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| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (419 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (358 aa) |
| | tdrd3 | Tudor domain containing 3. (773 aa) |
| | abraxas1 | Abraxas 1, BRCA1 A complex subunit. (346 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (596 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (436 aa) |
| | Polh | Polymerase (DNA directed), eta. (294 aa) |
| | rps27a | Ribosomal protein S27a. (156 aa) |
| | Atm | Non-specific serine/threonine protein kinase. (3052 aa) |
| | palb2 | PALB2_WD40 domain-containing protein. (1240 aa) |
| | Parp3 | Poly [ADP-ribose] polymerase. (514 aa) |
| | babam2 | BRISC and BRCA1 A complex member 2. (386 aa) |
| | eme1 | Essential meiotic structure-specific endonuclease 1. (532 aa) |
| | LOC103383557 | Small ubiquitin-related modifier. (96 aa) |
| | LOC103378402 | Small ubiquitin-related modifier. (94 aa) |
| | ENSCSEP00000005051 | Histone H2B; Belongs to the histone H2B family. (112 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2429 aa) |
| | ENSCSEP00000006274 | Histone H2B; Belongs to the histone H2B family. (114 aa) |
| | ENSCSEP00000006303 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa) |
| | ENSCSEP00000006355 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (147 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | timeless | Timeless circadian clock. (1198 aa) |
| | ccna2 | Cyclin A2; Belongs to the cyclin family. (447 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa) |
| | RCBTB1 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (637 aa) |
| | rfc1 | Replication factor C subunit 1. (1083 aa) |
| | Polq | Polymerase (DNA directed), theta. (2755 aa) |
| | cdca7 | Cell division cycle associated 7a. (401 aa) |
| | pias4 | Protein inhibitor of activated STAT, 4a. (499 aa) |
| | LOC103380153 | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (384 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (149 aa) |
| | Rnf169 | Ring finger protein 169. (665 aa) |
| | kxd1 | KxDL motif containing 1. (180 aa) |
| | Rad52 | Uncharacterized protein. (99 aa) |
| | LOC103393291 | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa) |
| | ENSCSEP00000009964 | Uncharacterized protein. (85 aa) |
| | ENSCSEP00000010388 | Histone H2B; Belongs to the histone H2B family. (122 aa) |
| | Pold2 | Uncharacterized protein. (78 aa) |
| | ENSCSEP00000010689 | Histone H2B; Belongs to the histone H2B family. (114 aa) |
| | ENSCSEP00000010737 | Histone H2B; Belongs to the histone H2B family. (117 aa) |
| | rad51ap1 | RAD51 associated protein 1. (316 aa) |
| | rcbtb2 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (554 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (394 aa) |
| | brca1 | Uncharacterized protein. (1217 aa) |
| | ENSCSEP00000011692 | Ubiquitin-like domain-containing protein. (102 aa) |
| | ENSCSEP00000011696 | Uncharacterized protein. (103 aa) |
| | rhno1 | Si:ch73-352p4.5. (301 aa) |
| | ppp4r2 | Protein phosphatase 4, regulatory subunit 2b. (443 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (373 aa) |
| | ENSCSEP00000012570 | Histone H2A; Belongs to the histone H2A family. (218 aa) |
| | sirt7 | Sirtuin 7. (408 aa) |
| | ENSCSEP00000012655 | DNA_pol_D_N domain-containing protein. (396 aa) |
| | cdca7l | Cell division cycle associated 7b. (416 aa) |
| | Rnf168 | RING-type domain-containing protein. (117 aa) |
| | ENSCSEP00000014019 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (89 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (640 aa) |
| | ENSCSEP00000014113 | Histone domain-containing protein; Belongs to the histone H2B family. (109 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (728 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1101 aa) |
| | LOC103382819 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa) |
| | atrip | Uncharacterized protein. (600 aa) |
| | chek1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (488 aa) |
| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2. (158 aa) |
| | spidr | Uncharacterized protein. (921 aa) |
| | Rad9b | Uncharacterized protein. (177 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (519 aa) |
| | LOC103396322 | Histone H2B; Belongs to the histone H2B family. (116 aa) |
| | ENSCSEP00000017327 | Uncharacterized protein. (1079 aa) |
| | LOC103392195 | Small ubiquitin-related modifier. (100 aa) |
| | rbbp8 | CtIP_N domain-containing protein. (539 aa) |
| | ENSCSEP00000018191 | SAE2 domain-containing protein. (90 aa) |
| | ENSCSEP00000018388 | Uncharacterized protein. (232 aa) |
| | Polk | Polymerase (DNA directed) kappa. (867 aa) |
| | ube2i | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | ENSCSEP00000019257 | X-ray repair complementing defective repair in Chinese hamster cells 1. (567 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (642 aa) |
| | sumo2 | Ubiquitin-like domain-containing protein. (149 aa) |
| | LOC103395242 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (633 aa) |
| | ENSCSEP00000020203 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (315 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa) |
| | blm | BLM RecQ like helicase. (1300 aa) |
| | Whsc1 | Nuclear receptor binding SET domain protein 2. (931 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (311 aa) |
| | pold1 | DNA polymerase. (1077 aa) |
| | sirt6 | Sirtuin 6. (351 aa) |
| | dna2 | DNA replication helicase/nuclease 2. (1185 aa) |
| | slf1 | Uncharacterized protein. (788 aa) |
| | LOC103391605 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (281 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (540 aa) |
| | rad51d | RAD51 paralog D. (383 aa) |
| | ENSCSEP00000023029 | Histone H2B; Belongs to the histone H2B family. (113 aa) |
| | lig3 | DNA ligase. (1015 aa) |
| | ENSCSEP00000023037 | annotation not available (67 aa) |
| | HIST1H4J | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
| | ENSCSEP00000023079 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
| | ENSCSEP00000023097 | Histone H2B; Belongs to the histone H2B family. (114 aa) |
| | ENSCSEP00000023236 | RecQ helicase-like 4. (807 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1319 aa) |
| | ENSCSEP00000023759 | Ubiquitin-like domain-containing protein. (92 aa) |
| | pold4 | Si:dkey-28b4.7. (109 aa) |
| | ENSCSEP00000025093 | Uncharacterized protein. (194 aa) |
| | UBB | Ubiquitin B. (744 aa) |
| | uba52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (151 aa) |
| | abl1 | Tyrosine-protein kinase. (1113 aa) |
| | ENSCSEP00000025964 | XPGN domain-containing protein. (140 aa) |
| | exo1 | Exonuclease 1. (597 aa) |
| | babam1 | BRISC and BRCA1 A complex member 1. (316 aa) |
| | LOC103389086 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (144 aa) |
| | ankrd12 | Ankyrin repeat domain 12. (1932 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (718 aa) |
| | rad51c | RAD51 paralog C. (330 aa) |
| | brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (236 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa) |
| | ENSCSEP00000027438 | Zgc:110269. (389 aa) |
| | ENSCSEP00000027441 | Uncharacterized protein. (202 aa) |
| | ENSCSEP00000027456 | Uncharacterized protein. (660 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1996 aa) |
| | ENSCSEP00000027862 | Ankyrin repeat domain 11. (2775 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (281 aa) |
| | oard1 | Uncharacterized protein. (404 aa) |
| | xrcc2 | RECA_2 domain-containing protein. (324 aa) |
| | rpa2 | Replication protein A2. (274 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (355 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1517 aa) |
| | rad1 | RAD1 homolog (S. pombe). (277 aa) |
| | ENSCSEP00000031260 | Uncharacterized protein; Belongs to the histone H2B family. (112 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (130 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (338 aa) |
| | rmi2 | RecQ mediated genome instability 2. (163 aa) |
| | parp2 | Poly [ADP-ribose] polymerase. (653 aa) |
| | LOC103385609 | Ubiquitin-conjugating enzyme E2 variant 1. (147 aa) |
