(43 nodes) Positive regulation of endocytosis network (Cynoglossus semilaevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pcsk9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (597 aa)
	LOC103380179	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1510 aa)
	scyl2	SCY1 like pseudokinase 2. (915 aa)
	ahi1	Abelson helper integration site 1. (1202 aa)
	pick1	Protein interacting with prkca 1. (418 aa)
	ENSCSEP00000011179	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (240 aa)
	magi2	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1542 aa)
	vtn	Vitronectin a. (591 aa)
	hras-2	Zgc:123278. (192 aa)
	tsg101	Tumor susceptibility 101a. (390 aa)
	LOC103386293	Uncharacterized protein. (191 aa)
	LOC103380360	Protein tyrosine phosphatase non-receptor type 5. (573 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (590 aa)
	appl2	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2. (665 aa)
	ano6	Anoctamin. (921 aa)
	ppt1	Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile). (303 aa)
	ankfy1	Ankyrin repeat and FYVE domain containing 1. (1166 aa)
	ENSCSEP00000018456	SH2 domain-containing protein. (374 aa)
	LOC103394110	Low density lipoprotein receptor adaptor protein 1a. (303 aa)
	tbc1d5	TBC1 domain family, member 5. (884 aa)
	eef2k	Eukaryotic elongation factor 2 kinase. (695 aa)
	dab2	DAB adaptor protein 2. (807 aa)
	cln3	Battenin. (439 aa)
	Clul1	Clusterin; Belongs to the clusterin family. (463 aa)
	LOC103389012	Apolipoprotein Eb. (346 aa)
	fmr1	Fragile X mental retardation 1. (581 aa)
	LOC103382988	Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase. (464 aa)
	ENSCSEP00000026811	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (455 aa)
	LOC103393775	Uncharacterized protein. (193 aa)
	vps28	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (223 aa)
	appl1	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (708 aa)
	LOC103395458	Vitronectin b. (441 aa)
	LOC103385566	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (418 aa)
	CDC42	Cell division cycle 42. (191 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	LOC103387948	Uncharacterized protein. (193 aa)
	cd63	Tetraspanin. (240 aa)
	ENSCSEP00000033739	Leucine-rich repeat kinase 2. (2316 aa)
	LOC103381019	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (251 aa)
	clu	Clusterin; Belongs to the clusterin family. (464 aa)
	ldlrap1	Low density lipoprotein receptor adaptor protein 1b. (312 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (186 aa)
	LOC103381185	Gremlin 1a, DAN family BMP antagonist. (182 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	ankfy1	ENSCSEP00000030390	ENSCSEP00000017606	Cell division cycle 42.	Ankyrin repeat and FYVE domain containing 1.	0.481
Clul1	LOC103389012	ENSCSEP00000021847	ENSCSEP00000023628	Clusterin; Belongs to the clusterin family.	Apolipoprotein Eb.	0.504
Clul1	LOC103395458	ENSCSEP00000021847	ENSCSEP00000029441	Clusterin; Belongs to the clusterin family.	Vitronectin b.	0.455
Clul1	vtn	ENSCSEP00000021847	ENSCSEP00000012153	Clusterin; Belongs to the clusterin family.	Vitronectin a.	0.455
GREM1	LOC103381185	ENSCSEP00000000208	ENSCSEP00000005546	Gremlin 1, DAN family BMP antagonist.	Gremlin 1a, DAN family BMP antagonist.	0.902
LOC103381185	GREM1	ENSCSEP00000005546	ENSCSEP00000000208	Gremlin 1a, DAN family BMP antagonist.	Gremlin 1, DAN family BMP antagonist.	0.902
LOC103385566	LOC103395458	ENSCSEP00000029573	ENSCSEP00000029441	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	Vitronectin b.	0.965
LOC103385566	vtn	ENSCSEP00000029573	ENSCSEP00000012153	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	Vitronectin a.	0.965
LOC103386293	LOC103387948	ENSCSEP00000013018	ENSCSEP00000031199	Uncharacterized protein.	Uncharacterized protein.	0.900
LOC103386293	ankfy1	ENSCSEP00000013018	ENSCSEP00000017606	Uncharacterized protein.	Ankyrin repeat and FYVE domain containing 1.	0.481
LOC103387948	LOC103386293	ENSCSEP00000031199	ENSCSEP00000013018	Uncharacterized protein.	Uncharacterized protein.	0.900
LOC103387948	ankfy1	ENSCSEP00000031199	ENSCSEP00000017606	Uncharacterized protein.	Ankyrin repeat and FYVE domain containing 1.	0.477
LOC103389012	Clul1	ENSCSEP00000023628	ENSCSEP00000021847	Apolipoprotein Eb.	Clusterin; Belongs to the clusterin family.	0.504
LOC103389012	LOC103394110	ENSCSEP00000023628	ENSCSEP00000018551	Apolipoprotein Eb.	Low density lipoprotein receptor adaptor protein 1a.	0.554
LOC103389012	LOC103395458	ENSCSEP00000023628	ENSCSEP00000029441	Apolipoprotein Eb.	Vitronectin b.	0.561
LOC103389012	clu	ENSCSEP00000023628	ENSCSEP00000005661	Apolipoprotein Eb.	Clusterin; Belongs to the clusterin family.	0.446
LOC103389012	ldlrap1	ENSCSEP00000023628	ENSCSEP00000000122	Apolipoprotein Eb.	Low density lipoprotein receptor adaptor protein 1b.	0.628
LOC103389012	vtn	ENSCSEP00000023628	ENSCSEP00000012153	Apolipoprotein Eb.	Vitronectin a.	0.561
LOC103393775	ankfy1	ENSCSEP00000027772	ENSCSEP00000017606	Uncharacterized protein.	Ankyrin repeat and FYVE domain containing 1.	0.477
LOC103394110	LOC103389012	ENSCSEP00000018551	ENSCSEP00000023628	Low density lipoprotein receptor adaptor protein 1a.	Apolipoprotein Eb.	0.554