91 items (Cynoglossus semilaevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103379359	Epithelial splicing regulatory protein 2. (738 aa)
	tia1	Uncharacterized protein. (405 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
	Spry2	Sprouty RTK signaling antagonist 2. (418 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	ENSCSEP00000012109	Metallophos domain-containing protein. (79 aa)
	MAPK1	Mitogen-activated protein kinase 1. (172 aa)
	LOC103385130	Heterogeneous nuclear ribonucleoprotein A1a. (350 aa)
	ENSCSEP00000011448	PI3K-ABD domain-containing protein; Belongs to the PI3/PI4-kinase family. (123 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1276 aa)
	POLR2E	RNA polymerase II subunit E. (229 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (248 aa)
	PTBP2	Polypyrimidine tract binding protein 2a. (518 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (265 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (185 aa)
	polr2f	Polymerase (RNA) II (DNA directed) polypeptide F. (127 aa)
	LOC103390897	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (211 aa)
	polr2d	Polymerase (RNA) II (DNA directed) polypeptide D. (144 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	polr2b	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
	ptbp1	Polypyrimidine tract binding protein 1a. (541 aa)
	LOC103390704	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC103390679	Fibroblast growth factor binding protein 1b. (201 aa)
	fgfbp3	Uncharacterized protein. (199 aa)
	Fgfbp2	Fibroblast growth factor binding protein 2b. (270 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1205 aa)
	LOC103399916	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
	polr2a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1965 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (917 aa)
	polr2i	Polymerase (RNA) II (DNA directed) polypeptide I. (287 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (731 aa)
	polr2l	Polymerase (RNA) II (DNA directed) polypeptide L. (67 aa)
	polr2c	Polymerase (RNA) II (DNA directed) polypeptide C. (275 aa)
	esrp1	Epithelial splicing regulatory protein 1. (688 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	LOC103385760	Fibroblast growth factor receptor substrate 3. (616 aa)
	PTBP3	Polypyrimidine tract binding protein 3. (492 aa)
	ENSCSEP00000032733	Uncharacterized protein. (132 aa)
	PLCG1	Phosphoinositide phospholipase C. (474 aa)
	gab1	GRB2-associated binding protein 1. (835 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (278 aa)
	ENSCSEP00000033458	Fibroblast growth factor receptor substrate 2b. (492 aa)
	LOC103393219	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (405 aa)
	LOC103389109	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (359 aa)
	LOC103391367	Fibroblast growth factor receptor 2. (661 aa)
	LOC103396554	Uncharacterized protein. (523 aa)
	LOC103378498	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	LOC103397828	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
	ncbp2	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (189 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC103386740	Tyrosine-protein kinase. (558 aa)
	mknk1	MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (464 aa)
	LOC103397742	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
	polr2j	Polymerase (RNA) II (DNA directed) polypeptide J. (117 aa)
	polr2k	Polymerase (RNA) II (DNA directed) polypeptide K. (58 aa)
	LOC103391274	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (393 aa)
	LOC103396148	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
	fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	mknk2	MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa)
	LOC103395395	Uncharacterized protein. (869 aa)
	gtf2f2	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (270 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (952 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (151 aa)
	UBB	Ubiquitin B. (744 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
	LOC103391208	Serine/threonine-protein phosphatase. (309 aa)
	polr2h	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (155 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	LOC103391194	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (156 aa)
	ENSCSEP00000023759	Ubiquitin-like domain-containing protein. (92 aa)
	cblc	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (550 aa)
	hnrnpm	Heterogeneous nuclear ribonucleoprotein M. (690 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	LOC103385228	Tyrosine-protein kinase. (551 aa)
	grb2	Growth factor receptor-bound protein 2b. (220 aa)
	LOC103390060	Cytotoxic granule-associated RNA binding protein 1, like. (385 aa)
	LOC103397209	Uncharacterized protein. (387 aa)
	LOC103392975	Zgc:55558. (187 aa)
	gtf2f1	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (533 aa)
	LOC103392281	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (277 aa)
	Shc4	Uncharacterized protein. (342 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
	LOC103384120	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
	LOC103387590	Uncharacterized protein. (271 aa)
	NCBP1	Nuclear cap binding protein subunit 1. (822 aa)
	LOC103395214	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (149 aa)
	polr2g	Polymerase (RNA) II (DNA directed) polypeptide G-like. (190 aa)
	tial1	TIA1 cytotoxic granule-associated RNA binding protein-like 1. (384 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ENSCSEP00000011448	ENSCSEP00000004032	ENSCSEP00000011448	Cold shock domain containing E1, RNA-binding.	PI3K-ABD domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.525
CSDE1	ENSCSEP00000023759	ENSCSEP00000004032	ENSCSEP00000023759	Cold shock domain containing E1, RNA-binding.	Ubiquitin-like domain-containing protein.	0.454
CSDE1	ENSCSEP00000033458	ENSCSEP00000004032	ENSCSEP00000033458	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2b.	0.438
CSDE1	LOC103378498	ENSCSEP00000004032	ENSCSEP00000028334	Cold shock domain containing E1, RNA-binding.	Protein phosphatase 2, regulatory subunit A, beta b.	0.447
CSDE1	LOC103385760	ENSCSEP00000004032	ENSCSEP00000002178	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 3.	0.438
CSDE1	LOC103390704	ENSCSEP00000004032	ENSCSEP00000007011	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.469
CSDE1	LOC103390897	ENSCSEP00000004032	ENSCSEP00000009982	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.469
CSDE1	LOC103391194	ENSCSEP00000004032	ENSCSEP00000023803	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.412
CSDE1	LOC103393219	ENSCSEP00000004032	ENSCSEP00000027614	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.425
CSDE1	LOC103395214	ENSCSEP00000004032	ENSCSEP00000018906	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.412
CSDE1	LOC103396148	ENSCSEP00000004032	ENSCSEP00000026590	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.525
CSDE1	LOC103397828	ENSCSEP00000004032	ENSCSEP00000029876	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.425
CSDE1	MAPK1	ENSCSEP00000004032	ENSCSEP00000011950	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase 1.	0.425
CSDE1	PIK3CA	ENSCSEP00000004032	ENSCSEP00000030420	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.525
CSDE1	Shc4	ENSCSEP00000004032	ENSCSEP00000020040	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.432
CSDE1	UBB	ENSCSEP00000004032	ENSCSEP00000025180	Cold shock domain containing E1, RNA-binding.	Ubiquitin B.	0.539
CSDE1	fgf23	ENSCSEP00000004032	ENSCSEP00000010801	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.450
CSDE1	fgf3	ENSCSEP00000004032	ENSCSEP00000010968	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.479
CSDE1	fgf4	ENSCSEP00000004032	ENSCSEP00000010997	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.492
CSDE1	fgf5	ENSCSEP00000004032	ENSCSEP00000024357	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.429