STRINGSTRING
rfc4 rfc4 bicra bicra LOC103394542 LOC103394542 LOC103389639 LOC103389639 LOC103399400 LOC103399400 ENSCSEP00000011696 ENSCSEP00000011696 gins4 gins4 psmd3 psmd3 ENSCSEP00000012655 ENSCSEP00000012655 cdc27 cdc27 Cdc27 Cdc27 ENSCSEP00000013775 ENSCSEP00000013775 fen1 fen1 psme1 psme1 cdc6 cdc6 anapc2 anapc2 LOC103381548 LOC103381548 mcm4 mcm4 anapc7 anapc7 ENSCSEP00000016476 ENSCSEP00000016476 mcm3 mcm3 psmb2 psmb2 pold2 pold2 LOC103397040 LOC103397040 pola1 pola1 psma8 psma8 psma2 psma2 psma3 psma3 psmc4 psmc4 psmd12 psmd12 rfc3 rfc3 LOC103398645 LOC103398645 LOC103395242 LOC103395242 LOC103393606 LOC103393606 ENSCSEP00000020096 ENSCSEP00000020096 ENSCSEP00000020203 ENSCSEP00000020203 rpa1 rpa1 bicral bicral pold1 pold1 LOC103393369 LOC103393369 dna2 dna2 psmd1 psmd1 ENSCSEP00000022777 ENSCSEP00000022777 FZR1 FZR1 gins2 gins2 LOC103378260 LOC103378260 psmd9 psmd9 LOC103381864 LOC103381864 ENSCSEP00000023759 ENSCSEP00000023759 skp1 skp1 psme2 psme2 psme3 psme3 anapc11 anapc11 psmc6 psmc6 pold4 pold4 Mcm9 Mcm9 UBB UBB cul1 cul1 uba52 uba52 psmb3 psmb3 LOC103398828 LOC103398828 LOC103382982 LOC103382982 anapc16 anapc16 mcm8 mcm8 tm7sf3 tm7sf3 gmnn gmnn ENSCSEP00000027438 ENSCSEP00000027438 POLE POLE ENSCSEP00000028052 ENSCSEP00000028052 LOC103389149 LOC103389149 anapc5 anapc5 ube2s ube2s ENSCSEP00000029270 ENSCSEP00000029270 psmd10 psmd10 Mcm6 Mcm6 psmc1 psmc1 anapc15 anapc15 LOC103389192 LOC103389192 psma6 psma6 rpa2 rpa2 rfc2 rfc2 psmb8 psmb8 LOC103393839 LOC103393839 LOC103393840 LOC103393840 pcna pcna psmb4 psmb4 psmc3 psmc3 pole4 pole4 LOC103397632 LOC103397632 Cdc23 Cdc23 ube2c ube2c cdc26 cdc26 LOC103386842 LOC103386842 ccne2 ccne2 mcm2 mcm2 prim1 prim1 rfc5 rfc5 LOC103396604 LOC103396604 PSMB11 PSMB11 ENSCSEP00000033782 ENSCSEP00000033782 pold3 pold3 anapc4 anapc4 psmb1 psmb1 ccne1 ccne1 gins3 gins3 psmd14 psmd14 meiob meiob psma1 psma1 orc1 orc1 psmd5 psmd5 rps27a rps27a LOC103379914 LOC103379914 PSMD4 PSMD4 orc3 orc3 ENSCSEP00000004184 ENSCSEP00000004184 gins1 gins1 fam89a fam89a mcm7 mcm7 cdk2 cdk2 LOC103388354 LOC103388354 LOC103388353 LOC103388353 ccna2 ccna2 psma5 psma5 pola2 pola2 pole2 pole2 RCBTB1 RCBTB1 rfc1 rfc1 cdc16 cdc16 psmd6 psmd6 psmd7 psmd7 psmb6 psmb6 psmd13 psmd13 pole3 pole3 anapc10 anapc10 psme4 psme4 kxd1 kxd1 LOC103381415 LOC103381415 PSMC5 PSMC5 ENSCSEP00000009900 ENSCSEP00000009900 ENSCSEP00000009964 ENSCSEP00000009964 rbx1 rbx1 Pold2 Pold2 orc4 orc4 rcbtb2 rcbtb2 Orc5 Orc5 ENSCSEP00000011109 ENSCSEP00000011109
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rfc4Replication factor C (activator 1) 4. (358 aa)
bicraBRD4 interacting chromatin remodeling complex associated protein. (1789 aa)
LOC103394542Proteasome 26S subunit, non-ATPase 4a. (371 aa)
LOC103389639Proteasome subunit beta. (277 aa)
LOC103399400ANK_REP_REGION domain-containing protein. (81 aa)
ENSCSEP00000011696Uncharacterized protein. (103 aa)
gins4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa)
psmd3Proteasome 26S subunit, non-ATPase 3. (520 aa)
ENSCSEP00000012655DNA_pol_D_N domain-containing protein. (396 aa)
cdc27Cell division cycle 27. (735 aa)
Cdc27Uncharacterized protein. (81 aa)
ENSCSEP00000013775Uncharacterized protein. (292 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
psme1Proteasome activator subunit 1. (249 aa)
cdc6Cell division cycle 6 homolog (S. cerevisiae). (526 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (807 aa)
LOC103381548Uncharacterized protein. (1808 aa)
mcm4DNA helicase; Belongs to the MCM family. (859 aa)
anapc7Anaphase promoting complex subunit 7. (565 aa)
ENSCSEP00000016476DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (473 aa)
mcm3DNA helicase; Belongs to the MCM family. (813 aa)
psmb2Proteasome subunit beta. (187 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (519 aa)
LOC103397040Uncharacterized protein. (231 aa)
pola1DNA polymerase. (1429 aa)
psma8Proteasome subunit alpha type. (251 aa)
psma2Proteasome subunit alpha type. (234 aa)
psma3Proteasome subunit alpha type. (255 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (456 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
LOC103398645Proteasome subunit alpha type. (261 aa)
LOC103395242Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (633 aa)
LOC103393606PCI domain-containing protein. (422 aa)
ENSCSEP00000020096Uncharacterized protein. (707 aa)
ENSCSEP00000020203DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (315 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
bicralBRD4 interacting chromatin remodeling complex associated protein like. (774 aa)
pold1DNA polymerase. (1077 aa)
LOC103393369WD_REPEATS_REGION domain-containing protein. (476 aa)
dna2DNA replication helicase/nuclease 2. (1185 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (959 aa)
ENSCSEP00000022777DNA helicase; Belongs to the MCM family. (683 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (497 aa)
gins2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (171 aa)
LOC103378260Proteasome subunit alpha type. (267 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (212 aa)
LOC103381864Proteasome 26S subunit, non-ATPase 11b. (422 aa)
ENSCSEP00000023759Ubiquitin-like domain-containing protein. (92 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (193 aa)
psme2Proteasome activator subunit 2. (245 aa)
psme3Proteasome activator subunit 3. (240 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (407 aa)
pold4Si:dkey-28b4.7. (109 aa)
Mcm9Uncharacterized protein. (131 aa)
UBBUbiquitin B. (744 aa)
cul1Cullin 1b; Belongs to the cullin family. (766 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (151 aa)
psmb3Proteasome subunit beta. (205 aa)
LOC103398828Fizzy/cell division cycle 20 related 1b. (487 aa)
LOC103382982Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
anapc16Anaphase promoting complex subunit 16. (108 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (859 aa)
tm7sf3Transmembrane 7 superfamily member 3. (505 aa)
gmnnGeminin DNA replication inhibitor. (225 aa)
ENSCSEP00000027438Zgc:110269. (389 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1996 aa)
ENSCSEP00000028052Chromatin licensing and DNA replication factor 1. (633 aa)
LOC103389149Proteasome subunit beta. (276 aa)
anapc5Anaphase promoting complex subunit 5. (698 aa)
ube2sUbiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (236 aa)
ENSCSEP00000029270Uncharacterized protein. (86 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (209 aa)
Mcm6DNA helicase; Belongs to the MCM family. (688 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
anapc15Anaphase promoting complex subunit 15. (122 aa)
LOC103389192S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (425 aa)
psma6Proteasome subunit alpha type. (246 aa)
rpa2Replication protein A2. (274 aa)
rfc2Replication factor C (activator 1) 2. (355 aa)
psmb8Proteasome subunit beta. (271 aa)
LOC103393839Proteasome subunit beta 13a. (281 aa)
LOC103393840Proteasome subunit beta 12. (217 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (226 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (404 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (130 aa)
LOC103397632SCY domain-containing protein. (159 aa)
Cdc23CDC23 (cell division cycle 23, yeast, homolog). (291 aa)
ube2cUbiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (174 aa)
cdc26Cell division cycle 26 homolog. (138 aa)
LOC103386842Proteasome inhibitor subunit 1. (280 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (399 aa)
mcm2DNA helicase; Belongs to the MCM family. (885 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (396 aa)
rfc5Replication factor C (activator 1) 5. (338 aa)
LOC103396604Proteasome subunit beta. (278 aa)
PSMB11Proteasome subunit beta. (304 aa)
ENSCSEP00000033782DNA ligase. (633 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (419 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (799 aa)
psmb1Proteasome subunit beta. (237 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (426 aa)
gins3GINS complex subunit 3. (211 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
meiobMethionine sulfoxide reductase B1b. (436 aa)
psma1Proteasome subunit alpha type. (266 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (903 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (504 aa)
rps27aRibosomal protein S27a. (156 aa)
LOC103379914Proteasome subunit alpha type. (261 aa)
PSMD4VWFA domain-containing protein. (375 aa)
orc3Origin recognition complex, subunit 3. (719 aa)
ENSCSEP00000004184Anaphase promoting complex subunit 1. (1825 aa)
gins1GINS complex subunit 1 (Psf1 homolog). (196 aa)
fam89aFamily with sequence similarity 89 member A. (178 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC103388354UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (194 aa)
LOC103388353Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family. (202 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (447 aa)
psma5Proteasome subunit alpha type. (241 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (601 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
RCBTB1Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (637 aa)
rfc1Replication factor C subunit 1. (1083 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (617 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (330 aa)
psmb6Proteasome subunit beta. (234 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (391 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (149 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (186 aa)
psme4Proteasome activator subunit 4a. (1847 aa)
kxd1KxDL motif containing 1. (180 aa)
LOC103381415Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (398 aa)
PSMC526S proteasome regulatory subunit 8. (398 aa)
ENSCSEP00000009900PI31_Prot_N domain-containing protein. (194 aa)
ENSCSEP00000009964Uncharacterized protein. (85 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
Pold2Uncharacterized protein. (78 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (554 aa)
Orc5Origin recognition complex, subunit 5. (435 aa)
ENSCSEP00000011109Proteasome 26S subunit, non-ATPase 8. (257 aa)
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
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