(104 nodes) Negative regulation of canonical Wnt signaling pathway network (Cynoglossus semilaevis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	igfbp6	Insulin-like growth factor binding protein 6b. (209 aa)
	LOC103386321	Cylindromatosis (turban tumor syndrome), b. (617 aa)
	LOC103390961	Uncharacterized protein. (245 aa)
	tmem170b	Transmembrane protein 170B. (160 aa)
	lzts2	Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (690 aa)
	ENSCSEP00000016689	Mesoderm posterior ba. (251 aa)
	ddit3	DNA-damage-inducible transcript 3. (315 aa)
	ENSCSEP00000017247	Transmembrane protein 88 a. (225 aa)
	notum	Notum, palmitoleoyl-protein carboxylesterase a. (497 aa)
	nkd1	NKD inhibitor of WNT signaling pathway 1. (448 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate b. (474 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (966 aa)
	LOC103384064	Notum pectinacetylesterase 2. (578 aa)
	Dact1	Uncharacterized protein. (587 aa)
	LOC103395263	LRRCT domain-containing protein. (358 aa)
	LOC103379113	Uncharacterized protein. (785 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	LOC103394470	CTCK domain-containing protein. (225 aa)
	ankrd6	Ankyrin repeat domain 6b. (676 aa)
	ENSCSEP00000028514	TLE_N domain-containing protein. (78 aa)
	LOC103398412	Dickkopf WNT signaling pathway inhibitor 3a. (293 aa)
	LOC103387999	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (441 aa)
	LOC103395031	Dishevelled-binding antagonist of beta-catenin 3a. (694 aa)
	LOC103378548	Uncharacterized protein. (343 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (533 aa)
	LOC103394421	Uncharacterized protein. (320 aa)
	lzts3	Leucine zipper, putative tumor suppressor family member 3b. (1059 aa)
	tmem64	Transmembrane protein 64. (350 aa)
	LOC103384550	Uncharacterized protein. (1008 aa)
	LOC103396896	RING-type domain-containing protein. (872 aa)
	ENSCSEP00000013053	WD_REPEATS_REGION domain-containing protein. (331 aa)
	LOC103394676	Trophoblast glycoprotein a. (373 aa)
	dab2	DAB adaptor protein 2. (807 aa)
	ENSCSEP00000026811	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (455 aa)
	LOC103379702	Dickkopf WNT signaling pathway inhibitor 3b. (243 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	VANGL2	Vang-like protein. (525 aa)
	axin1	Axin 1. (810 aa)
	chd8	Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2592 aa)
	LOC103397863	Zinc and ring finger 3. (894 aa)
	kremen1	Kringle containing transmembrane protein 1. (475 aa)
	csnk1a1	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (353 aa)
	LOC103393872	Glycogen synthase kinase 3 alpha a. (655 aa)
	Apc	APC_N_CC domain-containing protein. (270 aa)
	nkx2-5	NK2 homeobox 5. (329 aa)
	LOC103391414	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	ENSCSEP00000031320	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
	cby1	Chibby homolog 1 (Drosophila). (135 aa)
	ushbp1	Usher syndrome 1C binding protein 1. (688 aa)
	LOC103387688	Dickkopf WNT signaling pathway inhibitor 1a. (253 aa)
	frmd8	FERM domain containing 8. (468 aa)
	LOC103389012	Apolipoprotein Eb. (346 aa)
	AXIN2	Axin 2. (792 aa)
	LOC103393014	Axin 2 (conductin, axil). (839 aa)
	sostdc1	Sclerostin domain containing 1a. (221 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (436 aa)
	LOC103397412	Secreted frizzled-related protein 1a. (299 aa)
	LOC103395289	APC membrane recruitment protein 1. (970 aa)
	sox13	SRY-box transcription factor 13. (635 aa)
	amer2	APC membrane recruitment protein 2. (686 aa)
	tpbg	Trophoblast glycoprotein b. (380 aa)
	lats2	Large tumor suppressor kinase 2. (1178 aa)
	rspo3	R-spondin 3. (330 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (186 aa)
	LOC103385960	Vang-like protein. (528 aa)
	LOC103398303	TLE family member 2, transcriptional corepressor a. (780 aa)
	ENSCSEP00000000473	TLE family member 2, transcriptional corepressor b. (352 aa)
	ENSCSEP00000000482	TLE_N domain-containing protein. (95 aa)
	TLE5	TLE family member 5, transcriptional modulator. (174 aa)
	apc2	APC regulator of WNT signaling pathway 2. (2212 aa)
	ENSCSEP00000001251	Frizzled related protein. (256 aa)
	lmbr1	Limb development membrane protein 1; Belongs to the LIMR family. (488 aa)
	ENSCSEP00000003110	Uncharacterized protein. (819 aa)
	dact3	Uncharacterized protein. (642 aa)
	nog	Noggin; Belongs to the noggin family. (224 aa)
	LOC103399892	Cylindromatosis (turban tumor syndrome), like. (790 aa)
	dkk2	Dickkopf WNT signaling pathway inhibitor 2. (245 aa)
	ubac2	UBA domain containing 2. (322 aa)
	ENSCSEP00000004785	Shisa family member 3. (111 aa)
	SHISA3	Shisa family member 3. (238 aa)
	pfdn5	Prefoldin 5. (155 aa)
	lats1	Large tumor suppressor kinase 1. (1109 aa)
	LOC103381185	Gremlin 1a, DAN family BMP antagonist. (182 aa)
	nphp4	Uncharacterized protein. (1428 aa)
	tmem131l	Transmembrane 131 like. (1510 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (447 aa)
	nkd2	NKD inhibitor of WNT signaling pathway 2a. (460 aa)
	LOC103387202	Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (775 aa)
	bicc1	BicC family RNA binding protein 1a. (982 aa)
	LOC103379965	TLE_N domain-containing protein. (203 aa)
	LOC103388466	Trophoblast glycoprotein-like. (400 aa)
	LOC103389499	Dickkopf_N domain-containing protein. (382 aa)
	ctnnbip1	Catenin, beta interacting protein 1. (81 aa)
	scyl2	SCY1 like pseudokinase 2. (915 aa)
	LOC103390901	Bicaudal C homolog 2. (921 aa)
	sfrp5	Secreted frizzled-related protein 5. (319 aa)
	TLE1	Uncharacterized protein. (737 aa)
	lmbr1l	Limb development membrane protein 1-like; Belongs to the LIMR family. (492 aa)
	LOC103380252	TLE family member 3, transcriptional corepressor. (769 aa)
	ENSCSEP00000011179	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (240 aa)
	LOC103380347	Sizzled. (283 aa)
	LOC103397916	Uncharacterized protein. (762 aa)
	ENSCSEP00000012111	Kringle containing transmembrane protein 1. (454 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	Apc	ENSCSEP00000023130	ENSCSEP00000031818	Axin 2.	APC_N_CC domain-containing protein.	0.981
AXIN2	ENSCSEP00000031320	ENSCSEP00000023130	ENSCSEP00000031320	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.496
AXIN2	LOC103387999	ENSCSEP00000023130	ENSCSEP00000030481	Axin 2.	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	0.800
AXIN2	LOC103391414	ENSCSEP00000023130	ENSCSEP00000031355	Axin 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.496
AXIN2	LOC103393014	ENSCSEP00000023130	ENSCSEP00000022690	Axin 2.	Axin 2 (conductin, axil).	0.902
AXIN2	LOC103393872	ENSCSEP00000023130	ENSCSEP00000031838	Axin 2.	Glycogen synthase kinase 3 alpha a.	0.800
AXIN2	LOC103395289	ENSCSEP00000023130	ENSCSEP00000021453	Axin 2.	APC membrane recruitment protein 1.	0.784
AXIN2	ankrd6	ENSCSEP00000023130	ENSCSEP00000028658	Axin 2.	Ankyrin repeat domain 6b.	0.402
AXIN2	apc2	ENSCSEP00000023130	ENSCSEP00000000636	Axin 2.	APC regulator of WNT signaling pathway 2.	0.823
AXIN2	axin1	ENSCSEP00000023130	ENSCSEP00000033046	Axin 2.	Axin 1.	0.923
AXIN2	csnk1a1	ENSCSEP00000023130	ENSCSEP00000032141	Axin 2.	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.	0.983
AXIN2	gsk3b	ENSCSEP00000023130	ENSCSEP00000017793	Axin 2.	Glycogen synthase kinase 3 beta, genome duplicate b.	0.982
AXIN2	sfrp5	ENSCSEP00000023130	ENSCSEP00000010130	Axin 2.	Secreted frizzled-related protein 5.	0.400
AXIN2	stk11	ENSCSEP00000023130	ENSCSEP00000022612	Axin 2.	Serine/threonine kinase 11; Belongs to the protein kinase superfamily.	0.440
Apc	AXIN2	ENSCSEP00000031818	ENSCSEP00000023130	APC_N_CC domain-containing protein.	Axin 2.	0.981
Apc	ENSCSEP00000003110	ENSCSEP00000031818	ENSCSEP00000003110	APC_N_CC domain-containing protein.	Uncharacterized protein.	0.827
Apc	ENSCSEP00000031320	ENSCSEP00000031818	ENSCSEP00000031320	APC_N_CC domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.444
Apc	LOC103387999	ENSCSEP00000031818	ENSCSEP00000030481	APC_N_CC domain-containing protein.	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	0.820
Apc	LOC103391414	ENSCSEP00000031818	ENSCSEP00000031355	APC_N_CC domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.444
Apc	LOC103393014	ENSCSEP00000031818	ENSCSEP00000022690	APC_N_CC domain-containing protein.	Axin 2 (conductin, axil).	0.981