(15 nodes) Positive regulation of isotype switching network (Cynoglossus semilaevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (749 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	LOC103392691	SET domain-containing protein. (2060 aa)
	kmt5b	Lysine methyltransferase 5B. (887 aa)
	LOC103377845	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	exosc3	Exosome component 3. (244 aa)
	hmces	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (336 aa)
	Rif1	Replication timing regulatory factor 1. (2288 aa)
	LOC103398007	Uncharacterized protein. (287 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1101 aa)
	ENSCSEP00000020096	Uncharacterized protein. (707 aa)
	Whsc1	Nuclear receptor binding SET domain protein 2. (931 aa)
	tbx21	T-box transcription factor 21. (575 aa)
	LOC112487665	Uncharacterized protein. (336 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1258 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSEP00000020096	msh2	ENSCSEP00000020096	ENSCSEP00000015081	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.472
LOC103392691	tp53bp1	ENSCSEP00000013530	ENSCSEP00000015332	SET domain-containing protein.	Tumor protein p53 binding protein, 1.	0.446
LOC103398007	Rif1	ENSCSEP00000015319	ENSCSEP00000006131	Uncharacterized protein.	Replication timing regulatory factor 1.	0.410
LOC112487665	ptprc	ENSCSEP00000023488	ENSCSEP00000025863	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.507
Rif1	LOC103398007	ENSCSEP00000006131	ENSCSEP00000015319	Replication timing regulatory factor 1.	Uncharacterized protein.	0.410
Rif1	Whsc1	ENSCSEP00000006131	ENSCSEP00000021264	Replication timing regulatory factor 1.	Nuclear receptor binding SET domain protein 2.	0.586
Rif1	tp53bp1	ENSCSEP00000006131	ENSCSEP00000015332	Replication timing regulatory factor 1.	Tumor protein p53 binding protein, 1.	0.823
Whsc1	Rif1	ENSCSEP00000021264	ENSCSEP00000006131	Nuclear receptor binding SET domain protein 2.	Replication timing regulatory factor 1.	0.586
Whsc1	tp53bp1	ENSCSEP00000021264	ENSCSEP00000015332	Nuclear receptor binding SET domain protein 2.	Tumor protein p53 binding protein, 1.	0.719
kmt5b	tp53bp1	ENSCSEP00000013310	ENSCSEP00000015332	Lysine methyltransferase 5B.	Tumor protein p53 binding protein, 1.	0.446
mlh1	msh2	ENSCSEP00000027286	ENSCSEP00000015081	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.996
msh2	ENSCSEP00000020096	ENSCSEP00000015081	ENSCSEP00000020096	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Uncharacterized protein.	0.472
msh2	mlh1	ENSCSEP00000015081	ENSCSEP00000027286	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.996
ptprc	LOC112487665	ENSCSEP00000025863	ENSCSEP00000023488	Protein tyrosine phosphatase receptor type C.	Uncharacterized protein.	0.507
ptprc	tbx21	ENSCSEP00000025863	ENSCSEP00000023162	Protein tyrosine phosphatase receptor type C.	T-box transcription factor 21.	0.411
tbx21	ptprc	ENSCSEP00000023162	ENSCSEP00000025863	T-box transcription factor 21.	Protein tyrosine phosphatase receptor type C.	0.411
tp53bp1	LOC103392691	ENSCSEP00000015332	ENSCSEP00000013530	Tumor protein p53 binding protein, 1.	SET domain-containing protein.	0.446
tp53bp1	Rif1	ENSCSEP00000015332	ENSCSEP00000006131	Tumor protein p53 binding protein, 1.	Replication timing regulatory factor 1.	0.823
tp53bp1	Whsc1	ENSCSEP00000015332	ENSCSEP00000021264	Tumor protein p53 binding protein, 1.	Nuclear receptor binding SET domain protein 2.	0.719
tp53bp1	kmt5b	ENSCSEP00000015332	ENSCSEP00000013310	Tumor protein p53 binding protein, 1.	Lysine methyltransferase 5B.	0.446