32 items (Cynoglossus semilaevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rfc2	Replication factor C (activator 1) 2. (355 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (419 aa)
	rfc5	Replication factor C (activator 1) 5. (338 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (130 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	rpa2	Replication protein A2. (274 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1996 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (151 aa)
	UBB	Ubiquitin B. (744 aa)
	pold4	Si:dkey-28b4.7. (109 aa)
	ENSCSEP00000023759	Ubiquitin-like domain-containing protein. (92 aa)
	pold1	DNA polymerase. (1077 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	ENSCSEP00000020203	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (315 aa)
	ENSCSEP00000020096	Uncharacterized protein. (707 aa)
	LOC103395242	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (633 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	Polk	Polymerase (DNA directed) kappa. (867 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (519 aa)
	ENSCSEP00000012655	DNA_pol_D_N domain-containing protein. (396 aa)
	ENSCSEP00000011696	Uncharacterized protein. (103 aa)
	rcbtb2	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (554 aa)
	Pold2	Uncharacterized protein. (78 aa)
	ENSCSEP00000009964	Uncharacterized protein. (85 aa)
	kxd1	KxDL motif containing 1. (180 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (149 aa)
	rfc1	Replication factor C subunit 1. (1083 aa)
	RCBTB1	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (637 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	meiob	Methionine sulfoxide reductase B1b. (436 aa)
	rfc4	Replication factor C (activator 1) 4. (358 aa)

Your Current Organism:

Cynoglossus semilaevis

NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCSEP00000009964	ENSCSEP00000011696	ENSCSEP00000009964	ENSCSEP00000011696	Uncharacterized protein.	Uncharacterized protein.	0.734
ENSCSEP00000009964	ENSCSEP00000012655	ENSCSEP00000009964	ENSCSEP00000012655	Uncharacterized protein.	DNA_pol_D_N domain-containing protein.	0.626
ENSCSEP00000009964	ENSCSEP00000020096	ENSCSEP00000009964	ENSCSEP00000020096	Uncharacterized protein.	Uncharacterized protein.	0.647
ENSCSEP00000009964	ENSCSEP00000020203	ENSCSEP00000009964	ENSCSEP00000020203	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.720
ENSCSEP00000009964	LOC103395242	ENSCSEP00000009964	ENSCSEP00000019947	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.973
ENSCSEP00000009964	POLE	ENSCSEP00000009964	ENSCSEP00000027709	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.720
ENSCSEP00000009964	Pold2	ENSCSEP00000009964	ENSCSEP00000010635	Uncharacterized protein.	Uncharacterized protein.	0.626
ENSCSEP00000009964	Polk	ENSCSEP00000009964	ENSCSEP00000018474	Uncharacterized protein.	Polymerase (DNA directed) kappa.	0.618
ENSCSEP00000009964	UBB	ENSCSEP00000009964	ENSCSEP00000025180	Uncharacterized protein.	Ubiquitin B.	0.653
ENSCSEP00000009964	meiob	ENSCSEP00000009964	ENSCSEP00000001347	Uncharacterized protein.	Methionine sulfoxide reductase B1b.	0.962
ENSCSEP00000009964	pcna	ENSCSEP00000009964	ENSCSEP00000030429	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.728
ENSCSEP00000009964	pold1	ENSCSEP00000009964	ENSCSEP00000021597	Uncharacterized protein.	DNA polymerase.	0.793
ENSCSEP00000009964	pold2	ENSCSEP00000009964	ENSCSEP00000016634	Uncharacterized protein.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.626
ENSCSEP00000009964	pole2	ENSCSEP00000009964	ENSCSEP00000007344	Uncharacterized protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.722
ENSCSEP00000009964	pole3	ENSCSEP00000009964	ENSCSEP00000009339	Uncharacterized protein.	Polymerase (DNA directed), epsilon 3 (p17 subunit).	0.689
ENSCSEP00000009964	pole4	ENSCSEP00000009964	ENSCSEP00000031533	Uncharacterized protein.	Polymerase (DNA-directed), epsilon 4, accessory subunit.	0.723
ENSCSEP00000009964	rfc1	ENSCSEP00000009964	ENSCSEP00000007615	Uncharacterized protein.	Replication factor C subunit 1.	0.692
ENSCSEP00000009964	rfc2	ENSCSEP00000009964	ENSCSEP00000029824	Uncharacterized protein.	Replication factor C (activator 1) 2.	0.832
ENSCSEP00000009964	rfc3	ENSCSEP00000009964	ENSCSEP00000019462	Uncharacterized protein.	Replication factor C (activator 1) 3.	0.752
ENSCSEP00000009964	rfc4	ENSCSEP00000009964	ENSCSEP00000000657	Uncharacterized protein.	Replication factor C (activator 1) 4.	0.882