(23 nodes) Energy homeostasis network (Cynoglossus semilaevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLC35D3	Solute carrier family 35 member D3. (437 aa)
	oma1	OMA1 zinc metallopeptidase. (516 aa)
	LOC103388356	Nuclear receptor subfamily 1, group D, member 2a. (617 aa)
	LOC103385997	Nuclear receptor subfamily 1, group D, member 4b. (574 aa)
	nmu	NMU domain-containing protein. (167 aa)
	ENSCSEP00000002138	Melanocortin 4 receptor. (319 aa)
	tsku	Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis). (347 aa)
	LOC103380944	Melanocortin 2 receptor accessory protein 2b. (236 aa)
	pm20d1	Peptidase M20 domain containing 1, tandem duplicate 2. (508 aa)
	flcn	Folliculin. (554 aa)
	CRTC1	CREB regulated transcription coactivator 1b. (604 aa)
	lepr	Leptin receptor. (1148 aa)
	sirt1	Sirtuin 1. (647 aa)
	Pask	Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (388 aa)
	LOC103390073	Non-specific serine/threonine protein kinase. (574 aa)
	LOC103395874	Uncharacterized protein. (580 aa)
	irx3	Iroquois homeobox 3a. (431 aa)
	metrnl	Meteorin like, glial cell differentiation regulator a. (288 aa)
	LOC103385110	Nuclear receptor subfamily 1, group D, member 4a. (576 aa)
	Rrp8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (380 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (1262 aa)
	sqstm1	Sequestosome 1. (427 aa)
	Prkaa2	Non-specific serine/threonine protein kinase. (551 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSEP00000002138	LOC103380944	ENSCSEP00000002138	ENSCSEP00000032684	Melanocortin 4 receptor.	Melanocortin 2 receptor accessory protein 2b.	0.609
ENSCSEP00000002138	lepr	ENSCSEP00000002138	ENSCSEP00000027750	Melanocortin 4 receptor.	Leptin receptor.	0.786
LOC103380944	ENSCSEP00000002138	ENSCSEP00000032684	ENSCSEP00000002138	Melanocortin 2 receptor accessory protein 2b.	Melanocortin 4 receptor.	0.609
LOC103390073	Prkaa2	ENSCSEP00000023346	ENSCSEP00000006716	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.917
LOC103390073	sirt1	ENSCSEP00000023346	ENSCSEP00000027127	Non-specific serine/threonine protein kinase.	Sirtuin 1.	0.506
Prkaa2	LOC103390073	ENSCSEP00000006716	ENSCSEP00000023346	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.917
Prkaa2	sirt1	ENSCSEP00000006716	ENSCSEP00000027127	Non-specific serine/threonine protein kinase.	Sirtuin 1.	0.506
Rrp8	sirt1	ENSCSEP00000011398	ENSCSEP00000027127	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Sirtuin 1.	0.889
lepr	ENSCSEP00000002138	ENSCSEP00000027750	ENSCSEP00000002138	Leptin receptor.	Melanocortin 4 receptor.	0.786
metrnl	sirt1	ENSCSEP00000014076	ENSCSEP00000027127	Meteorin like, glial cell differentiation regulator a.	Sirtuin 1.	0.467
ppargc1a	sirt1	ENSCSEP00000010745	ENSCSEP00000027127	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.	Sirtuin 1.	0.784
sirt1	LOC103390073	ENSCSEP00000027127	ENSCSEP00000023346	Sirtuin 1.	Non-specific serine/threonine protein kinase.	0.506
sirt1	Prkaa2	ENSCSEP00000027127	ENSCSEP00000006716	Sirtuin 1.	Non-specific serine/threonine protein kinase.	0.506
sirt1	Rrp8	ENSCSEP00000027127	ENSCSEP00000011398	Sirtuin 1.	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	0.889
sirt1	metrnl	ENSCSEP00000027127	ENSCSEP00000014076	Sirtuin 1.	Meteorin like, glial cell differentiation regulator a.	0.467
sirt1	ppargc1a	ENSCSEP00000027127	ENSCSEP00000010745	Sirtuin 1.	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.	0.784