(57 nodes) Positive regulation of small molecule metabolic process network (Cynoglossus semilaevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103390073	Non-specific serine/threonine protein kinase. (574 aa)
	ENSCSEP00000022907	ATP-binding cassette, sub-family G (WHITE), member 4a. (615 aa)
	LOC103396893-3	General transcription factor II-I repeat domain-containing protein 2-like. (477 aa)
	scap	SREBF chaperone. (1275 aa)
	LOC103384911	Nuclear receptor subfamily 1, group H, member 5. (471 aa)
	ABCG4	ATP binding cassette subfamily G member 4. (681 aa)
	LOC103384839	Uncharacterized protein. (187 aa)
	Prkaa2	Non-specific serine/threonine protein kinase. (551 aa)
	LOC103387592	Si:dkey-6n21.13; Belongs to the G-protein coupled receptor 1 family. (386 aa)
	MTLN	Mitoregulin. (56 aa)
	LOC103385872	Si:ch211-103a14.5. (187 aa)
	rusc1	Uncharacterized protein. (1843 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (507 aa)
	dab2	DAB adaptor protein 2. (807 aa)
	LOC103386468	Uncharacterized protein. (108 aa)
	LOC103386467	Uncharacterized protein. (109 aa)
	ddb1	Damage-specific DNA binding protein 1. (1137 aa)
	abcd2	ATP-binding cassette, sub-family D (ALD), member 2. (738 aa)
	prxl2c	Peroxiredoxin like 2C. (225 aa)
	LOC103396893-4	General transcription factor II-I repeat domain-containing protein 2-like. (477 aa)
	sirt1	Sirtuin 1. (647 aa)
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (607 aa)
	LOC103394946	ABC transporter domain-containing protein. (626 aa)
	podn	Podocan. (600 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (462 aa)
	ENSCSEP00000018935	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	LOC103395214	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (149 aa)
	ppara	Peroxisome proliferator-activated receptor alpha a. (478 aa)
	LOC103394701	Nuclear receptor subfamily 1, group D, member 2b. (581 aa)
	LOC103396893-2	Uncharacterized protein. (477 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (468 aa)
	LOC107990188	DUF4371 domain-containing protein. (546 aa)
	igf2	Insulin growth factor II. (212 aa)
	LOC103396898	Interleukin-1. (246 aa)
	LOC103396893	Uncharacterized protein. (514 aa)
	ENSCSEP00000011030	Uncharacterized protein. (232 aa)
	guca1b	Guanylate cyclase activator 1B. (197 aa)
	LOC103395643	Guanylate cyclase activator 1d. (185 aa)
	LOC103382616	ATP-binding cassette, sub-family G (WHITE), member 1. (670 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (468 aa)
	bend3	BEN domain containing 3. (823 aa)
	LOC107990216	DUF4371 domain-containing protein. (606 aa)
	srebf1	Sterol regulatory element binding transcription factor 1. (1172 aa)
	LOC103391194	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (156 aa)
	LOC103389012	Apolipoprotein Eb. (346 aa)
	ncs1	Neuronal calcium sensor 1a. (191 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (579 aa)
	LOC103382714	Guanylate cyclase activator 1A. (206 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (1262 aa)
	Pparg	NR LBD domain-containing protein. (802 aa)
	mlycd	Malonyl-CoA decarboxylase. (505 aa)
	lpgat1	Lysophosphatidylglycerol acyltransferase 1. (372 aa)
	LOC103397875	Interleukin-1; Belongs to the IL-1 family. (246 aa)
	zbtb20	Zinc finger and BTB domain containing 20. (678 aa)
	pid1	Phosphotyrosine interaction domain containing 1. (225 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (368 aa)
	LOC103395654	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (370 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG4	LOC103394946	ENSCSEP00000007360	ENSCSEP00000026514	ATP binding cassette subfamily G member 4.	ABC transporter domain-containing protein.	0.901
ENSCSEP00000011030	LOC103382616	ENSCSEP00000011030	ENSCSEP00000009414	Uncharacterized protein.	ATP-binding cassette, sub-family G (WHITE), member 1.	0.501
ENSCSEP00000011030	Pparg	ENSCSEP00000011030	ENSCSEP00000033731	Uncharacterized protein.	NR LBD domain-containing protein.	0.442
ENSCSEP00000011030	SREBF2	ENSCSEP00000011030	ENSCSEP00000010998	Uncharacterized protein.	Sterol regulatory element binding transcription factor 2.	0.913
ENSCSEP00000011030	nr1h3	ENSCSEP00000011030	ENSCSEP00000019485	Uncharacterized protein.	Nuclear receptor subfamily 1, group H, member 3.	0.458
ENSCSEP00000011030	scap	ENSCSEP00000011030	ENSCSEP00000021876	Uncharacterized protein.	SREBF chaperone.	0.948
ENSCSEP00000011030	sirt1	ENSCSEP00000011030	ENSCSEP00000027127	Uncharacterized protein.	Sirtuin 1.	0.437
ENSCSEP00000011030	srebf1	ENSCSEP00000011030	ENSCSEP00000024159	Uncharacterized protein.	Sterol regulatory element binding transcription factor 1.	0.478
LOC103382616	ENSCSEP00000011030	ENSCSEP00000009414	ENSCSEP00000011030	ATP-binding cassette, sub-family G (WHITE), member 1.	Uncharacterized protein.	0.501
LOC103382616	nr1h3	ENSCSEP00000009414	ENSCSEP00000019485	ATP-binding cassette, sub-family G (WHITE), member 1.	Nuclear receptor subfamily 1, group H, member 3.	0.584
LOC103382714	LOC103395643	ENSCSEP00000010980	ENSCSEP00000009864	Guanylate cyclase activator 1A.	Guanylate cyclase activator 1d.	0.507
LOC103382714	guca1b	ENSCSEP00000010980	ENSCSEP00000028819	Guanylate cyclase activator 1A.	Guanylate cyclase activator 1B.	0.695
LOC103384911	ppargc1a	ENSCSEP00000007684	ENSCSEP00000010745	Nuclear receptor subfamily 1, group H, member 5.	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.	0.853
LOC103385872	LOC103395643	ENSCSEP00000003719	ENSCSEP00000009864	Si:ch211-103a14.5.	Guanylate cyclase activator 1d.	0.504
LOC103385872	guca1b	ENSCSEP00000003719	ENSCSEP00000028819	Si:ch211-103a14.5.	Guanylate cyclase activator 1B.	0.695
LOC103389012	nr1h3	ENSCSEP00000023628	ENSCSEP00000019485	Apolipoprotein Eb.	Nuclear receptor subfamily 1, group H, member 3.	0.410
LOC103390073	Prkaa2	ENSCSEP00000023346	ENSCSEP00000006716	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.917
LOC103390073	sirt1	ENSCSEP00000023346	ENSCSEP00000027127	Non-specific serine/threonine protein kinase.	Sirtuin 1.	0.506
LOC103394701	ppargc1a	ENSCSEP00000016087	ENSCSEP00000010745	Nuclear receptor subfamily 1, group D, member 2b.	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.	0.458
LOC103394946	ABCG4	ENSCSEP00000026514	ENSCSEP00000007360	ABC transporter domain-containing protein.	ATP binding cassette subfamily G member 4.	0.901