STRINGSTRING
ywhaz ywhaz rmi2 rmi2 YWHAB YWHAB LOC103385609 LOC103385609 babam2 babam2 Atm Atm LOC103377546 LOC103377546 wee1 wee1 meiob meiob abraxas1 abraxas1 tdrd3 tdrd3 rfc4 rfc4 ENSCSEP00000012570 ENSCSEP00000012570 rhno1 rhno1 exo1 exo1 ENSCSEP00000025964 ENSCSEP00000025964 ENSCSEP00000025093 ENSCSEP00000025093 ENSCSEP00000024591 ENSCSEP00000024591 ccnb1 ccnb1 LOC103377125 LOC103377125 brca1 brca1 rad9a rad9a ENSCSEP00000010737 ENSCSEP00000010737 ENSCSEP00000010689 ENSCSEP00000010689 ENSCSEP00000010388 ENSCSEP00000010388 ENSCSEP00000009964 ENSCSEP00000009964 top3a top3a Rnf169 Rnf169 LOC103380153 LOC103380153 pias4 pias4 cdca7 cdca7 Cdc25b Cdc25b ywhae ywhae ENSCSEP00000006303 ENSCSEP00000006303 ENSCSEP00000006274 ENSCSEP00000006274 atr atr LOC103380040 LOC103380040 ENSCSEP00000005051 ENSCSEP00000005051 ENSCSEP00000018191 ENSCSEP00000018191 rfc3 rfc3 rmi1 rmi1 rbbp8 rbbp8 LOC103396322 LOC103396322 LOC103378165 LOC103378165 LOC103395178 LOC103395178 Rad9b Rad9b ube2v2 ube2v2 chek1 chek1 atrip atrip LOC103382819 LOC103382819 tp53bp1 tp53bp1 ENSCSEP00000011696 ENSCSEP00000011696 exd2 exd2 ENSCSEP00000014113 ENSCSEP00000014113 rad17 rad17 ENSCSEP00000014019 ENSCSEP00000014019 Rnf168 Rnf168 cdca7l cdca7l chek2 chek2 LOC103395242 LOC103395242 rpa1 rpa1 blm blm Whsc1 Whsc1 dna2 dna2 slf1 slf1 kat5 kat5 ENSCSEP00000023029 ENSCSEP00000023029 ENSCSEP00000023037 ENSCSEP00000023037 HIST1H4J HIST1H4J ENSCSEP00000023079 ENSCSEP00000023079 ENSCSEP00000023097 ENSCSEP00000023097 ENSCSEP00000023236 ENSCSEP00000023236 rad50 rad50 LOC103386524 LOC103386524 LOC103394270 LOC103394270 babam1 babam1 LOC103389086 LOC103389086 ankrd12 ankrd12 mre11 mre11 brcc3 brcc3 ENSCSEP00000027862 ENSCSEP00000027862 hus1 hus1 rpa2 rpa2 rfc2 rfc2 topbp1 topbp1 rad1 rad1 cdk1 cdk1 ENSCSEP00000031260 ENSCSEP00000031260 rnf8 rnf8 rfc5 rfc5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ywhaz14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
rmi2RecQ mediated genome instability 2. (163 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (244 aa)
LOC103385609Ubiquitin-conjugating enzyme E2 variant 1. (147 aa)
babam2BRISC and BRCA1 A complex member 2. (386 aa)
AtmNon-specific serine/threonine protein kinase. (3052 aa)
LOC103377546Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a; Belongs to the 14-3-3 family. (258 aa)
wee1Wee1-like protein kinase. (616 aa)
meiobMethionine sulfoxide reductase B1b. (436 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (346 aa)
tdrd3Tudor domain containing 3. (773 aa)
rfc4Replication factor C (activator 1) 4. (358 aa)
ENSCSEP00000012570Histone H2A; Belongs to the histone H2A family. (218 aa)
rhno1Si:ch73-352p4.5. (301 aa)
exo1Exonuclease 1. (597 aa)
ENSCSEP00000025964XPGN domain-containing protein. (140 aa)
ENSCSEP00000025093Uncharacterized protein. (194 aa)
ENSCSEP0000002459114_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (400 aa)
LOC103377125Si:dkey-21a6.5. (269 aa)
brca1Uncharacterized protein. (1217 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (394 aa)
ENSCSEP00000010737Histone H2B; Belongs to the histone H2B family. (117 aa)
ENSCSEP00000010689Histone H2B; Belongs to the histone H2B family. (114 aa)
ENSCSEP00000010388Histone H2B; Belongs to the histone H2B family. (122 aa)
ENSCSEP00000009964Uncharacterized protein. (85 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa)
Rnf169Ring finger protein 169. (665 aa)
LOC103380153Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
pias4Protein inhibitor of activated STAT, 4a. (499 aa)
cdca7Cell division cycle associated 7a. (401 aa)
Cdc25bRhodanese domain-containing protein. (568 aa)
ywhaeTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (254 aa)
ENSCSEP00000006303Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
ENSCSEP00000006274Histone H2B; Belongs to the histone H2B family. (114 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2429 aa)
LOC103380040Wee1-like protein kinase. (546 aa)
ENSCSEP00000005051Histone H2B; Belongs to the histone H2B family. (112 aa)
ENSCSEP00000018191SAE2 domain-containing protein. (90 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (642 aa)
rbbp8CtIP_N domain-containing protein. (539 aa)
LOC103396322Histone H2B; Belongs to the histone H2B family. (116 aa)
LOC1033781653-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
LOC1033951783-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1; Belongs to the 14-3-3 family. (247 aa)
Rad9bUncharacterized protein. (177 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (158 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (488 aa)
atripUncharacterized protein. (600 aa)
LOC103382819UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1101 aa)
ENSCSEP00000011696Uncharacterized protein. (103 aa)
exd2Exonuclease 3'-5' domain containing 2. (728 aa)
ENSCSEP00000014113Histone domain-containing protein; Belongs to the histone H2B family. (109 aa)
rad17RAD17 checkpoint clamp loader component. (640 aa)
ENSCSEP00000014019Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (89 aa)
Rnf168RING-type domain-containing protein. (117 aa)
cdca7lCell division cycle associated 7b. (416 aa)
chek2Checkpoint kinase 2. (550 aa)
LOC103395242Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (633 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
blmBLM RecQ like helicase. (1300 aa)
Whsc1Nuclear receptor binding SET domain protein 2. (931 aa)
dna2DNA replication helicase/nuclease 2. (1185 aa)
slf1Uncharacterized protein. (788 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (540 aa)
ENSCSEP00000023029Histone H2B; Belongs to the histone H2B family. (113 aa)
ENSCSEP00000023037annotation not available (67 aa)
HIST1H4JHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSCSEP00000023079Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSCSEP00000023097Histone H2B; Belongs to the histone H2B family. (114 aa)
ENSCSEP00000023236RecQ helicase-like 4. (807 aa)
rad50RAD50 homolog, double strand break repair protein. (1319 aa)
LOC10338652414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa)
LOC103394270Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (247 aa)
babam1BRISC and BRCA1 A complex member 1. (316 aa)
LOC103389086UBIQUITIN_CONJUGAT_2 domain-containing protein. (144 aa)
ankrd12Ankyrin repeat domain 12. (1932 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (718 aa)
brcc3BRCA1/BRCA2-containing complex, subunit 3. (236 aa)
ENSCSEP00000027862Ankyrin repeat domain 11. (2775 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (281 aa)
rpa2Replication protein A2. (274 aa)
rfc2Replication factor C (activator 1) 2. (355 aa)
topbp1DNA topoisomerase II binding protein 1. (1517 aa)
rad1RAD1 homolog (S. pombe). (277 aa)
cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (269 aa)
ENSCSEP00000031260Uncharacterized protein; Belongs to the histone H2B family. (112 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa)
rfc5Replication factor C (activator 1) 5. (338 aa)
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
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