34 items (Cynoglossus semilaevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (461 aa)
	ncbp2	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (189 aa)
	polr2h	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (155 aa)
	polr2j	Polymerase (RNA) II (DNA directed) polypeptide J. (117 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (327 aa)
	ctdp1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (991 aa)
	gtf2f1	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (533 aa)
	LOC103392281	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (277 aa)
	NCBP1	Nuclear cap binding protein subunit 1. (822 aa)
	polr2g	Polymerase (RNA) II (DNA directed) polypeptide G-like. (190 aa)
	nelfe	Negative elongation factor complex member E. (340 aa)
	supt4h1	Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family. (117 aa)
	POLR2E	RNA polymerase II subunit E. (229 aa)
	polr2f	Polymerase (RNA) II (DNA directed) polypeptide F. (127 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (551 aa)
	polr2d	Polymerase (RNA) II (DNA directed) polypeptide D. (144 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	polr2b	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
	LOC103388393	Si:dkey-12j5.1. (418 aa)
	nelfa	Negative elongation factor complex member A. (591 aa)
	nelfcd	Negative elongation factor complex member C/D. (576 aa)
	polr2a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1965 aa)
	polr2i	Polymerase (RNA) II (DNA directed) polypeptide I. (287 aa)
	polr2l	Polymerase (RNA) II (DNA directed) polypeptide L. (67 aa)
	polr2c	Polymerase (RNA) II (DNA directed) polypeptide C. (275 aa)
	mnat1	MNAT1 component of CDK activating kinase. (311 aa)
	supt5h	Transcription elongation factor SPT5. (991 aa)
	LOC103397561	General transcription factor IIH subunit. (414 aa)
	cdk7	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (344 aa)
	gtf2f2	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (270 aa)
	ercc3	Excision repair cross-complementation group 3. (785 aa)
	ENSCSEP00000026853	Uncharacterized protein. (795 aa)
	polr2k	Polymerase (RNA) II (DNA directed) polypeptide K. (58 aa)
	nelfb	Negative elongation factor complex member B. (580 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSEP00000026853	LOC103392281	ENSCSEP00000026853	ENSCSEP00000020853	Uncharacterized protein.	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.	0.851
ENSCSEP00000026853	NCBP1	ENSCSEP00000026853	ENSCSEP00000019395	Uncharacterized protein.	Nuclear cap binding protein subunit 1.	0.718
ENSCSEP00000026853	POLR2E	ENSCSEP00000026853	ENSCSEP00000011072	Uncharacterized protein.	RNA polymerase II subunit E.	0.969
ENSCSEP00000026853	cdk7	ENSCSEP00000026853	ENSCSEP00000025765	Uncharacterized protein.	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily.	0.706
ENSCSEP00000026853	ctdp1	ENSCSEP00000026853	ENSCSEP00000021244	Uncharacterized protein.	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	0.848
ENSCSEP00000026853	ercc3	ENSCSEP00000026853	ENSCSEP00000025795	Uncharacterized protein.	Excision repair cross-complementation group 3.	0.652
ENSCSEP00000026853	gtf2f1	ENSCSEP00000026853	ENSCSEP00000020911	Uncharacterized protein.	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	0.731
ENSCSEP00000026853	gtf2f2	ENSCSEP00000026853	ENSCSEP00000025766	Uncharacterized protein.	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.	0.851
ENSCSEP00000026853	gtf2h1	ENSCSEP00000026853	ENSCSEP00000010037	Uncharacterized protein.	General transcription factor IIH, polypeptide 1.	0.802
ENSCSEP00000026853	gtf2h3	ENSCSEP00000026853	ENSCSEP00000023306	Uncharacterized protein.	General transcription factor IIH, polypeptide 3.	0.719
ENSCSEP00000026853	gtf2h4	ENSCSEP00000026853	ENSCSEP00000029297	Uncharacterized protein.	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.753
ENSCSEP00000026853	mnat1	ENSCSEP00000026853	ENSCSEP00000002272	Uncharacterized protein.	MNAT1 component of CDK activating kinase.	0.699
ENSCSEP00000026853	ncbp2	ENSCSEP00000026853	ENSCSEP00000030161	Uncharacterized protein.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.741
ENSCSEP00000026853	nelfa	ENSCSEP00000026853	ENSCSEP00000006417	Uncharacterized protein.	Negative elongation factor complex member A.	0.948
ENSCSEP00000026853	nelfb	ENSCSEP00000026853	ENSCSEP00000027425	Uncharacterized protein.	Negative elongation factor complex member B.	0.948
ENSCSEP00000026853	nelfcd	ENSCSEP00000026853	ENSCSEP00000006336	Uncharacterized protein.	Negative elongation factor complex member C/D.	0.906
ENSCSEP00000026853	nelfe	ENSCSEP00000026853	ENSCSEP00000017683	Uncharacterized protein.	Negative elongation factor complex member E.	0.895
ENSCSEP00000026853	polr2a	ENSCSEP00000026853	ENSCSEP00000004081	Uncharacterized protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.970
ENSCSEP00000026853	polr2b	ENSCSEP00000026853	ENSCSEP00000008316	Uncharacterized protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.973
ENSCSEP00000026853	polr2c	ENSCSEP00000026853	ENSCSEP00000002623	Uncharacterized protein.	Polymerase (RNA) II (DNA directed) polypeptide C.	0.969