(32 nodes) Positive regulation of B cell activation network (Cynoglossus semilaevis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	Rif1	Replication timing regulatory factor 1. (2288 aa)
	AKIRIN2	Akirin 2. (184 aa)
	il10	Interleukin 10. (210 aa)
	hmces	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (336 aa)
	exosc3	Exosome component 3. (244 aa)
	LOC103377845	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	ENSCSEP00000012062	Uncharacterized protein. (216 aa)
	kmt5b	Lysine methyltransferase 5B. (887 aa)
	LOC103392691	SET domain-containing protein. (2060 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	LOC103398007	Uncharacterized protein. (287 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1101 aa)
	LOC103381659	Signal transducer and activator of transcription. (787 aa)
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (250 aa)
	ENSCSEP00000020096	Uncharacterized protein. (707 aa)
	Whsc1	Nuclear receptor binding SET domain protein 2. (931 aa)
	nfatc2	Nuclear factor of activated T cells 2a. (949 aa)
	tbx21	T-box transcription factor 21. (575 aa)
	LOC112487665	Uncharacterized protein. (336 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1258 aa)
	bad	BCL2 associated agonist of cell death b. (178 aa)
	LOC103393172	Signal transducer and activator of transcription. (786 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (749 aa)
	ENSCSEP00000027561	MORN repeat containing 5. (113 aa)
	LOC103377367	Uncharacterized protein. (268 aa)
	ENSCSEP00000030326	Uncharacterized protein. (285 aa)
	LOC103397862	X-box binding protein 1. (260 aa)
	sash3	SAM and SH3 domain containing 3. (407 aa)
	LOC103378028	Akirin 2. (180 aa)
	LOC103384626	Signal transducer and activator of transcription. (761 aa)
	Ppp2r3c	Protein phosphatase 2, regulatory subunit B'', gamma. (452 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1062 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSEP00000020096	msh2	ENSCSEP00000020096	ENSCSEP00000015081	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.472
LOC103377845	il10	ENSCSEP00000008684	ENSCSEP00000006954	Transforming growth factor beta; Belongs to the TGF-beta family.	Interleukin 10.	0.603
LOC103381659	LOC103393172	ENSCSEP00000017209	ENSCSEP00000026747	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.900
LOC103384626	il10	ENSCSEP00000003199	ENSCSEP00000006954	Signal transducer and activator of transcription.	Interleukin 10.	0.577
LOC103384626	tbx21	ENSCSEP00000003199	ENSCSEP00000023162	Signal transducer and activator of transcription.	T-box transcription factor 21.	0.407
LOC103392691	tp53bp1	ENSCSEP00000013530	ENSCSEP00000015332	SET domain-containing protein.	Tumor protein p53 binding protein, 1.	0.446
LOC103393172	LOC103381659	ENSCSEP00000026747	ENSCSEP00000017209	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.900
LOC103398007	Rif1	ENSCSEP00000015319	ENSCSEP00000006131	Uncharacterized protein.	Replication timing regulatory factor 1.	0.410
LOC112487665	il10	ENSCSEP00000023488	ENSCSEP00000006954	Uncharacterized protein.	Interleukin 10.	0.573
LOC112487665	ptprc	ENSCSEP00000023488	ENSCSEP00000025863	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.507
LOC112487665	tnfsf13b	ENSCSEP00000023488	ENSCSEP00000017549	Uncharacterized protein.	TNF superfamily member 13b; Belongs to the tumor necrosis factor family.	0.724
Rif1	LOC103398007	ENSCSEP00000006131	ENSCSEP00000015319	Replication timing regulatory factor 1.	Uncharacterized protein.	0.410
Rif1	Whsc1	ENSCSEP00000006131	ENSCSEP00000021264	Replication timing regulatory factor 1.	Nuclear receptor binding SET domain protein 2.	0.586
Rif1	tp53bp1	ENSCSEP00000006131	ENSCSEP00000015332	Replication timing regulatory factor 1.	Tumor protein p53 binding protein, 1.	0.823
Whsc1	Rif1	ENSCSEP00000021264	ENSCSEP00000006131	Nuclear receptor binding SET domain protein 2.	Replication timing regulatory factor 1.	0.586
Whsc1	tp53bp1	ENSCSEP00000021264	ENSCSEP00000015332	Nuclear receptor binding SET domain protein 2.	Tumor protein p53 binding protein, 1.	0.719
il10	LOC103377845	ENSCSEP00000006954	ENSCSEP00000008684	Interleukin 10.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.603
il10	LOC103384626	ENSCSEP00000006954	ENSCSEP00000003199	Interleukin 10.	Signal transducer and activator of transcription.	0.577
il10	LOC112487665	ENSCSEP00000006954	ENSCSEP00000023488	Interleukin 10.	Uncharacterized protein.	0.573
il10	ptprc	ENSCSEP00000006954	ENSCSEP00000025863	Interleukin 10.	Protein tyrosine phosphatase receptor type C.	0.504