STRINGSTRING
ankrd12 ankrd12 mre11 mre11 tdp2 tdp2 ENSCSEP00000027862 ENSCSEP00000027862 LOC103391326 LOC103391326 ENSCSEP00000031260 ENSCSEP00000031260 xrcc6 xrcc6 rnf8 rnf8 paxip1 paxip1 LOC103385609 LOC103385609 ENSCSEP00000012570 ENSCSEP00000012570 Rnf168 Rnf168 polm polm dntt dntt Mdc1 Mdc1 LOC103382819 LOC103382819 ube2v2 ube2v2 tdp1 tdp1 cnppd1 cnppd1 xrcc5 xrcc5 LOC103396322 LOC103396322 Xrcc4 Xrcc4 ENSCSEP00000020864 ENSCSEP00000020864 Whsc1 Whsc1 Lig4 Lig4 kat5 kat5 ENSCSEP00000023029 ENSCSEP00000023029 ENSCSEP00000023037 ENSCSEP00000023037 HIST1H4J HIST1H4J ENSCSEP00000023079 ENSCSEP00000023079 ENSCSEP00000023097 ENSCSEP00000023097 rad50 rad50 ENSCSEP00000025093 ENSCSEP00000025093 LOC103389086 LOC103389086 ENSCSEP00000005051 ENSCSEP00000005051 Rif1 Rif1 ENSCSEP00000006274 ENSCSEP00000006274 ENSCSEP00000006303 ENSCSEP00000006303 brca1 brca1 tmem182 tmem182 pias4 pias4 LOC103380153 LOC103380153 Rnf169 Rnf169 ENSCSEP00000010388 ENSCSEP00000010388 ENSCSEP00000010689 ENSCSEP00000010689 ENSCSEP00000010737 ENSCSEP00000010737 ENSCSEP00000006355 ENSCSEP00000006355 dclre1c dclre1c ENSCSEP00000014019 ENSCSEP00000014019 ENSCSEP00000014113 ENSCSEP00000014113 tp53bp1 tp53bp1 Atm Atm
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ankrd12Ankyrin repeat domain 12. (1932 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (718 aa)
tdp2Tyrosyl-DNA phosphodiesterase 2b. (360 aa)
ENSCSEP00000027862Ankyrin repeat domain 11. (2775 aa)
LOC103391326Uncharacterized protein. (259 aa)
ENSCSEP00000031260Uncharacterized protein; Belongs to the histone H2B family. (112 aa)
xrcc6X-ray repair complementing defective repair in Chinese hamster cells 6. (623 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa)
paxip1PAX interacting (with transcription-activation domain) protein 1. (1070 aa)
LOC103385609Ubiquitin-conjugating enzyme E2 variant 1. (147 aa)
ENSCSEP00000012570Histone H2A; Belongs to the histone H2A family. (218 aa)
Rnf168RING-type domain-containing protein. (117 aa)
polmDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (531 aa)
dnttDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (490 aa)
Mdc1FHA domain-containing protein. (236 aa)
LOC103382819UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (158 aa)
tdp1Tyrosyl-DNA phosphodiesterase 1. (569 aa)
cnppd1Cyclin Pas1/PHO80 domain containing 1. (442 aa)
xrcc5X-ray repair complementing defective repair in Chinese hamster cells 5. (736 aa)
LOC103396322Histone H2B; Belongs to the histone H2B family. (116 aa)
Xrcc4Uncharacterized protein. (164 aa)
ENSCSEP00000020864Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3778 aa)
Whsc1Nuclear receptor binding SET domain protein 2. (931 aa)
Lig4DNA ligase. (922 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (540 aa)
ENSCSEP00000023029Histone H2B; Belongs to the histone H2B family. (113 aa)
ENSCSEP00000023037annotation not available (67 aa)
HIST1H4JHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSCSEP00000023079Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSCSEP00000023097Histone H2B; Belongs to the histone H2B family. (114 aa)
rad50RAD50 homolog, double strand break repair protein. (1319 aa)
ENSCSEP00000025093Uncharacterized protein. (194 aa)
LOC103389086UBIQUITIN_CONJUGAT_2 domain-containing protein. (144 aa)
ENSCSEP00000005051Histone H2B; Belongs to the histone H2B family. (112 aa)
Rif1Replication timing regulatory factor 1. (2288 aa)
ENSCSEP00000006274Histone H2B; Belongs to the histone H2B family. (114 aa)
ENSCSEP00000006303Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
brca1Uncharacterized protein. (1217 aa)
tmem182Transmembrane protein 182a. (249 aa)
pias4Protein inhibitor of activated STAT, 4a. (499 aa)
LOC103380153Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
Rnf169Ring finger protein 169. (665 aa)
ENSCSEP00000010388Histone H2B; Belongs to the histone H2B family. (122 aa)
ENSCSEP00000010689Histone H2B; Belongs to the histone H2B family. (114 aa)
ENSCSEP00000010737Histone H2B; Belongs to the histone H2B family. (117 aa)
ENSCSEP00000006355Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (147 aa)
dclre1cDNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (534 aa)
ENSCSEP00000014019Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (89 aa)
ENSCSEP00000014113Histone domain-containing protein; Belongs to the histone H2B family. (109 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1101 aa)
AtmNon-specific serine/threonine protein kinase. (3052 aa)
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
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