STRINGSTRING
pold3 pold3 rfc4 rfc4 tdrd3 tdrd3 abraxas1 abraxas1 mus81 mus81 meiob meiob Polh Polh rps27a rps27a Atm Atm palb2 palb2 Parp3 Parp3 babam2 babam2 eme1 eme1 LOC103383557 LOC103383557 LOC103378402 LOC103378402 ENSCSEP00000005051 ENSCSEP00000005051 atr atr ENSCSEP00000006274 ENSCSEP00000006274 ENSCSEP00000006303 ENSCSEP00000006303 ENSCSEP00000006355 ENSCSEP00000006355 cdk2 cdk2 timeless timeless ccna2 ccna2 pole2 pole2 RCBTB1 RCBTB1 rfc1 rfc1 Polq Polq cdca7 cdca7 pias4 pias4 LOC103380153 LOC103380153 xrcc3 xrcc3 pole3 pole3 Rnf169 Rnf169 kxd1 kxd1 Rad52 Rad52 LOC103393291 LOC103393291 top3a top3a ENSCSEP00000009964 ENSCSEP00000009964 ENSCSEP00000010388 ENSCSEP00000010388 Pold2 Pold2 ENSCSEP00000010689 ENSCSEP00000010689 ENSCSEP00000010737 ENSCSEP00000010737 rad51ap1 rad51ap1 rcbtb2 rcbtb2 rad9a rad9a brca1 brca1 ENSCSEP00000011692 ENSCSEP00000011692 ENSCSEP00000011696 ENSCSEP00000011696 rhno1 rhno1 ppp4r2 ppp4r2 tipin tipin ENSCSEP00000012570 ENSCSEP00000012570 sirt7 sirt7 ENSCSEP00000012655 ENSCSEP00000012655 cdca7l cdca7l Rnf168 Rnf168 ENSCSEP00000014019 ENSCSEP00000014019 rad17 rad17 ENSCSEP00000014113 ENSCSEP00000014113 fen1 fen1 exd2 exd2 tp53bp1 tp53bp1 LOC103382819 LOC103382819 atrip atrip chek1 chek1 ube2v2 ube2v2 spidr spidr Rad9b Rad9b pold2 pold2 LOC103396322 LOC103396322 ENSCSEP00000017327 ENSCSEP00000017327 LOC103392195 LOC103392195 rbbp8 rbbp8 ENSCSEP00000018191 ENSCSEP00000018191 ENSCSEP00000018388 ENSCSEP00000018388 Polk Polk ube2i ube2i ENSCSEP00000019257 ENSCSEP00000019257 rfc3 rfc3 rmi1 rmi1 sumo2 sumo2 LOC103395242 LOC103395242 ENSCSEP00000020203 ENSCSEP00000020203 rpa1 rpa1 blm blm Whsc1 Whsc1 ppp4c ppp4c pold1 pold1 sirt6 sirt6 dna2 dna2 slf1 slf1 LOC103391605 LOC103391605 kat5 kat5 rad51d rad51d ENSCSEP00000023029 ENSCSEP00000023029 lig3 lig3 ENSCSEP00000023037 ENSCSEP00000023037 HIST1H4J HIST1H4J ENSCSEP00000023079 ENSCSEP00000023079 ENSCSEP00000023097 ENSCSEP00000023097 ENSCSEP00000023236 ENSCSEP00000023236 rad50 rad50 ENSCSEP00000023759 ENSCSEP00000023759 pold4 pold4 ENSCSEP00000025093 ENSCSEP00000025093 UBB UBB uba52 uba52 abl1 abl1 ENSCSEP00000025964 ENSCSEP00000025964 exo1 exo1 babam1 babam1 LOC103389086 LOC103389086 ankrd12 ankrd12 mre11 mre11 rad51c rad51c brcc3 brcc3 rad51 rad51 ENSCSEP00000027438 ENSCSEP00000027438 ENSCSEP00000027441 ENSCSEP00000027441 ENSCSEP00000027456 ENSCSEP00000027456 POLE POLE ENSCSEP00000027862 ENSCSEP00000027862 hus1 hus1 oard1 oard1 xrcc2 xrcc2 rpa2 rpa2 rfc2 rfc2 pcna pcna topbp1 topbp1 rad1 rad1 ENSCSEP00000031260 ENSCSEP00000031260 pole4 pole4 parp1 parp1 rnf8 rnf8 rfc5 rfc5 rmi2 rmi2 parp2 parp2 LOC103385609 LOC103385609
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (419 aa)
rfc4Replication factor C (activator 1) 4. (358 aa)
tdrd3Tudor domain containing 3. (773 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (346 aa)
mus81MUS81 structure-specific endonuclease subunit. (596 aa)
meiobMethionine sulfoxide reductase B1b. (436 aa)
PolhPolymerase (DNA directed), eta. (294 aa)
rps27aRibosomal protein S27a. (156 aa)
AtmNon-specific serine/threonine protein kinase. (3052 aa)
palb2PALB2_WD40 domain-containing protein. (1240 aa)
Parp3Poly [ADP-ribose] polymerase. (514 aa)
babam2BRISC and BRCA1 A complex member 2. (386 aa)
eme1Essential meiotic structure-specific endonuclease 1. (532 aa)
LOC103383557Small ubiquitin-related modifier. (96 aa)
LOC103378402Small ubiquitin-related modifier. (94 aa)
ENSCSEP00000005051Histone H2B; Belongs to the histone H2B family. (112 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2429 aa)
ENSCSEP00000006274Histone H2B; Belongs to the histone H2B family. (114 aa)
ENSCSEP00000006303Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
ENSCSEP00000006355Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (147 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
timelessTimeless circadian clock. (1198 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (447 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
RCBTB1Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (637 aa)
rfc1Replication factor C subunit 1. (1083 aa)
PolqPolymerase (DNA directed), theta. (2755 aa)
cdca7Cell division cycle associated 7a. (401 aa)
pias4Protein inhibitor of activated STAT, 4a. (499 aa)
LOC103380153Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (384 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (149 aa)
Rnf169Ring finger protein 169. (665 aa)
kxd1KxDL motif containing 1. (180 aa)
Rad52Uncharacterized protein. (99 aa)
LOC103393291Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa)
ENSCSEP00000009964Uncharacterized protein. (85 aa)
ENSCSEP00000010388Histone H2B; Belongs to the histone H2B family. (122 aa)
Pold2Uncharacterized protein. (78 aa)
ENSCSEP00000010689Histone H2B; Belongs to the histone H2B family. (114 aa)
ENSCSEP00000010737Histone H2B; Belongs to the histone H2B family. (117 aa)
rad51ap1RAD51 associated protein 1. (316 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (554 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (394 aa)
brca1Uncharacterized protein. (1217 aa)
ENSCSEP00000011692Ubiquitin-like domain-containing protein. (102 aa)
ENSCSEP00000011696Uncharacterized protein. (103 aa)
rhno1Si:ch73-352p4.5. (301 aa)
ppp4r2Protein phosphatase 4, regulatory subunit 2b. (443 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (373 aa)
ENSCSEP00000012570Histone H2A; Belongs to the histone H2A family. (218 aa)
sirt7Sirtuin 7. (408 aa)
ENSCSEP00000012655DNA_pol_D_N domain-containing protein. (396 aa)
cdca7lCell division cycle associated 7b. (416 aa)
Rnf168RING-type domain-containing protein. (117 aa)
ENSCSEP00000014019Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (89 aa)
rad17RAD17 checkpoint clamp loader component. (640 aa)
ENSCSEP00000014113Histone domain-containing protein; Belongs to the histone H2B family. (109 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
exd2Exonuclease 3'-5' domain containing 2. (728 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1101 aa)
LOC103382819UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
atripUncharacterized protein. (600 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (488 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (158 aa)
spidrUncharacterized protein. (921 aa)
Rad9bUncharacterized protein. (177 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (519 aa)
LOC103396322Histone H2B; Belongs to the histone H2B family. (116 aa)
ENSCSEP00000017327Uncharacterized protein. (1079 aa)
LOC103392195Small ubiquitin-related modifier. (100 aa)
rbbp8CtIP_N domain-containing protein. (539 aa)
ENSCSEP00000018191SAE2 domain-containing protein. (90 aa)
ENSCSEP00000018388Uncharacterized protein. (232 aa)
PolkPolymerase (DNA directed) kappa. (867 aa)
ube2iUbiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
ENSCSEP00000019257X-ray repair complementing defective repair in Chinese hamster cells 1. (567 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (642 aa)
sumo2Ubiquitin-like domain-containing protein. (149 aa)
LOC103395242Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (633 aa)
ENSCSEP00000020203DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (315 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
blmBLM RecQ like helicase. (1300 aa)
Whsc1Nuclear receptor binding SET domain protein 2. (931 aa)
ppp4cSerine/threonine-protein phosphatase. (311 aa)
pold1DNA polymerase. (1077 aa)
sirt6Sirtuin 6. (351 aa)
dna2DNA replication helicase/nuclease 2. (1185 aa)
slf1Uncharacterized protein. (788 aa)
LOC103391605Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (281 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (540 aa)
rad51dRAD51 paralog D. (383 aa)
ENSCSEP00000023029Histone H2B; Belongs to the histone H2B family. (113 aa)
lig3DNA ligase. (1015 aa)
ENSCSEP00000023037annotation not available (67 aa)
HIST1H4JHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSCSEP00000023079Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSCSEP00000023097Histone H2B; Belongs to the histone H2B family. (114 aa)
ENSCSEP00000023236RecQ helicase-like 4. (807 aa)
rad50RAD50 homolog, double strand break repair protein. (1319 aa)
ENSCSEP00000023759Ubiquitin-like domain-containing protein. (92 aa)
pold4Si:dkey-28b4.7. (109 aa)
ENSCSEP00000025093Uncharacterized protein. (194 aa)
UBBUbiquitin B. (744 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (151 aa)
abl1Tyrosine-protein kinase. (1113 aa)
ENSCSEP00000025964XPGN domain-containing protein. (140 aa)
exo1Exonuclease 1. (597 aa)
babam1BRISC and BRCA1 A complex member 1. (316 aa)
LOC103389086UBIQUITIN_CONJUGAT_2 domain-containing protein. (144 aa)
ankrd12Ankyrin repeat domain 12. (1932 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (718 aa)
rad51cRAD51 paralog C. (330 aa)
brcc3BRCA1/BRCA2-containing complex, subunit 3. (236 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
ENSCSEP00000027438Zgc:110269. (389 aa)
ENSCSEP00000027441Uncharacterized protein. (202 aa)
ENSCSEP00000027456Uncharacterized protein. (660 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1996 aa)
ENSCSEP00000027862Ankyrin repeat domain 11. (2775 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (281 aa)
oard1Uncharacterized protein. (404 aa)
xrcc2RECA_2 domain-containing protein. (324 aa)
rpa2Replication protein A2. (274 aa)
rfc2Replication factor C (activator 1) 2. (355 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
topbp1DNA topoisomerase II binding protein 1. (1517 aa)
rad1RAD1 homolog (S. pombe). (277 aa)
ENSCSEP00000031260Uncharacterized protein; Belongs to the histone H2B family. (112 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (130 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa)
rfc5Replication factor C (activator 1) 5. (338 aa)
rmi2RecQ mediated genome instability 2. (163 aa)
parp2Poly [ADP-ribose] polymerase. (653 aa)
LOC103385609Ubiquitin-conjugating enzyme E2 variant 1. (147 aa)
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
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