(22 nodes) Site of double-strand break network (Cynoglossus semilaevis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	iffo2	Intermediate filament family orphan 2b; Belongs to the intermediate filament family. (464 aa)
	samhd1	SAM domain and HD domain 1. (592 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa)
	iffo1	Intermediate filament family orphan 1b; Belongs to the intermediate filament family. (558 aa)
	LOC103398305	Uncharacterized protein. (1059 aa)
	ENSCSEP00000026980	SET domain and mariner transposase fusion gene. (313 aa)
	ENSCSEP00000026879	Uncharacterized protein. (228 aa)
	WDR70	WD repeat domain 70. (422 aa)
	LOC103392345	Actin related protein 3; Belongs to the actin family. (418 aa)
	LOC103378278	Polynucleotide kinase 3'-phosphatase. (591 aa)
	LOC103397224	Uncharacterized protein. (1046 aa)
	slf1	Uncharacterized protein. (788 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1101 aa)
	LOC103398007	Uncharacterized protein. (287 aa)
	Rnf168	RING-type domain-containing protein. (117 aa)
	LOC103387312	Uncharacterized protein. (1150 aa)
	Rnf169	Ring finger protein 169. (665 aa)
	shld2	Si:ch211-134m17.9. (741 aa)
	ACTR3	Uncharacterized protein; Belongs to the actin family. (418 aa)
	Parp3	Poly [ADP-ribose] polymerase. (514 aa)
	tonsl	Tonsoku-like, DNA repair protein. (1433 aa)
	ENSCSEP00000001772	Uncharacterized protein. (178 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTR3	LOC103392345	ENSCSEP00000005397	ENSCSEP00000023934	Uncharacterized protein; Belongs to the actin family.	Actin related protein 3; Belongs to the actin family.	0.652
ENSCSEP00000001772	LOC103378278	ENSCSEP00000001772	ENSCSEP00000022883	Uncharacterized protein.	Polynucleotide kinase 3'-phosphatase.	0.573
ENSCSEP00000001772	Parp3	ENSCSEP00000001772	ENSCSEP00000004002	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.736
LOC103378278	ENSCSEP00000001772	ENSCSEP00000022883	ENSCSEP00000001772	Polynucleotide kinase 3'-phosphatase.	Uncharacterized protein.	0.573
LOC103392345	ACTR3	ENSCSEP00000023934	ENSCSEP00000005397	Actin related protein 3; Belongs to the actin family.	Uncharacterized protein; Belongs to the actin family.	0.652
LOC103397224	tp53bp1	ENSCSEP00000022643	ENSCSEP00000015332	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.483
LOC103398007	shld2	ENSCSEP00000015319	ENSCSEP00000006486	Uncharacterized protein.	Si:ch211-134m17.9.	0.934
LOC103398305	tp53bp1	ENSCSEP00000028025	ENSCSEP00000015332	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.483
Parp3	ENSCSEP00000001772	ENSCSEP00000004002	ENSCSEP00000001772	Poly [ADP-ribose] polymerase.	Uncharacterized protein.	0.736
Rnf168	Rnf169	ENSCSEP00000013875	ENSCSEP00000009432	RING-type domain-containing protein.	Ring finger protein 169.	0.607
Rnf168	rnf8	ENSCSEP00000013875	ENSCSEP00000032366	RING-type domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.858
Rnf168	tp53bp1	ENSCSEP00000013875	ENSCSEP00000015332	RING-type domain-containing protein.	Tumor protein p53 binding protein, 1.	0.958
Rnf169	Rnf168	ENSCSEP00000009432	ENSCSEP00000013875	Ring finger protein 169.	RING-type domain-containing protein.	0.607
Rnf169	rnf8	ENSCSEP00000009432	ENSCSEP00000032366	Ring finger protein 169.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.738
Rnf169	tp53bp1	ENSCSEP00000009432	ENSCSEP00000015332	Ring finger protein 169.	Tumor protein p53 binding protein, 1.	0.845
rnf8	Rnf168	ENSCSEP00000032366	ENSCSEP00000013875	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	RING-type domain-containing protein.	0.858
rnf8	Rnf169	ENSCSEP00000032366	ENSCSEP00000009432	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Ring finger protein 169.	0.738
rnf8	tonsl	ENSCSEP00000032366	ENSCSEP00000003856	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Tonsoku-like, DNA repair protein.	0.482
rnf8	tp53bp1	ENSCSEP00000032366	ENSCSEP00000015332	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	Tumor protein p53 binding protein, 1.	0.903
shld2	LOC103398007	ENSCSEP00000006486	ENSCSEP00000015319	Si:ch211-134m17.9.	Uncharacterized protein.	0.934