STRINGSTRING
pan3 pan3 LOC103390172 LOC103390172 ENSCSEP00000025902 ENSCSEP00000025902 dcp2 dcp2 LOC103391308 LOC103391308 pde12 pde12 dis3l2 dis3l2 zc3h12a zc3h12a exosc8 exosc8 LOC103383092 LOC103383092 cnot8 cnot8 toe1 toe1 pan2 pan2 xrn1 xrn1 angel1 angel1 PNPT1 PNPT1 CPSF3 CPSF3 eri2 eri2 parn parn dis3 dis3 LOC103381275 LOC103381275 gnl3 gnl3 exosc10 exosc10 exosc3 exosc3 ENSCSEP00000008800 ENSCSEP00000008800 ENSCSEP00000008806 ENSCSEP00000008806 eri1 eri1 rexo2 rexo2 dis3l dis3l exd2 exd2 LOC103394027 LOC103394027 LOC103397020 LOC103397020 LOC103390988 LOC103390988 exosc7 exosc7 usb1 usb1 cnot6l cnot6l noct noct exosc9 exosc9 trir trir Cnot2 Cnot2 cnot2 cnot2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pan3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (794 aa)
LOC103390172Exosome component 2. (291 aa)
ENSCSEP00000025902Exosome component 2. (135 aa)
dcp2Decapping mRNA 2. (390 aa)
LOC103391308CCR4-NOT transcription complex, subunit 7. (286 aa)
pde12Phosphodiesterase 12. (558 aa)
dis3l2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (1034 aa)
zc3h12aZinc finger CCCH-type containing 12A. (592 aa)
exosc8Exosome component 8. (277 aa)
LOC103383092NOT2_3_5 domain-containing protein. (564 aa)
cnot8CCR4-NOT transcription complex, subunit 8. (286 aa)
toe1Target of EGR1, exonuclease. (527 aa)
pan2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1195 aa)
xrn15'-3' exoribonuclease 1. (1618 aa)
angel1Angel homolog 1 (Drosophila). (683 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (703 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (690 aa)
eri2ERI1 exoribonuclease family member 2. (727 aa)
parnPoly(A)-specific ribonuclease (deadenylation nuclease). (692 aa)
dis3DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (948 aa)
LOC103381275Angel homolog 2 (Drosophila). (553 aa)
gnl3Guanine nucleotide binding protein-like 3 (nucleolar). (547 aa)
exosc10Exosome component 10. (896 aa)
exosc3Exosome component 3. (244 aa)
ENSCSEP000000088005'-3' exoribonuclease 2. (496 aa)
ENSCSEP00000008806XRN_M domain-containing protein. (313 aa)
eri1Exoribonuclease 1. (340 aa)
rexo2Small fragment nuclease. (277 aa)
dis3lDIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (1047 aa)
exd2Exonuclease 3'-5' domain containing 2. (728 aa)
LOC103394027Si:dkey-206d17.12. (638 aa)
LOC103397020Endo/exonuclease/phosphatase domain-containing protein. (426 aa)
LOC103390988CCR4-NOT transcription complex, subunit 6a. (559 aa)
exosc7Exosome component 7. (291 aa)
usb1U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (276 aa)
cnot6lCCR4-NOT transcription complex, subunit 6-like. (553 aa)
noctNocturnin a. (384 aa)
exosc9Exosome component 9. (400 aa)
trirTelomerase RNA component interacting RNase. (150 aa)
Cnot2Uncharacterized protein. (75 aa)
cnot2CCR4-NOT transcription complex, subunit 2. (484 aa)
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
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