(109 nodes) Protein stabilization network (Cynoglossus semilaevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103382583	Zgc:154055. (581 aa)
	LOC103380988	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2. (728 aa)
	LOC103378644	Lysosomal associated membrane protein 1. (370 aa)
	pex6	Uncharacterized protein. (1008 aa)
	cdc37l1	Cell division cycle 37-like 1. (338 aa)
	marchf7	Membrane-associated ring finger (C3HC4) 7. (775 aa)
	Tspan1	Tetraspanin 1; Belongs to the tetraspanin (TM4SF) family. (248 aa)
	pim1	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (330 aa)
	LOC103389259	Crystallin, alpha A; Belongs to the small heat shock protein (HSP20) family. (175 aa)
	tsc1	TSC complex subunit 1b. (1273 aa)
	ENSCSEP00000002358	AP2 associated kinase 1b. (386 aa)
	LOC103380989	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (724 aa)
	ppib	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
	ENSCSEP00000003207	Lysosomal-associated membrane protein 2. (452 aa)
	efna1	Ephrin-A1b; Belongs to the ephrin family. (240 aa)
	a1cf	Apobec1 complementation factor. (614 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (165 aa)
	nlk	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (551 aa)
	clu	Clusterin; Belongs to the clusterin family. (464 aa)
	znf207	Zinc finger protein 207, b. (411 aa)
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (447 aa)
	plpp3	Phospholipid phosphatase 3. (313 aa)
	TMEM19	Transmembrane protein 19. (302 aa)
	otud3	OTU deubiquitinase 3. (358 aa)
	LOC103383729	Wolfram syndrome 1a (wolframin). (892 aa)
	LOC103390024	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (287 aa)
	ENSCSEP00000010137	E1A binding protein p300 b. (2546 aa)
	LOC103383749	Activating transcription factor 7 interacting protein. (923 aa)
	wfs1	Wolfram syndrome 1b (wolframin). (972 aa)
	msx1	Muscle segment homeobox 1a. (284 aa)
	gtpbp4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (604 aa)
	LOC103394524	Ephrin-A1a; Belongs to the ephrin family. (226 aa)
	sav1	Salvador family WW domain containing protein 1. (412 aa)
	ENSCSEP00000012218	Uncharacterized protein. (94 aa)
	ENSCSEP00000012550	Uncharacterized protein. (56 aa)
	chek2	Checkpoint kinase 2. (550 aa)
	LOC103396927	BCL2 associated athanogene 4. (357 aa)
	ENSCSEP00000013023	Uncharacterized protein. (154 aa)
	mfsd1	Major facilitator superfamily domain containing 1. (524 aa)
	LOC103397967	TSC complex subunit 1. (1108 aa)
	chp1	Calcineurin-like EF-hand protein 1. (223 aa)
	LOC103378112	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (314 aa)
	LOC103397987	Uncharacterized protein. (505 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (819 aa)
	hypk	Huntingtin interacting protein K. (149 aa)
	grn	Granulin b. (864 aa)
	cog3	Component of oligomeric golgi complex 3. (846 aa)
	LOC103390961	Uncharacterized protein. (245 aa)
	LOC107989939	Apolipoprotein A-IV a. (267 aa)
	LOC103393459	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (475 aa)
	bag2	BCL2 associated athanogene 2. (214 aa)
	ENSCSEP00000016664	Chaperonin containing TCP1, subunit 5 (epsilon). (486 aa)
	Bag3	WW domain-containing protein. (189 aa)
	Morc3	Uncharacterized protein. (168 aa)
	ENSCSEP00000017022	Uncharacterized protein. (117 aa)
	ENSCSEP00000017038	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (563 aa)
	ENSCSEP00000017247	Transmembrane protein 88 a. (225 aa)
	telo2	TEL2, telomere maintenance 2, homolog (S. cerevisiae). (832 aa)
	LOC103388859	BCL2 associated athanogene 6. (945 aa)
	LOC103394140	Uncharacterized protein. (296 aa)
	LOC103393611	Tetraspanin. (247 aa)
	apopt1	Cytochrome c oxidase assembly factor 8. (190 aa)
	bag5	BCL2 associated athanogene 5. (506 aa)
	trim44	Tripartite motif containing 44. (369 aa)
	usp13	Ubiquitin carboxyl-terminal hydrolase. (815 aa)
	ENSCSEP00000021342	Protein kinase domain-containing protein. (782 aa)
	mtmr9	Myotubularin related protein 9. (549 aa)
	Clul1	Clusterin; Belongs to the clusterin family. (463 aa)
	ENSCSEP00000022318	Uncharacterized protein. (615 aa)
	NAA15	N(alpha)-acetyltransferase 15, NatA auxiliary subunit. (864 aa)
	hip1r	Huntingtin interacting protein 1 related b. (1067 aa)
	LOC103378271	Uncharacterized protein. (256 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (454 aa)
	LOC103398247	AP2 associated kinase 1a. (1104 aa)
	LOC103389010	Uncharacterized protein. (255 aa)
	LOC103389009	Uncharacterized protein. (220 aa)
	ENSCSEP00000024035	DNL-type zinc finger. (157 aa)
	ENSCSEP00000024194	ALMS_motif domain-containing protein. (254 aa)
	LOC103390127	Tescalcin b. (223 aa)
	phb	Prohibitin. (271 aa)
	ENSCSEP00000026231	I/LWEQ domain-containing protein. (311 aa)
	ENSCSEP00000026241	Uncharacterized protein. (94 aa)
	camlg	Calcium modulating ligand. (284 aa)
	pink1	PTEN induced kinase 1. (572 aa)
	mul1	Mitochondrial E3 ubiquitin protein ligase 1b. (357 aa)
	atp1b3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
	ENSCSEP00000027612	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (195 aa)
	LOC103395423	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (294 aa)
	glmp	Glycosylated lysosomal membrane protein. (324 aa)
	cct3	T-complex protein 1 subunit gamma. (499 aa)
	rab21	RAB21, member RAS oncogene family. (218 aa)
	LOC103396194	acidPPc domain-containing protein. (311 aa)
	cct2	Chaperonin containing TCP1, subunit 2 (beta). (530 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1117 aa)
	SUGT1	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (274 aa)
	atf7ip2	BED-type domain-containing protein. (468 aa)
	LOC103393843	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (444 aa)
	ENSCSEP00000030084	Huntingtin interacting protein 1. (1006 aa)
	cog7	Component of oligomeric golgi complex 7. (769 aa)
	LOC103387977	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (436 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (294 aa)
	EP300	E1A binding protein p300. (2880 aa)
	LOC103395620	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (249 aa)
	LOC103380891	Heat shock protein 90, alpha (cytosolic), class B member 1. (733 aa)
	ENSCSEP00000032611	Uncharacterized protein. (225 aa)
	CDC37	Cell division cycle 37 homolog (S. cerevisiae). (376 aa)
	LOC103397843	Tescalcin a. (220 aa)
	pex19	Peroxisomal biogenesis factor 19. (294 aa)
	park7	Parkinson protein 7. (221 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bag3	LOC103380891	ENSCSEP00000016669	ENSCSEP00000032336	WW domain-containing protein.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.411
Bag3	LOC103380988	ENSCSEP00000016669	ENSCSEP00000000713	WW domain-containing protein.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.411
Bag3	LOC103380989	ENSCSEP00000016669	ENSCSEP00000002570	WW domain-containing protein.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.411
Bag3	LOC103389259	ENSCSEP00000016669	ENSCSEP00000001728	WW domain-containing protein.	Crystallin, alpha A; Belongs to the small heat shock protein (HSP20) family.	0.692
Bag3	LOC103396927	ENSCSEP00000016669	ENSCSEP00000012878	WW domain-containing protein.	BCL2 associated athanogene 4.	0.746
Bag3	LOC103397967	ENSCSEP00000016669	ENSCSEP00000013293	WW domain-containing protein.	TSC complex subunit 1.	0.411
Bag3	bag2	ENSCSEP00000016669	ENSCSEP00000016422	WW domain-containing protein.	BCL2 associated athanogene 2.	0.911
Bag3	bag5	ENSCSEP00000016669	ENSCSEP00000020588	WW domain-containing protein.	BCL2 associated athanogene 5.	0.661
Bag3	prkn	ENSCSEP00000016669	ENSCSEP00000006207	WW domain-containing protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.545
Bag3	sav1	ENSCSEP00000016669	ENSCSEP00000011857	WW domain-containing protein.	Salvador family WW domain containing protein 1.	0.499
Bag3	tsc1	ENSCSEP00000016669	ENSCSEP00000001914	WW domain-containing protein.	TSC complex subunit 1b.	0.411
CDC37	LOC103380891	ENSCSEP00000032852	ENSCSEP00000032336	Cell division cycle 37 homolog (S. cerevisiae).	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.878
CDC37	LOC103380988	ENSCSEP00000032852	ENSCSEP00000000713	Cell division cycle 37 homolog (S. cerevisiae).	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.885
CDC37	LOC103380989	ENSCSEP00000032852	ENSCSEP00000002570	Cell division cycle 37 homolog (S. cerevisiae).	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1.	0.885
CDC37	LOC103397967	ENSCSEP00000032852	ENSCSEP00000013293	Cell division cycle 37 homolog (S. cerevisiae).	TSC complex subunit 1.	0.745
CDC37	SUGT1	ENSCSEP00000032852	ENSCSEP00000029382	Cell division cycle 37 homolog (S. cerevisiae).	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.402
CDC37	pink1	ENSCSEP00000032852	ENSCSEP00000026950	Cell division cycle 37 homolog (S. cerevisiae).	PTEN induced kinase 1.	0.648
CDC37	tsc1	ENSCSEP00000032852	ENSCSEP00000001914	Cell division cycle 37 homolog (S. cerevisiae).	TSC complex subunit 1b.	0.745
Clul1	LOC103389009	ENSCSEP00000021847	ENSCSEP00000023647	Clusterin; Belongs to the clusterin family.	Uncharacterized protein.	0.427
ENSCSEP00000002358	ENSCSEP00000026231	ENSCSEP00000002358	ENSCSEP00000026231	AP2 associated kinase 1b.	I/LWEQ domain-containing protein.	0.484