STRINGSTRING
YWHAB YWHAB psmb1 psmb1 ccnb3 ccnb3 rfc4 rfc4 tdrd3 tdrd3 abraxas1 abraxas1 psmd14 psmd14 meiob meiob psma1 psma1 wee1 wee1 orc1 orc1 LOC103377125 LOC103377125 psmd5 psmd5 rps27a rps27a cdk1 cdk1 LOC103377546 LOC103377546 dbf4 dbf4 LOC103379914 LOC103379914 PSMD4 PSMD4 Atm Atm orc3 orc3 cntd2 cntd2 babam2 babam2 mcm7 mcm7 ENSCSEP00000005051 ENSCSEP00000005051 LOC103380040 LOC103380040 atr atr ENSCSEP00000006274 ENSCSEP00000006274 ENSCSEP00000006303 ENSCSEP00000006303 cdk2 cdk2 psma5 psma5 RCBTB1 RCBTB1 ywhae ywhae cdca7 cdca7 psmd6 psmd6 psmd7 psmd7 pias4 pias4 LOC103380153 LOC103380153 psmb6 psmb6 psmd13 psmd13 Rnf169 Rnf169 psme4 psme4 kxd1 kxd1 LOC103381415 LOC103381415 PSMC5 PSMC5 ENSCSEP00000009900 ENSCSEP00000009900 top3a top3a ENSCSEP00000009964 ENSCSEP00000009964 ENSCSEP00000010388 ENSCSEP00000010388 ENSCSEP00000010689 ENSCSEP00000010689 orc4 orc4 ENSCSEP00000010737 ENSCSEP00000010737 rcbtb2 rcbtb2 Orc5 Orc5 rad9a rad9a ENSCSEP00000011109 ENSCSEP00000011109 LOC103394542 LOC103394542 brca1 brca1 LOC103389639 LOC103389639 LOC103399400 LOC103399400 ENSCSEP00000011696 ENSCSEP00000011696 rhno1 rhno1 ENSCSEP00000012570 ENSCSEP00000012570 chek2 chek2 psmd3 psmd3 LOC103379018 LOC103379018 ENSCSEP00000013775 ENSCSEP00000013775 cdca7l cdca7l Rnf168 Rnf168 ENSCSEP00000014019 ENSCSEP00000014019 rad17 rad17 ENSCSEP00000014113 ENSCSEP00000014113 pkmyt1 pkmyt1 psme1 psme1 exd2 exd2 tp53bp1 tp53bp1 cdc6 cdc6 LOC103382819 LOC103382819 atrip atrip chek1 chek1 LOC103381548 LOC103381548 ube2v2 ube2v2 mcm4 mcm4 Rad9b Rad9b mcm3 mcm3 psmb2 psmb2 CLSPN CLSPN LOC103395178 LOC103395178 LOC103378165 LOC103378165 LOC103396322 LOC103396322 psma8 psma8 psma2 psma2 rbbp8 rbbp8 ENSCSEP00000018191 ENSCSEP00000018191 psma3 psma3 psmc4 psmc4 psmd12 psmd12 rfc3 rfc3 rmi1 rmi1 LOC103398645 LOC103398645 LOC103395242 LOC103395242 LOC103393606 LOC103393606 rpa1 rpa1 ywhaz ywhaz wdr41 wdr41 blm blm Whsc1 Whsc1 dna2 dna2 psmd1 psmd1 slf1 slf1 ENSCSEP00000022777 ENSCSEP00000022777 kat5 kat5 ENSCSEP00000023029 ENSCSEP00000023029 ENSCSEP00000023037 ENSCSEP00000023037 HIST1H4J HIST1H4J ENSCSEP00000023079 ENSCSEP00000023079 ENSCSEP00000023097 ENSCSEP00000023097 ENSCSEP00000023236 ENSCSEP00000023236 LOC103378260 LOC103378260 psmd9 psmd9 rad50 rad50 LOC103381864 LOC103381864 LOC103386524 LOC103386524 ENSCSEP00000023783 ENSCSEP00000023783 ENSCSEP00000023807 ENSCSEP00000023807 LOC103394270 LOC103394270 psme2 psme2 psme3 psme3 ccnb1 ccnb1 Cdc25b Cdc25b psmc6 psmc6 ENSCSEP00000024591 ENSCSEP00000024591 Mcm9 Mcm9 ENSCSEP00000025093 ENSCSEP00000025093 UBB UBB psmb3 psmb3 ENSCSEP00000025964 ENSCSEP00000025964 exo1 exo1 babam1 babam1 LOC103382982 LOC103382982 LOC103389086 LOC103389086 ankrd12 ankrd12 mre11 mre11 PIEZO2 PIEZO2 mcm8 mcm8 brcc3 brcc3 ENSCSEP00000027503 ENSCSEP00000027503 cdc7 cdc7 ENSCSEP00000027862 ENSCSEP00000027862 LOC103389149 LOC103389149 hus1 hus1 psmd10 psmd10 Mcm6 Mcm6 psmc1 psmc1 psma6 psma6 rpa2 rpa2 rfc2 rfc2 psmb8 psmb8 LOC103393840 LOC103393840 topbp1 topbp1 psmb4 psmb4 cdc45 cdc45 psmc3 psmc3 ENSCSEP00000030782 ENSCSEP00000030782 ENSCSEP00000030790 ENSCSEP00000030790 rad1 rad1 ENSCSEP00000031260 ENSCSEP00000031260 Mcm10 Mcm10 LOC103386842 LOC103386842 rnf8 rnf8 mcm2 mcm2 rfc5 rfc5 LOC103396604 LOC103396604 PSMB11 PSMB11 ENSCSEP00000033017 ENSCSEP00000033017 rmi2 rmi2 LOC103385609 LOC103385609
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (244 aa)
psmb1Proteasome subunit beta. (237 aa)
ccnb3Cyclin B3; Belongs to the cyclin family. (419 aa)
rfc4Replication factor C (activator 1) 4. (358 aa)
tdrd3Tudor domain containing 3. (773 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (346 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
meiobMethionine sulfoxide reductase B1b. (436 aa)
psma1Proteasome subunit alpha type. (266 aa)
wee1Wee1-like protein kinase. (616 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (903 aa)
LOC103377125Si:dkey-21a6.5. (269 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (504 aa)
rps27aRibosomal protein S27a. (156 aa)
cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (269 aa)
LOC103377546Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a; Belongs to the 14-3-3 family. (258 aa)
dbf4DBF4 zinc finger. (528 aa)
LOC103379914Proteasome subunit alpha type. (261 aa)
PSMD4VWFA domain-containing protein. (375 aa)
AtmNon-specific serine/threonine protein kinase. (3052 aa)
orc3Origin recognition complex, subunit 3. (719 aa)
cntd2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (393 aa)
babam2BRISC and BRCA1 A complex member 2. (386 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
ENSCSEP00000005051Histone H2B; Belongs to the histone H2B family. (112 aa)
LOC103380040Wee1-like protein kinase. (546 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2429 aa)
ENSCSEP00000006274Histone H2B; Belongs to the histone H2B family. (114 aa)
ENSCSEP00000006303Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
psma5Proteasome subunit alpha type. (241 aa)
RCBTB1Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (637 aa)
ywhaeTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (254 aa)
cdca7Cell division cycle associated 7a. (401 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (330 aa)
pias4Protein inhibitor of activated STAT, 4a. (499 aa)
LOC103380153Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
psmb6Proteasome subunit beta. (234 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (391 aa)
Rnf169Ring finger protein 169. (665 aa)
psme4Proteasome activator subunit 4a. (1847 aa)
kxd1KxDL motif containing 1. (180 aa)
LOC103381415Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (398 aa)
PSMC526S proteasome regulatory subunit 8. (398 aa)
ENSCSEP00000009900PI31_Prot_N domain-containing protein. (194 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa)
ENSCSEP00000009964Uncharacterized protein. (85 aa)
ENSCSEP00000010388Histone H2B; Belongs to the histone H2B family. (122 aa)
ENSCSEP00000010689Histone H2B; Belongs to the histone H2B family. (114 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
ENSCSEP00000010737Histone H2B; Belongs to the histone H2B family. (117 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (554 aa)
Orc5Origin recognition complex, subunit 5. (435 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (394 aa)
ENSCSEP00000011109Proteasome 26S subunit, non-ATPase 8. (257 aa)
LOC103394542Proteasome 26S subunit, non-ATPase 4a. (371 aa)
brca1Uncharacterized protein. (1217 aa)
LOC103389639Proteasome subunit beta. (277 aa)
LOC103399400ANK_REP_REGION domain-containing protein. (81 aa)
ENSCSEP00000011696Uncharacterized protein. (103 aa)
rhno1Si:ch73-352p4.5. (301 aa)
ENSCSEP00000012570Histone H2A; Belongs to the histone H2A family. (218 aa)
chek2Checkpoint kinase 2. (550 aa)
psmd3Proteasome 26S subunit, non-ATPase 3. (520 aa)
LOC103379018Cyclin B2; Belongs to the cyclin family. (394 aa)
ENSCSEP00000013775Uncharacterized protein. (292 aa)
cdca7lCell division cycle associated 7b. (416 aa)
Rnf168RING-type domain-containing protein. (117 aa)
ENSCSEP00000014019Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (89 aa)
rad17RAD17 checkpoint clamp loader component. (640 aa)
ENSCSEP00000014113Histone domain-containing protein; Belongs to the histone H2B family. (109 aa)
pkmyt1Protein kinase, membrane associated tyrosine/threonine 1. (586 aa)
psme1Proteasome activator subunit 1. (249 aa)
exd2Exonuclease 3'-5' domain containing 2. (728 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1101 aa)
cdc6Cell division cycle 6 homolog (S. cerevisiae). (526 aa)
LOC103382819UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
atripUncharacterized protein. (600 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (488 aa)
LOC103381548Uncharacterized protein. (1808 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (158 aa)
mcm4DNA helicase; Belongs to the MCM family. (859 aa)
Rad9bUncharacterized protein. (177 aa)
mcm3DNA helicase; Belongs to the MCM family. (813 aa)
psmb2Proteasome subunit beta. (187 aa)
CLSPNClaspin. (1352 aa)
LOC1033951783-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1; Belongs to the 14-3-3 family. (247 aa)
LOC1033781653-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
LOC103396322Histone H2B; Belongs to the histone H2B family. (116 aa)
psma8Proteasome subunit alpha type. (251 aa)
psma2Proteasome subunit alpha type. (234 aa)
rbbp8CtIP_N domain-containing protein. (539 aa)
ENSCSEP00000018191SAE2 domain-containing protein. (90 aa)
psma3Proteasome subunit alpha type. (255 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (456 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (642 aa)
LOC103398645Proteasome subunit alpha type. (261 aa)
LOC103395242Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (633 aa)
LOC103393606PCI domain-containing protein. (422 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
ywhaz14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
wdr41WD repeat domain 41. (450 aa)
blmBLM RecQ like helicase. (1300 aa)
Whsc1Nuclear receptor binding SET domain protein 2. (931 aa)
dna2DNA replication helicase/nuclease 2. (1185 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (959 aa)
slf1Uncharacterized protein. (788 aa)
ENSCSEP00000022777DNA helicase; Belongs to the MCM family. (683 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (540 aa)
ENSCSEP00000023029Histone H2B; Belongs to the histone H2B family. (113 aa)
ENSCSEP00000023037annotation not available (67 aa)
HIST1H4JHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSCSEP00000023079Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSCSEP00000023097Histone H2B; Belongs to the histone H2B family. (114 aa)
ENSCSEP00000023236RecQ helicase-like 4. (807 aa)
LOC103378260Proteasome subunit alpha type. (267 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (212 aa)
rad50RAD50 homolog, double strand break repair protein. (1319 aa)
LOC103381864Proteasome 26S subunit, non-ATPase 11b. (422 aa)
LOC10338652414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa)
ENSCSEP00000023783PIEZO domain-containing protein. (1341 aa)
ENSCSEP00000023807Piezo_RRas_bdg domain-containing protein. (584 aa)
LOC103394270Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (247 aa)
psme2Proteasome activator subunit 2. (245 aa)
psme3Proteasome activator subunit 3. (240 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (400 aa)
Cdc25bRhodanese domain-containing protein. (568 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (407 aa)
ENSCSEP0000002459114_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
Mcm9Uncharacterized protein. (131 aa)
ENSCSEP00000025093Uncharacterized protein. (194 aa)
UBBUbiquitin B. (744 aa)
psmb3Proteasome subunit beta. (205 aa)
ENSCSEP00000025964XPGN domain-containing protein. (140 aa)
exo1Exonuclease 1. (597 aa)
babam1BRISC and BRCA1 A complex member 1. (316 aa)
LOC103382982Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
LOC103389086UBIQUITIN_CONJUGAT_2 domain-containing protein. (144 aa)
ankrd12Ankyrin repeat domain 12. (1932 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (718 aa)
PIEZO2Piezo-type mechanosensitive ion channel component. (2783 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (859 aa)
brcc3BRCA1/BRCA2-containing complex, subunit 3. (236 aa)
ENSCSEP00000027503Piezo-type mechanosensitive ion channel component. (2315 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (582 aa)
ENSCSEP00000027862Ankyrin repeat domain 11. (2775 aa)
LOC103389149Proteasome subunit beta. (276 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (281 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (209 aa)
Mcm6DNA helicase; Belongs to the MCM family. (688 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
psma6Proteasome subunit alpha type. (246 aa)
rpa2Replication protein A2. (274 aa)
rfc2Replication factor C (activator 1) 2. (355 aa)
psmb8Proteasome subunit beta. (271 aa)
LOC103393840Proteasome subunit beta 12. (217 aa)
topbp1DNA topoisomerase II binding protein 1. (1517 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (226 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (568 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (404 aa)
ENSCSEP00000030782Uncharacterized protein. (506 aa)
ENSCSEP00000030790Uncharacterized protein. (303 aa)
rad1RAD1 homolog (S. pombe). (277 aa)
ENSCSEP00000031260Uncharacterized protein; Belongs to the histone H2B family. (112 aa)
Mcm10Zf-primase domain-containing protein. (203 aa)
LOC103386842Proteasome inhibitor subunit 1. (280 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (540 aa)
mcm2DNA helicase; Belongs to the MCM family. (885 aa)
rfc5Replication factor C (activator 1) 5. (338 aa)
LOC103396604Proteasome subunit beta. (278 aa)
PSMB11Proteasome subunit beta. (304 aa)
ENSCSEP00000033017GTSE1_N domain-containing protein. (700 aa)
rmi2RecQ mediated genome instability 2. (163 aa)
LOC103385609Ubiquitin-conjugating enzyme E2 variant 1. (147 aa)
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
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