(16 nodes) Extrinsic apoptotic signaling pathway in absence of ligand network (Cynoglossus semilaevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSCSEP00000015414	BH4_2 domain-containing protein. (214 aa)
	bcl2l1	BCL2 like 1. (235 aa)
	Nf1	Neurofibromin 1b. (2702 aa)
	ENSCSEP00000010887	Uncharacterized protein. (193 aa)
	bok	BCL2 family apoptosis regulator BOK a. (210 aa)
	LOC103388701	MCL1 apoptosis regulator, BCL2 family member b. (304 aa)
	Bag3	WW domain-containing protein. (189 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate b. (474 aa)
	LOC103379424	BCL2 like 10. (217 aa)
	ENSCSEP00000021188	Uncharacterized protein. (190 aa)
	LOC103396062	BCL2 family apoptosis regulator BOK b. (213 aa)
	bad	BCL2 associated agonist of cell death b. (178 aa)
	LOC103387999	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (441 aa)
	casp2	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (463 aa)
	LOC103393872	Glycogen synthase kinase 3 alpha a. (655 aa)
	bax	BCL2 associated X, apoptosis regulator a. (192 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSEP00000010887	LOC103388701	ENSCSEP00000010887	ENSCSEP00000014888	Uncharacterized protein.	MCL1 apoptosis regulator, BCL2 family member b.	0.902
ENSCSEP00000010887	bad	ENSCSEP00000010887	ENSCSEP00000026457	Uncharacterized protein.	BCL2 associated agonist of cell death b.	0.720
ENSCSEP00000010887	bax	ENSCSEP00000010887	ENSCSEP00000033138	Uncharacterized protein.	BCL2 associated X, apoptosis regulator a.	0.864
ENSCSEP00000010887	bok	ENSCSEP00000010887	ENSCSEP00000013474	Uncharacterized protein.	BCL2 family apoptosis regulator BOK a.	0.456
ENSCSEP00000015414	LOC103379424	ENSCSEP00000015414	ENSCSEP00000020490	BH4_2 domain-containing protein.	BCL2 like 10.	0.453
ENSCSEP00000015414	bad	ENSCSEP00000015414	ENSCSEP00000026457	BH4_2 domain-containing protein.	BCL2 associated agonist of cell death b.	0.992
ENSCSEP00000015414	bax	ENSCSEP00000015414	ENSCSEP00000033138	BH4_2 domain-containing protein.	BCL2 associated X, apoptosis regulator a.	0.989
ENSCSEP00000015414	bcl2l1	ENSCSEP00000015414	ENSCSEP00000004560	BH4_2 domain-containing protein.	BCL2 like 1.	0.902
ENSCSEP00000015414	casp2	ENSCSEP00000015414	ENSCSEP00000031528	BH4_2 domain-containing protein.	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.513
ENSCSEP00000021188	bad	ENSCSEP00000021188	ENSCSEP00000026457	Uncharacterized protein.	BCL2 associated agonist of cell death b.	0.720
ENSCSEP00000021188	bax	ENSCSEP00000021188	ENSCSEP00000033138	Uncharacterized protein.	BCL2 associated X, apoptosis regulator a.	0.864
ENSCSEP00000021188	bok	ENSCSEP00000021188	ENSCSEP00000013474	Uncharacterized protein.	BCL2 family apoptosis regulator BOK a.	0.456
LOC103379424	ENSCSEP00000015414	ENSCSEP00000020490	ENSCSEP00000015414	BCL2 like 10.	BH4_2 domain-containing protein.	0.453
LOC103379424	bad	ENSCSEP00000020490	ENSCSEP00000026457	BCL2 like 10.	BCL2 associated agonist of cell death b.	0.720
LOC103379424	bcl2l1	ENSCSEP00000020490	ENSCSEP00000004560	BCL2 like 10.	BCL2 like 1.	0.453
LOC103379424	bok	ENSCSEP00000020490	ENSCSEP00000013474	BCL2 like 10.	BCL2 family apoptosis regulator BOK a.	0.434
LOC103388701	ENSCSEP00000010887	ENSCSEP00000014888	ENSCSEP00000010887	MCL1 apoptosis regulator, BCL2 family member b.	Uncharacterized protein.	0.902
LOC103388701	bad	ENSCSEP00000014888	ENSCSEP00000026457	MCL1 apoptosis regulator, BCL2 family member b.	BCL2 associated agonist of cell death b.	0.720
LOC103388701	bax	ENSCSEP00000014888	ENSCSEP00000033138	MCL1 apoptosis regulator, BCL2 family member b.	BCL2 associated X, apoptosis regulator a.	0.864
LOC103388701	bok	ENSCSEP00000014888	ENSCSEP00000013474	MCL1 apoptosis regulator, BCL2 family member b.	BCL2 family apoptosis regulator BOK a.	0.456