13 items (Cynoglossus semilaevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rhbdf1	Rhomboid 5 homolog 1a (Drosophila). (781 aa)
	ubac2	UBA domain containing 2. (322 aa)
	rhbdl3	Rhomboid-related protein 3; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family. (407 aa)
	rhbdd1	Rhomboid domain containing 1. (313 aa)
	tmem115	Transmembrane protein 115. (383 aa)
	rhbdd2	Rhomboid domain-containing protein. (322 aa)
	RHBDF2	Rhomboid 5 homolog 2. (832 aa)
	derl2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
	derl1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (254 aa)
	rhbdl1	Rhomboid-related protein 1; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family. (372 aa)
	PARL	Presenilin associated rhomboid like. (367 aa)
	LOC103382067	Rhomboid 5 homolog 1b (Drosophila). (927 aa)
	rhbdl2	Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family. (296 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PARL	rhbdd1	ENSCSEP00000024181	ENSCSEP00000009116	Presenilin associated rhomboid like.	Rhomboid domain containing 1.	0.459
PARL	rhbdd2	ENSCSEP00000024181	ENSCSEP00000012345	Presenilin associated rhomboid like.	Rhomboid domain-containing protein.	0.459
PARL	rhbdl1	ENSCSEP00000024181	ENSCSEP00000018745	Presenilin associated rhomboid like.	Rhomboid-related protein 1; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	0.438
PARL	rhbdl2	ENSCSEP00000024181	ENSCSEP00000031631	Presenilin associated rhomboid like.	Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	0.550
PARL	rhbdl3	ENSCSEP00000024181	ENSCSEP00000006195	Presenilin associated rhomboid like.	Rhomboid-related protein 3; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	0.483
PARL	tmem115	ENSCSEP00000024181	ENSCSEP00000009511	Presenilin associated rhomboid like.	Transmembrane protein 115.	0.436
PARL	ubac2	ENSCSEP00000024181	ENSCSEP00000004615	Presenilin associated rhomboid like.	UBA domain containing 2.	0.504
derl1	derl2	ENSCSEP00000017906	ENSCSEP00000014619	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.998
derl1	ubac2	ENSCSEP00000017906	ENSCSEP00000004615	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	UBA domain containing 2.	0.584
derl2	derl1	ENSCSEP00000014619	ENSCSEP00000017906	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.998
rhbdd1	PARL	ENSCSEP00000009116	ENSCSEP00000024181	Rhomboid domain containing 1.	Presenilin associated rhomboid like.	0.459
rhbdd2	PARL	ENSCSEP00000012345	ENSCSEP00000024181	Rhomboid domain-containing protein.	Presenilin associated rhomboid like.	0.459
rhbdd2	ubac2	ENSCSEP00000012345	ENSCSEP00000004615	Rhomboid domain-containing protein.	UBA domain containing 2.	0.513
rhbdl1	PARL	ENSCSEP00000018745	ENSCSEP00000024181	Rhomboid-related protein 1; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	Presenilin associated rhomboid like.	0.438
rhbdl2	PARL	ENSCSEP00000031631	ENSCSEP00000024181	Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	Presenilin associated rhomboid like.	0.550
rhbdl3	PARL	ENSCSEP00000006195	ENSCSEP00000024181	Rhomboid-related protein 3; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	Presenilin associated rhomboid like.	0.483
rhbdl3	ubac2	ENSCSEP00000006195	ENSCSEP00000004615	Rhomboid-related protein 3; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.	UBA domain containing 2.	0.457
tmem115	PARL	ENSCSEP00000009511	ENSCSEP00000024181	Transmembrane protein 115.	Presenilin associated rhomboid like.	0.436
tmem115	ubac2	ENSCSEP00000009511	ENSCSEP00000004615	Transmembrane protein 115.	UBA domain containing 2.	0.426
ubac2	PARL	ENSCSEP00000004615	ENSCSEP00000024181	UBA domain containing 2.	Presenilin associated rhomboid like.	0.504