C domain containing 2. (333 aa)
	brinp3	Bone morphogenetic protein/retinoic acid inducible neural-specific 3b. (786 aa)
	lsm1	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (145 aa)
	ret	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1111 aa)
	foxg1	Forkhead box G1a. (425 aa)
	Lrrc45	Leucine rich repeat containing 45. (603 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (911 aa)
	vwc2l	Von Willebrand factor C domain containing 2 like. (228 aa)
	LOC103380476	BHLH domain-containing protein. (495 aa)
	LOC103391098	Neurogenin 1. (198 aa)
	glra1	Glycine receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (470 aa)
	mib1	Mindbomb E3 ubiquitin protein ligase 1. (1041 aa)
	LOC103392953	Sperm associated antigen 9a. (1286 aa)
	nepro	Nucleolus and neural progenitor protein. (470 aa)
	LOC103388899	Inhibitor of DNA binding 4. (144 aa)
	mapk8ip3	Mitogen-activated protein kinase 8 interacting protein 3. (1315 aa)
	cntn2	Contactin 2. (1042 aa)
	gprc5b	G protein-coupled receptor, class C, group 5, member Ba. (398 aa)
	LOC103395943	Transcription factor 3a. (649 aa)
	MOSMO	Modulator of smoothened. (218 aa)
	DISP3	Dispatched RND transporter family member 3. (1313 aa)
	ENSCSEP00000023739	Fork-head domain-containing protein. (318 aa)
	LOC103384296	Glycine receptor, alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (539 aa)
	zc4h2	Zinc finger, C4H2 domain containing. (219 aa)
	TCF4	Transcription factor 4. (778 aa)
	lbx1	Homeobox domain-containing protein. (270 aa)
	NEUROD2	Neurogenic differentiation factor. (354 aa)
	trim32	Tripartite motif containing 32. (682 aa)
	brinp1	Bone morphogenetic protein/retinoic acid inducible neural-specific 1. (757 aa)
	fez1	Fasciculation and elongation protein zeta 1 (zygin I). (408 aa)
	ntf3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (241 aa)
	LOC103391315	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (412 aa)
	ENSCSEP00000028793	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (225 aa)
	ENSCSEP00000028980	Uncharacterized protein. (718 aa)
	ENSCSEP00000029338	G_PROTEIN_RECEP_F1_2 domain-containing protein. (192 aa)
	LOC103378548	Uncharacterized protein. (343 aa)
	tcf12	Transcription factor 12. (716 aa)
	Hes3	Hairy-related 3. (251 aa)
	LOC103384498	Hairy-related 12. (164 aa)
	nkx2-5	NK2 homeobox 5. (329 aa)
	ARHGEF2	Rho/rac guanine nucleotide exchange factor (GEF) 2. (726 aa)
	Mmd	Monocyte to macrophage differentiation-associated. (232 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH2	LOC103399842	ENSCSEP00000017607	ENSCSEP00000003218	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins.	0.901
EIF2AK4	ENSCSEP00000000205	ENSCSEP00000000204	ENSCSEP00000000205	Eukaryotic translation initiation factor 2 alpha kinase 4.	RWD domain-containing protein.	0.839
EIF2AK4	impact	ENSCSEP00000000204	ENSCSEP00000005977	Eukaryotic translation initiation factor 2 alpha kinase 4.	Impact RWD domain protein.	0.411
ENSCSEP00000000205	EIF2AK4	ENSCSEP00000000205	ENSCSEP00000000204	RWD domain-containing protein.	Eukaryotic translation initiation factor 2 alpha kinase 4.	0.839
ENSCSEP00000000205	impact	ENSCSEP00000000205	ENSCSEP00000005977	RWD domain-containing protein.	Impact RWD domain protein.	0.411
ENSCSEP00000012520	LOC103376623	ENSCSEP00000012520	ENSCSEP00000008989	Neurogenin 3.	Transcription factor 3b.	0.403
ENSCSEP00000012520	LOC103380476	ENSCSEP00000012520	ENSCSEP00000019136	Neurogenin 3.	BHLH domain-containing protein.	0.400
ENSCSEP00000012520	LOC103395943	ENSCSEP00000012520	ENSCSEP00000022335	Neurogenin 3.	Transcription factor 3a.	0.408
ENSCSEP00000012520	TCF4	ENSCSEP00000012520	ENSCSEP00000024794	Neurogenin 3.	Transcription factor 4.	0.408
ENSCSEP00000012520	ascl1	ENSCSEP00000012520	ENSCSEP00000007179	Neurogenin 3.	Achaete-scute family bHLH transcription factor 1a.	0.467
ENSCSEP00000012520	tcf12	ENSCSEP00000012520	ENSCSEP00000029797	Neurogenin 3.	Transcription factor 12.	0.408
ENSCSEP00000023739	LOC103377624	ENSCSEP00000023739	ENSCSEP00000003398	Fork-head domain-containing protein.	Fork-head domain-containing protein.	0.907
ENSCSEP00000028793	ret	ENSCSEP00000028793	ENSCSEP00000016872	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.489
LOC103376623	ENSCSEP00000012520	ENSCSEP00000008989	ENSCSEP00000012520	Transcription factor 3b.	Neurogenin 3.	0.403
LOC103376623	LOC103388899	ENSCSEP00000008989	ENSCSEP00000020934	Transcription factor 3b.	Inhibitor of DNA binding 4.	0.592
LOC103376623	LOC103391098	ENSCSEP00000008989	ENSCSEP00000019907	Transcription factor 3b.	Neurogenin 1.	0.403
LOC103376623	ascl1	ENSCSEP00000008989	ENSCSEP00000007179	Transcription factor 3b.	Achaete-scute family bHLH transcription factor 1a.	0.795
LOC103376623	id2	ENSCSEP00000008989	ENSCSEP00000003320	Transcription factor 3b.	Inhibitor of DNA binding 2a.	0.630
LOC103377624	ENSCSEP00000023739	ENSCSEP00000003398	ENSCSEP00000023739	Fork-head domain-containing protein.	Fork-head domain-containing protein.	0.907
LOC103378548	LOC103387688	ENSCSEP00000029591	ENSCSEP00000025593	Uncharacterized protein.	Dickkopf WNT signaling pathway inhibitor 1a.	0.464