STRINGSTRING
hsp90b1 hsp90b1 exosc4 exosc4 exosc7 exosc7 top2a top2a galk2 galk2 gfm2 gfm2 eef2 eef2 lonp2 lonp2 exosc6 exosc6 exosc9 exosc9 top2b top2b rps2 rps2 galk1 galk1 eftud2 eftud2 trap1 trap1 gfm1 gfm1 mlh1 mlh1 mvk mvk exosc8 exosc8 lonp1 lonp1 LOC103380891 LOC103380891 Fuk Fuk mrps5 mrps5 LOC103380988 LOC103380988 mlh3 mlh3 pms2 pms2 PNPT1 PNPT1 LOC103380989 LOC103380989 LOC103399931 LOC103399931 mrps9 mrps9 impact impact LOC103382555 LOC103382555 LOC103377793 LOC103377793 EFL1 EFL1 mvd mvd exosc5 exosc5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hsp90b1Heat shock protein 90, beta (grp94), member 1. (810 aa)
exosc4Exosome component 4. (245 aa)
exosc7Exosome component 7. (291 aa)
top2aDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1549 aa)
galk2Galactokinase 2. (458 aa)
gfm2Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (768 aa)
eef2Eukaryotic translation elongation factor 2b. (846 aa)
lonp2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256|PROSITE-. (839 aa)
exosc6Exosome component 6. (270 aa)
exosc9Exosome component 9. (400 aa)
top2bDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1467 aa)
rps2Ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family. (279 aa)
galk1Galactokinase 1. (395 aa)
eftud2Elongation factor Tu GTP binding domain containing 2. (971 aa)
trap1TNF receptor-associated protein 1. (719 aa)
gfm1Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mito [...] (690 aa)
mlh1MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (749 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (397 aa)
exosc8Exosome component 8. (277 aa)
lonp1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (991 aa)
LOC103380891Heat shock protein 90, alpha (cytosolic), class B member 1. (733 aa)
FukFucose kinase. (1081 aa)
mrps5Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family. (406 aa)
LOC103380988Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2. (728 aa)
mlh3MutL homolog 3 (E. coli). (1127 aa)
pms2PMS1 homolog 2, mismatch repair system component. (849 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (703 aa)
LOC103380989Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (724 aa)
LOC103399931Tr-type G domain-containing protein. (860 aa)
mrps9Mitochondrial ribosomal protein S9. (417 aa)
impactImpact RWD domain protein. (331 aa)
LOC103382555Ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family. (146 aa)
LOC103377793Glucuronokinase with putative uridyl pyrophosphorylase. (478 aa)
EFL1Elongation factor like GTPase 1. (1106 aa)
mvdDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (403 aa)
exosc5Exosome component 5. (219 aa)
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.