(109 nodes) Regulation of ERK1 and ERK2 cascade network (Cynoglossus semilaevis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSCSEP00000002689	Uncharacterized protein. (334 aa)
	LOC103379929	SCY domain-containing protein. (99 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (198 aa)
	errfi1	ERBB receptor feedback inhibitor 1a. (423 aa)
	ENSCSEP00000033581	Protein tyrosine phosphatase non-receptor type 1. (326 aa)
	LOC103383219	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (200 aa)
	LOC103383236	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (522 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (487 aa)
	LOC103397875	Interleukin-1; Belongs to the IL-1 family. (246 aa)
	mfhas1	Malignant fibrous histiocytoma amplified sequence 1. (1029 aa)
	ptpn6	Protein tyrosine phosphatase non-receptor type 6. (571 aa)
	LOC103380805	Si:ch211-153j24.3. (365 aa)
	ENSCSEP00000030876	Uncharacterized protein. (436 aa)
	ENSCSEP00000030215	Inhibitor_Mig-6 domain-containing protein. (298 aa)
	Fgf21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
	ccn2	Cellular communication network factor 2a. (347 aa)
	LOC103385749	SCY domain-containing protein. (91 aa)
	LOC103392484	Fibronectin 1a. (2508 aa)
	LOC103380740	C-C motif chemokine. (105 aa)
	nox4	FAD-binding FR-type domain-containing protein. (554 aa)
	ccn1	Cellular communication network factor 1. (376 aa)
	flcn	Folliculin. (554 aa)
	vrk3	VRK serine/threonine kinase 3. (534 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (368 aa)
	LOC103389156	JunE proto-oncogene, AP-1 transcription factor subunit. (335 aa)
	prxl2c	Peroxiredoxin like 2C. (225 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (578 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	ENSCSEP00000026360	Uncharacterized protein. (255 aa)
	SMAD4	Mothers against decapentaplegic homolog. (503 aa)
	phb	Prohibitin. (271 aa)
	abl1	Tyrosine-protein kinase. (1113 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1258 aa)
	c4h3orf33	C18h3orf33 homolog (H. sapiens). (263 aa)
	cck-2	CC chemokine. (111 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (214 aa)
	LOC103394890	Si:dkey-175m17.7. (878 aa)
	LOC103394304	Mothers against decapentaplegic homolog. (573 aa)
	LOC103394276	Tyrosine-protein phosphatase non-receptor type. (395 aa)
	LOC103389012	Apolipoprotein Eb. (346 aa)
	LOC103395974	C-C motif chemokine. (108 aa)
	LOC103395973	C-C motif chemokine. (102 aa)
	ENSCSEP00000023133	Uncharacterized protein. (90 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (473 aa)
	ENSCSEP00000022284	Uncharacterized protein. (65 aa)
	Traf7	TNF receptor-associated factor 7. (642 aa)
	LOC103393040	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (234 aa)
	cib1	Calcium and integrin binding 1 (calmyrin). (189 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (948 aa)
	LOC103395908	SCY domain-containing protein. (127 aa)
	dab2	DAB adaptor protein 2. (807 aa)
	ptpn2	Tyrosine-protein phosphatase non-receptor type. (417 aa)
	Garem1	GRB2 associated, regulator of MAPK1. (852 aa)
	abl2	Tyrosine-protein kinase. (1211 aa)
	serpinf2	SERPIN domain-containing protein; Belongs to the serpin family. (470 aa)
	LOC103380455	Uncharacterized protein. (387 aa)
	LOC103380461	Si:ch73-330k17.3. (159 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
	ENSCSEP00000018935	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	spry4	Sprouty homolog 4 (Drosophila). (393 aa)
	gpnmb	Glycoprotein (transmembrane) nmb. (608 aa)
	styx	Serine/threonine/tyrosine interacting protein. (223 aa)
	nod2	Nucleotide-binding oligomerization domain containing 2. (984 aa)
	LOC103379313	Uncharacterized protein; Belongs to the semaphorin family. (627 aa)
	ackr3	Atypical chemokine receptor 3a; Belongs to the G-protein coupled receptor 1 family. (404 aa)
	LOC103398511	Elastin microfibril interfacer 1a. (945 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (310 aa)
	bmper	BMP binding endothelial regulator. (716 aa)
	LOC103386316	Family with sequence similarity 83 member D. (550 aa)
	LOC103388694	Si:ch211-113g11.6; Belongs to the semaphorin family. (639 aa)
	Spry2	Sprouty RTK signaling antagonist 2. (418 aa)
	RAMP3	Receptor activity modifying protein 3. (165 aa)
	glipr2	GLI pathogenesis-related 2, like; Belongs to the CRISP family. (158 aa)
	ENSCSEP00000012763	Uncharacterized protein. (143 aa)
	Tnfrsf11a	Uncharacterized protein. (472 aa)
	nptn	Neuroplastin b. (393 aa)
	Card9	CARD domain-containing protein. (468 aa)
	Jun	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (303 aa)
	ENSCSEP00000012576	Bone morphogenetic protein 16. (516 aa)
	LOC103396898	Interleukin-1. (246 aa)
	LOC103377972	Sprouty related EVH1 domain containing 3. (519 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
	LOC103397887	Mothers against decapentaplegic homolog. (510 aa)
	LOC103399091	Ig-like domain-containing protein. (230 aa)
	sema7a	Semaphorin 7A; Belongs to the semaphorin family. (646 aa)
	LOC103395654	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	gas6	Growth arrest-specific 6. (605 aa)
	LOC103390897	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (211 aa)
	LOC103393310	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (529 aa)
	tnfaip8l3	Tumor necrosis factor, alpha-induced protein 8-like 3. (203 aa)
	LOC103391947	Si:ch211-184m13.4; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	atf3	Activating transcription factor 3. (234 aa)
	fgb	Fibrinogen beta chain. (495 aa)
	LOC103377845	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	LOC103390704	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	spry1	Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (362 aa)
	rapgef2	Rap guanine nucleotide exchange factor (GEF) 2. (1621 aa)
	ARHGAP8	Rho GTPase activating protein 8. (366 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (342 aa)
	garem2	GRB2 associated, regulator of MAPK1-like. (728 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (423 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	ENSCSEP00000004930	Uncharacterized protein. (972 aa)
	ENSCSEP00000004597	A kinase (PRKA) anchor protein 12b. (1362 aa)
	LOC103387592	Si:dkey-6n21.13; Belongs to the G-protein coupled receptor 1 family. (386 aa)
	LOC103391567	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (267 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (165 aa)
	ENSCSEP00000003368	G_PROTEIN_RECEP_F1_2 domain-containing protein. (397 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Card9	nod1	ENSCSEP00000012654	ENSCSEP00000021506	CARD domain-containing protein.	Nucleotide-binding oligomerization domain containing 1.	0.525
Card9	nod2	ENSCSEP00000012654	ENSCSEP00000017824	CARD domain-containing protein.	Nucleotide-binding oligomerization domain containing 2.	0.525
Card9	ripk2	ENSCSEP00000012654	ENSCSEP00000026837	CARD domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.947
ENSCSEP00000002689	Traf7	ENSCSEP00000002689	ENSCSEP00000022138	Uncharacterized protein.	TNF receptor-associated factor 7.	0.467
ENSCSEP00000012576	LOC103394304	ENSCSEP00000012576	ENSCSEP00000024049	Bone morphogenetic protein 16.	Mothers against decapentaplegic homolog.	0.686
ENSCSEP00000012576	LOC103397887	ENSCSEP00000012576	ENSCSEP00000010634	Bone morphogenetic protein 16.	Mothers against decapentaplegic homolog.	0.686
ENSCSEP00000012576	SMAD4	ENSCSEP00000012576	ENSCSEP00000026341	Bone morphogenetic protein 16.	Mothers against decapentaplegic homolog.	0.686
ENSCSEP00000012576	bmper	ENSCSEP00000012576	ENSCSEP00000015359	Bone morphogenetic protein 16.	BMP binding endothelial regulator.	0.493
ENSCSEP00000030876	LOC103377845	ENSCSEP00000030876	ENSCSEP00000008684	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.565
ENSCSEP00000030876	LOC103380740	ENSCSEP00000030876	ENSCSEP00000029957	Uncharacterized protein.	C-C motif chemokine.	0.533
ENSCSEP00000030876	LOC103385749	ENSCSEP00000030876	ENSCSEP00000030108	Uncharacterized protein.	SCY domain-containing protein.	0.597
ENSCSEP00000030876	LOC103395974	ENSCSEP00000030876	ENSCSEP00000023309	Uncharacterized protein.	C-C motif chemokine.	0.403
ENSCSEP00000030876	LOC103396898	ENSCSEP00000030876	ENSCSEP00000012188	Uncharacterized protein.	Interleukin-1.	0.614
ENSCSEP00000030876	LOC103397875	ENSCSEP00000030876	ENSCSEP00000032065	Uncharacterized protein.	Interleukin-1; Belongs to the IL-1 family.	0.614
ENSCSEP00000030876	cck-2	ENSCSEP00000030876	ENSCSEP00000024735	Uncharacterized protein.	CC chemokine.	0.632
ENSCSEP00000030876	dab2	ENSCSEP00000030876	ENSCSEP00000021229	Uncharacterized protein.	DAB adaptor protein 2.	0.612
ENSCSEP00000030876	ptpn11	ENSCSEP00000030876	ENSCSEP00000019044	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.585
ENSCSEP00000030876	ptpn6	ENSCSEP00000030876	ENSCSEP00000031138	Uncharacterized protein.	Protein tyrosine phosphatase non-receptor type 6.	0.585
ENSCSEP00000030876	ptprc	ENSCSEP00000030876	ENSCSEP00000025863	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.787
Fgf21	LOC103377845	ENSCSEP00000030170	ENSCSEP00000008684	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.482