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shld2 shld2 ENSCSEP00000033782 ENSCSEP00000033782 rps11 rps11 rmi2 rmi2 mcm2 mcm2 Mcm10 Mcm10 LOC103382071 LOC103382071 psmc3 psmc3 ybx1 ybx1 rpa2 rpa2 lin28a lin28a psmc1 psmc1 Mcm6 Mcm6 dis3l2 dis3l2 mrps17 mrps17 rps23 rps23 ENSCSEP00000028391 ENSCSEP00000028391 nabp1 nabp1 mcm8 mcm8 dars2 dars2 eif1ad eif1ad LOC103382982 LOC103382982 carhsp1 carhsp1 LOC103390172 LOC103390172 zcchc17 zcchc17 Nars Nars LOC103377182 LOC103377182 psmc6 psmc6 eif1ax eif1ax polr2h polr2h spout1 spout1 LOC103381856 LOC103381856 mrpl2 mrpl2 lig3 lig3 ENSCSEP00000022777 ENSCSEP00000022777 dars1 dars1 LOC103395296 LOC103395296 Lig4 Lig4 helz2 helz2 rpa1 rpa1 LOC103395242 LOC103395242 psmc4 psmc4 polr2g polr2g rps28 rps28 stn1 stn1 pdcd11 pdcd11 mcm3 mcm3 mcm4 mcm4 yars1 yars1 ENSCSEP00000013277 ENSCSEP00000013277 kars1 kars1 ten1 ten1 dis3l dis3l exosc1 exosc1 CSDC2 CSDC2 polr3h polr3h ccar1 ccar1 LOC103399068 LOC103399068 ENSCSEP00000009964 ENSCSEP00000009964 LOC103381415 LOC103381415 ssbp1 ssbp1 exosc3 exosc3 nars2 nars2 LOC103389493 LOC103389493 rpl8 rpl8 ENSCSEP00000006831 ENSCSEP00000006831 rngtt rngtt Eif2s1 Eif2s1 mcm7 mcm7 dis3 dis3 aimp1 aimp1 CSDE1 CSDE1 YBX2 YBX2 EIF5AL1 EIF5AL1 ttc14 ttc14 Pot1 Pot1 ENSCSEP00000001856 ENSCSEP00000001856 mrps12 mrps12 meiob meiob srbd1 srbd1 PNPT1 PNPT1 lin28b lin28b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
shld2Si:ch211-134m17.9. (741 aa)
ENSCSEP00000033782DNA ligase. (633 aa)
rps11Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. (169 aa)
rmi2RecQ mediated genome instability 2. (163 aa)
mcm2DNA helicase; Belongs to the MCM family. (885 aa)
Mcm10Zf-primase domain-containing protein. (203 aa)
LOC103382071Cold shock domain containing C2, RNA binding a. (158 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (404 aa)
ybx1Y box binding protein 1. (302 aa)
rpa2Replication protein A2. (274 aa)
lin28aLin-28 homolog A. (202 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
Mcm6DNA helicase; Belongs to the MCM family. (688 aa)
dis3l2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily. (1034 aa)
mrps17Mitochondrial ribosomal protein S17. (146 aa)
rps23Ribosomal protein S23; Belongs to the universal ribosomal protein uS12 family. (143 aa)
ENSCSEP00000028391Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1496 aa)
nabp1Nucleic acid binding protein 1a. (219 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (859 aa)
dars2Aspartyl-tRNA synthetase 2, mitochondrial. (673 aa)
eif1adEukaryotic translation initiation factor 1A domain containing. (166 aa)
LOC103382982Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
carhsp1Calcium regulated heat stable protein 1. (161 aa)
LOC103390172Exosome component 2. (291 aa)
zcchc17Zinc finger, CCHC domain containing 17. (241 aa)
NarsAsparaginyl-tRNA synthetase. (555 aa)
LOC103377182Eukaryotic translation initiation factor 5A. (154 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (407 aa)
eif1axEukaryotic translation initiation factor 1A X-linked b; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (144 aa)
polr2hDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (155 aa)
spout1SPOUT domain containing methyltransferase 1. (343 aa)
LOC103381856DEAH (Asp-Glu-Ala-His) box polypeptide 8. (1209 aa)
mrpl2Mitochondrial ribosomal protein L2. (297 aa)
lig3DNA ligase. (1015 aa)
ENSCSEP00000022777DNA helicase; Belongs to the MCM family. (683 aa)
dars1Aspartyl-tRNA synthetase. (531 aa)
LOC103395296RPA1 related single stranded DNA binding protein. (791 aa)
Lig4DNA ligase. (922 aa)
helz2Uncharacterized protein. (2846 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
LOC103395242Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (633 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
polr2gPolymerase (RNA) II (DNA directed) polypeptide G-like. (190 aa)
rps28Ribosomal protein S28. (69 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (366 aa)
pdcd11Programmed cell death 11. (1762 aa)
mcm3DNA helicase; Belongs to the MCM family. (813 aa)
mcm4DNA helicase; Belongs to the MCM family. (859 aa)
yars1Tyrosine--tRNA ligase. (553 aa)
ENSCSEP00000013277Rep_fac-A_C domain-containing protein. (470 aa)
kars1Lysine--tRNA ligase. (611 aa)
ten1TEN1 subunit of CST complex. (133 aa)
dis3lDIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (1047 aa)
exosc1Exosome component 1. (175 aa)
CSDC2Cold shock domain containing C2. (155 aa)
polr3hPolymerase (RNA) III (DNA directed) polypeptide H. (212 aa)
ccar1Cell division cycle and apoptosis regulator 1. (1119 aa)
LOC103399068Ribosomal_L2 domain-containing protein. (114 aa)
ENSCSEP00000009964Uncharacterized protein. (85 aa)
LOC103381415Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (398 aa)
ssbp1Mitochondrial single-stranded DNA-binding protein. (147 aa)
exosc3Exosome component 3. (244 aa)
nars2Asparaginyl-tRNA synthetase 2, mitochondrial. (488 aa)
LOC103389493Aminoacyl tRNA synthetase complex interacting multifunctional protein 1b. (322 aa)
rpl8Ribosomal protein L8. (257 aa)
ENSCSEP00000006831Uncharacterized protein. (1708 aa)
rngttPolynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. (601 aa)
Eif2s1Eukaryotic translation initiation factor 2, subunit 1 alpha b. (384 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
dis3DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (948 aa)
aimp1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1a. (334 aa)
CSDE1Cold shock domain containing E1, RNA-binding. (917 aa)
YBX2Y-box binding protein 2. (315 aa)
EIF5AL1Eukaryotic translation initiation factor 5A. (177 aa)
ttc14Tetratricopeptide repeat domain 14. (795 aa)
Pot1Telo_bind domain-containing protein. (323 aa)
ENSCSEP00000001856Uncharacterized protein. (246 aa)
mrps12Mitochondrial ribosomal protein S12; Belongs to the universal ribosomal protein uS12 family. (143 aa)
meiobMethionine sulfoxide reductase B1b. (436 aa)
srbd1S1 motif domain-containing protein. (997 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (703 aa)
lin28bLin-28 homolog B (C. elegans). (236 aa)
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
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