(42 nodes) Bone morphogenesis network (Cynoglossus semilaevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	anxa6	Annexin. (519 aa)
	kat2b	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (791 aa)
	kat2a	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (799 aa)
	ift80	Intraflagellar transport 80 homolog (Chlamydomonas). (777 aa)
	dhrs3	Dehydrogenase/reductase (SDR family) member 3b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
	Frem1	Fras1 related extracellular matrix 1a. (2150 aa)
	LOC103386699	Uncharacterized protein. (185 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (578 aa)
	ENSCSEP00000029566	Checkpoint suppressor 1. (475 aa)
	LOC103385603	RAP1A, member of RAS oncogene family a. (185 aa)
	atg9a	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (858 aa)
	LOC103384668	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (437 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (467 aa)
	serpinh1	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b; Belongs to the serpin family. (405 aa)
	tsku	Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis). (347 aa)
	wnt5b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (436 aa)
	ext2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
	glg1	Golgi glycoprotein 1a. (1145 aa)
	LOC103399182	Fras1 related extracellular matrix 1b. (1751 aa)
	tmem119	Uncharacterized protein. (245 aa)
	gja1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (387 aa)
	msx1	Muscle segment homeobox 1a. (284 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
	ENSCSEP00000010761	Uncharacterized protein. (135 aa)
	MEF2D	Myocyte enhancer factor 2D. (598 aa)
	LOC103390897	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (211 aa)
	pex7	Peroxisomal biogenesis factor 7. (326 aa)
	LOC103388995	Cytochrome P450, family 26, subfamily b, polypeptide 1; Belongs to the cytochrome P450 family. (512 aa)
	LOC103390704	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1059 aa)
	LOC103382506	Uncharacterized protein. (184 aa)
	nab2	NGFI-A binding protein 2 (EGR1 binding protein 2). (495 aa)
	Trip11	Thyroid hormone receptor interactor 11. (1981 aa)
	LOC103388711	Myocyte enhancer factor 2d. (600 aa)
	LOC103388716	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (586 aa)
	rab23	RAB23, member RAS oncogene family. (204 aa)
	ENSCSEP00000017142	Golgi glycoprotein 1b. (1149 aa)
	LOC103396326	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (810 aa)
	sp5	Sp5 transcription factor a. (387 aa)
	LOC103394797	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a; Belongs to the serpin family. (410 aa)
	Edar	Ectodysplasin A receptor. (503 aa)
	LOC103397181	Uncharacterized protein. (283 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSEP00000017142	glg1	ENSCSEP00000017142	ENSCSEP00000002687	Golgi glycoprotein 1b.	Golgi glycoprotein 1a.	0.901
LOC103382506	LOC103385603	ENSCSEP00000006488	ENSCSEP00000033583	Uncharacterized protein.	RAP1A, member of RAS oncogene family a.	0.900
LOC103382506	LOC103386699	ENSCSEP00000006488	ENSCSEP00000029508	Uncharacterized protein.	Uncharacterized protein.	0.900
LOC103384668	wnt5b	ENSCSEP00000004111	ENSCSEP00000013551	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.901
LOC103385603	LOC103382506	ENSCSEP00000033583	ENSCSEP00000006488	RAP1A, member of RAS oncogene family a.	Uncharacterized protein.	0.900
LOC103385603	LOC103386699	ENSCSEP00000033583	ENSCSEP00000029508	RAP1A, member of RAS oncogene family a.	Uncharacterized protein.	0.900
LOC103386699	LOC103382506	ENSCSEP00000029508	ENSCSEP00000006488	Uncharacterized protein.	Uncharacterized protein.	0.900
LOC103386699	LOC103385603	ENSCSEP00000029508	ENSCSEP00000033583	Uncharacterized protein.	RAP1A, member of RAS oncogene family a.	0.900
LOC103388716	TGFBR2	ENSCSEP00000015884	ENSCSEP00000022973	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.901
LOC103388995	dhrs3	ENSCSEP00000007721	ENSCSEP00000028113	Cytochrome P450, family 26, subfamily b, polypeptide 1; Belongs to the cytochrome P450 family.	Dehydrogenase/reductase (SDR family) member 3b; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.653
LOC103390704	fgf4	ENSCSEP00000007011	ENSCSEP00000010997	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.500
LOC103390897	fgf4	ENSCSEP00000009982	ENSCSEP00000010997	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.500
LOC103396326	atg9a	ENSCSEP00000017409	ENSCSEP00000004531	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.902
TGFBR2	LOC103388716	ENSCSEP00000022973	ENSCSEP00000015884	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.901
atg9a	LOC103396326	ENSCSEP00000004531	ENSCSEP00000017409	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.902
dhrs3	LOC103388995	ENSCSEP00000028113	ENSCSEP00000007721	Dehydrogenase/reductase (SDR family) member 3b; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Cytochrome P450, family 26, subfamily b, polypeptide 1; Belongs to the cytochrome P450 family.	0.653
fgf4	LOC103390704	ENSCSEP00000010997	ENSCSEP00000007011	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.500
fgf4	LOC103390897	ENSCSEP00000010997	ENSCSEP00000009982	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.500
glg1	ENSCSEP00000017142	ENSCSEP00000002687	ENSCSEP00000017142	Golgi glycoprotein 1a.	Golgi glycoprotein 1b.	0.901
kat2a	kat2b	ENSCSEP00000026611	ENSCSEP00000026584	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.946