(31 nodes) Negative regulation of ERK1 and ERK2 cascade network (Cynoglossus semilaevis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	itgb1bp1	Integrin beta 1 binding protein 1. (198 aa)
	errfi1	ERBB receptor feedback inhibitor 1a. (423 aa)
	ENSCSEP00000033581	Protein tyrosine phosphatase non-receptor type 1. (326 aa)
	dusp10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (487 aa)
	LOC103380805	Si:ch211-153j24.3. (365 aa)
	ENSCSEP00000030215	Inhibitor_Mig-6 domain-containing protein. (298 aa)
	flcn	Folliculin. (554 aa)
	vrk3	VRK serine/threonine kinase 3. (534 aa)
	SMAD4	Mothers against decapentaplegic homolog. (503 aa)
	phb	Prohibitin. (271 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1258 aa)
	c4h3orf33	C18h3orf33 homolog (H. sapiens). (263 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (214 aa)
	LOC103394890	Si:dkey-175m17.7. (878 aa)
	LOC103394304	Mothers against decapentaplegic homolog. (573 aa)
	LOC103394276	Tyrosine-protein phosphatase non-receptor type. (395 aa)
	dab2	DAB adaptor protein 2. (807 aa)
	ptpn2	Tyrosine-protein phosphatase non-receptor type. (417 aa)
	ENSCSEP00000018935	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	spry4	Sprouty homolog 4 (Drosophila). (393 aa)
	LOC103398511	Elastin microfibril interfacer 1a. (945 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (310 aa)
	Spry2	Sprouty RTK signaling antagonist 2. (418 aa)
	ENSCSEP00000002689	Uncharacterized protein. (334 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (165 aa)
	ENSCSEP00000004930	Uncharacterized protein. (972 aa)
	spry1	Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (362 aa)
	atf3	Activating transcription factor 3. (234 aa)
	LOC103397887	Mothers against decapentaplegic homolog. (510 aa)
	LOC103377972	Sprouty related EVH1 domain containing 3. (519 aa)
	ENSCSEP00000012763	Uncharacterized protein. (143 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103394304	LOC103397887	ENSCSEP00000024049	ENSCSEP00000010634	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
LOC103394304	SMAD4	ENSCSEP00000024049	ENSCSEP00000026341	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
LOC103397887	LOC103394304	ENSCSEP00000010634	ENSCSEP00000024049	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
LOC103397887	SMAD4	ENSCSEP00000010634	ENSCSEP00000026341	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.900
SMAD4	LOC103394304	ENSCSEP00000026341	ENSCSEP00000024049	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
SMAD4	LOC103397887	ENSCSEP00000026341	ENSCSEP00000010634	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.900
SPRY3	spry1	ENSCSEP00000016234	ENSCSEP00000006957	Sprouty RTK signaling antagonist 3.	Sprouty homolog 1, antagonist of FGF signaling (Drosophila).	0.559
Spry2	spry1	ENSCSEP00000014660	ENSCSEP00000006957	Sprouty RTK signaling antagonist 2.	Sprouty homolog 1, antagonist of FGF signaling (Drosophila).	0.646
spry1	SPRY3	ENSCSEP00000006957	ENSCSEP00000016234	Sprouty homolog 1, antagonist of FGF signaling (Drosophila).	Sprouty RTK signaling antagonist 3.	0.559
spry1	Spry2	ENSCSEP00000006957	ENSCSEP00000014660	Sprouty homolog 1, antagonist of FGF signaling (Drosophila).	Sprouty RTK signaling antagonist 2.	0.646
spry1	spry4	ENSCSEP00000006957	ENSCSEP00000018911	Sprouty homolog 1, antagonist of FGF signaling (Drosophila).	Sprouty homolog 4 (Drosophila).	0.586
spry4	spry1	ENSCSEP00000018911	ENSCSEP00000006957	Sprouty homolog 4 (Drosophila).	Sprouty homolog 1, antagonist of FGF signaling (Drosophila).	0.586