STRINGSTRING
LOC103395304 LOC103395304 smad1 smad1 LOC103376789 LOC103376789 ltbp2 ltbp2 itgb6 itgb6 LOC103377523 LOC103377523 LOC103379842 LOC103379842 rps27a rps27a bmpr1a bmpr1a rnf111 rnf111 atp1b4 atp1b4 bmp2 bmp2 nog nog fkbp1b fkbp1b fstl3 fstl3 LOC103384692 LOC103384692 LOC103384737 LOC103384737 prkcz prkcz ccnq ccnq itgb5 itgb5 LOC103385953 LOC103385953 LOC103387108 LOC103387108 ENSCSEP00000006129 ENSCSEP00000006129 irx2 irx2 LOC103388329 LOC103388329 tfdp1 tfdp1 LOC103388364 LOC103388364 bmpr2 bmpr2 zcchc4 zcchc4 LOC103386120 LOC103386120 meis2 meis2 ENSCSEP00000007724 ENSCSEP00000007724 grem2 grem2 LOC103391805 LOC103391805 LOC103380097 LOC103380097 LOC103377845 LOC103377845 FBN1 FBN1 amh amh LOC103390834 LOC103390834 LOC103378886 LOC103378886 kxd1 kxd1 smurf1 smurf1 ENSCSEP00000010572 ENSCSEP00000010572 LOC103397887 LOC103397887 acvr2a acvr2a LOC103385089 LOC103385089 smad6 smad6 ACVR1B ACVR1B LOC103380246 LOC103380246 ENSCSEP00000011075 ENSCSEP00000011075 ENSCSEP00000011164 ENSCSEP00000011164 ENSCSEP00000011399 ENSCSEP00000011399 LOC103381463 LOC103381463 ENSCSEP00000011691 ENSCSEP00000011691 irx6 irx6 MAPK1 MAPK1 LOC103376883 LOC103376883 ENSCSEP00000012019 ENSCSEP00000012019 ENSCSEP00000012341 ENSCSEP00000012341 ENSCSEP00000012708 ENSCSEP00000012708 itgb8 itgb8 irx3 irx3 LOC103389682 LOC103389682 LOC103389823 LOC103389823 sarnp sarnp cdk9 cdk9 LOC103397458 LOC103397458 LOC103397451 LOC103397451 LOC103383976 LOC103383976 LOC103388716 LOC103388716 LOC103389871 LOC103389871 AMHR2 AMHR2 tgfb2 tgfb2 LOC103397049 LOC103397049 acvr1 acvr1 ACVR1C ACVR1C LOC103376967 LOC103376967 LOC103381684 LOC103381684 LOC103394100 LOC103394100 LOC103389944 LOC103389944 LOC103394101 LOC103394101 PARD3 PARD3 smad9 smad9 SMAD3 SMAD3 LOC103379083 LOC103379083 bmpr1b bmpr1b LOC103378224 LOC103378224 ldlrad4 ldlrad4 LOC103383047 LOC103383047 LOC103384177 LOC103384177 LOC103391130 LOC103391130 LOC103377095 LOC103377095 furin furin LOC103377099 LOC103377099 ENSCSEP00000021801 ENSCSEP00000021801 LOC103396440 LOC103396440 LOC103393525 LOC103393525 LOC103384202 LOC103384202 LOC103396445 LOC103396445 LOC103393707 LOC103393707 ENSCSEP00000022461 ENSCSEP00000022461 LOC103396454 LOC103396454 ENSCSEP00000022604 ENSCSEP00000022604 ENSCSEP00000022726 ENSCSEP00000022726 TGFBR2 TGFBR2 ENSCSEP00000023418 ENSCSEP00000023418 ENSCSEP00000023438 ENSCSEP00000023438 LOC103393685 LOC103393685 cblc cblc ENSCSEP00000023759 ENSCSEP00000023759 ENSCSEP00000023925 ENSCSEP00000023925 LOC103394304 LOC103394304 Inhbb Inhbb LOC103390142 LOC103390142 ENSCSEP00000024394 ENSCSEP00000024394 CDK19 CDK19 ncor1 ncor1 UBB UBB strap strap uba52 uba52 cbl cbl ENSCSEP00000025842 ENSCSEP00000025842 LOC103395395 LOC103395395 cdk8 cdk8 ENSCSEP00000025934 ENSCSEP00000025934 LOC103396513 LOC103396513 LOC103390181 LOC103390181 SMAD4 SMAD4 Mkx Mkx LOC103390150 LOC103390150 LOC103385296 LOC103385296 LOC103393219 LOC103393219 LOC103377348 LOC103377348 ENSCSEP00000028810 ENSCSEP00000028810 ccnk ccnk snw1 snw1 LOC103381988 LOC103381988 CCNT2 CCNT2 LOC103397828 LOC103397828 drap1 drap1 ccnc ccnc LOC103392486 LOC103392486 nedd4l nedd4l smad7 smad7 LOC103397675 LOC103397675 smad2 smad2 fst fst LTBP3 LTBP3 rbl1 rbl1 LOC103386783 LOC103386783 Chrdl1 Chrdl1 ENSCSEP00000031757 ENSCSEP00000031757 TGFB3 TGFB3 LOC103385393 LOC103385393 ENSCSEP00000032108 ENSCSEP00000032108 parp1 parp1 LOC103391513 LOC103391513 e2f4 e2f4 zfyve9 zfyve9 ENSCSEP00000033647 ENSCSEP00000033647 ENSCSEP00000033853 ENSCSEP00000033853 LOC103379771 LOC103379771
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103395304F11 receptor, tandem duplicate 1. (297 aa)
smad1Mothers against decapentaplegic homolog. (470 aa)
LOC103376789Transforming growth factor beta; Belongs to the TGF-beta family. (403 aa)
ltbp2Uncharacterized protein. (2089 aa)
itgb6Integrin beta; Belongs to the integrin beta chain family. (777 aa)
LOC103377523TGFB-induced factor homeobox 1. (252 aa)
LOC103379842Par-6 family cell polarity regulator alpha. (440 aa)
rps27aRibosomal protein S27a. (156 aa)
bmpr1aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
rnf111Ring finger protein 111. (1040 aa)
atp1b4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (393 aa)
bmp2Bone morphogenetic protein 2. (422 aa)
nogNoggin; Belongs to the noggin family. (224 aa)
fkbp1bPeptidylprolyl isomerase. (108 aa)
fstl3Follistatin-like 3 (secreted glycoprotein). (248 aa)
LOC103384692Peptidylprolyl isomerase. (108 aa)
LOC103384737V-ski avian sarcoma viral oncogene homolog a. (736 aa)
prkczProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
ccnqCyclin Q; Belongs to the cyclin family. (258 aa)
itgb5Integrin beta; Belongs to the integrin beta chain family. (780 aa)
LOC103385953Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
LOC103387108Meis homeobox 1 b. (349 aa)
ENSCSEP00000006129Iroquois homeobox 1a. (397 aa)
irx2Iroquois homeobox 2a. (528 aa)
LOC103388329Iroquois homeobox 4a. (476 aa)
tfdp1Transcription factor. (412 aa)
LOC103388364Ubiquitin-like domain-containing protein. (81 aa)
bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1059 aa)
zcchc4Zinc finger, CCHC domain containing 4. (492 aa)
LOC103386120Homeobox domain-containing protein. (584 aa)
meis2Meis homeobox 2a. (510 aa)
ENSCSEP00000007724Tripartite motif containing 33. (1109 aa)
grem2Gremlin 2, DAN family BMP antagonist a. (167 aa)
LOC103391805Ubiquitin specific peptidase 9; Belongs to the peptidase C19 family. (2613 aa)
LOC103380097Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LOC103377845Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
FBN1Fibrillin 1. (2888 aa)
amhAnti-Mullerian hormone. (545 aa)
LOC103390834Transforming growth factor beta; Belongs to the TGF-beta family. (421 aa)
LOC103378886Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family. (949 aa)
kxd1KxDL motif containing 1. (180 aa)
smurf1E3 ubiquitin-protein ligase. (729 aa)
ENSCSEP00000010572Kazal-like domain-containing protein. (88 aa)
LOC103397887Mothers against decapentaplegic homolog. (510 aa)
acvr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
LOC103385089Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
smad6Mothers against decapentaplegic homolog. (491 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (497 aa)
LOC103380246Mothers against decapentaplegic homolog. (425 aa)
ENSCSEP00000011075Uncharacterized protein. (187 aa)
ENSCSEP00000011164annotation not available (71 aa)
ENSCSEP00000011399Uncharacterized protein. (102 aa)
LOC103381463Integrin beta; Belongs to the integrin beta chain family. (854 aa)
ENSCSEP00000011691Iroquois homeobox 5a. (448 aa)
irx6Iroquois homeobox 6a. (501 aa)
MAPK1Mitogen-activated protein kinase 1. (172 aa)
LOC103376883Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
ENSCSEP00000012019TB domain-containing protein. (86 aa)
ENSCSEP00000012341Par3_HAL_N_term domain-containing protein. (50 aa)
ENSCSEP00000012708annotation not available (68 aa)
itgb8Integrin beta; Belongs to the integrin beta chain family. (801 aa)
irx3Iroquois homeobox 3a. (431 aa)
LOC103389682Cyclin T2b; Belongs to the cyclin family. (542 aa)
LOC103389823TGF_BETA_2 domain-containing protein. (397 aa)
sarnpCyclin T1; Belongs to the cyclin family. (674 aa)
cdk9Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily. (393 aa)
LOC103397458Bone morphogenetic protein 10. (485 aa)
LOC103397451Mothers against decapentaplegic homolog. (437 aa)
LOC103383976E3 ubiquitin-protein ligase. (777 aa)
LOC103388716TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (586 aa)
LOC103389871Par-3 family cell polarity regulator beta a. (1243 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
LOC103397049TGF_BETA_2 domain-containing protein. (456 aa)
acvr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (683 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (610 aa)
LOC103376967Forkhead box H1. (519 aa)
LOC103381684STIP1 homology and U-Box containing protein 1. (159 aa)
LOC103394100Iroquois homeobox 1b. (465 aa)
LOC103389944Zinc finger, FYVE domain containing 16. (1421 aa)
LOC103394101Iroquois homeobox 4b. (461 aa)
PARD3Par-3 family cell polarity regulator. (1336 aa)
smad9Mothers against decapentaplegic homolog. (468 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC103379083Mothers against decapentaplegic homolog. (548 aa)
bmpr1bSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (541 aa)
LOC103378224Myeloid ecotropic viral integration site 3. (405 aa)
ldlrad4Low density lipoprotein receptor class A domain containing 4b. (320 aa)
LOC103383047CBFD_NFYB_HMF domain-containing protein. (177 aa)
LOC103384177DAN domain family, member 5. (260 aa)
LOC103391130Mothers against decapentaplegic homolog. (473 aa)
LOC103377095Mohawk homeobox a. (400 aa)
furinFurin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family. (834 aa)
LOC103377099BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
ENSCSEP00000021801BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a. (145 aa)
LOC103396440Peptidylprolyl isomerase. (109 aa)
LOC103393525Rho/rac guanine nucleotide exchange factor (GEF) 18b. (1428 aa)
LOC103384202JunB proto-oncogene, AP-1 transcription factor subunit a. (333 aa)
LOC103396445E2F transcription factor 5. (360 aa)
LOC103393707SMAD specific E3 ubiquitin protein ligase 2. (794 aa)
ENSCSEP00000022461C2 domain-containing protein. (54 aa)
LOC103396454SKI-like proto-oncogene a. (766 aa)
ENSCSEP00000022604Mothers against decapentaplegic homolog. (472 aa)
ENSCSEP00000022726Multiple endocrine neoplasia I. (411 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (578 aa)
ENSCSEP00000023418Uncharacterized protein. (258 aa)
ENSCSEP00000023438Uncharacterized protein. (259 aa)
LOC103393685JunB proto-oncogene, AP-1 transcription factor subunit b. (334 aa)
cblcCbl proto-oncogene C, E3 ubiquitin protein ligase. (550 aa)
ENSCSEP00000023759Ubiquitin-like domain-containing protein. (92 aa)
ENSCSEP00000023925TGF_BETA_2 domain-containing protein. (351 aa)
LOC103394304Mothers against decapentaplegic homolog. (573 aa)
InhbbInhibin subunit beta B. (577 aa)
LOC103390142Activin_recp domain-containing protein. (156 aa)
ENSCSEP00000024394Uncharacterized protein. (2211 aa)
CDK19Cyclin dependent kinase 19; Belongs to the protein kinase superfamily. (487 aa)
ncor1Nuclear receptor corepressor 1. (2354 aa)
UBBUbiquitin B. (744 aa)
strapSerine/threonine kinase receptor associated protein. (329 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (151 aa)
cblCbl proto-oncogene, E3 ubiquitin protein ligase. (952 aa)
ENSCSEP00000025842Latent transforming growth factor beta binding protein 1. (1174 aa)
LOC103395395Uncharacterized protein. (869 aa)
cdk8Cyclin-dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
ENSCSEP00000025934Integrin beta; Belongs to the integrin beta chain family. (750 aa)
LOC103396513Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (514 aa)
LOC103390181Bone morphogenetic protein 10, like. (442 aa)
SMAD4Mothers against decapentaplegic homolog. (503 aa)
MkxMohawk homeobox b. (263 aa)
LOC103390150Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (297 aa)
LOC103385296Iroquois homeobox 7. (331 aa)
LOC103393219Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (405 aa)
LOC103377348TGF_BETA_2 domain-containing protein. (406 aa)
ENSCSEP00000028810Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
ccnkCyclin K; Belongs to the cyclin family. (551 aa)
snw1SNW domain containing 1. (519 aa)
LOC103381988Noggin; Belongs to the noggin family. (209 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (723 aa)
LOC103397828Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
drap1DR1-associated protein 1 (negative cofactor 2 alpha). (233 aa)
ccncCyclin C; Belongs to the cyclin family. (283 aa)
LOC103392486Par-3 family cell polarity regulator beta b. (1190 aa)
nedd4lNEDD4 like E3 ubiquitin protein ligase. (1007 aa)
smad7Mothers against decapentaplegic homolog. (376 aa)
LOC103397675Zinc finger, FYVE domain containing 9b. (923 aa)
smad2Mothers against decapentaplegic homolog. (474 aa)
fstUncharacterized protein. (328 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1221 aa)
rbl1Retinoblastoma-like 1 (p107). (1066 aa)
LOC103386783Uncharacterized protein. (275 aa)
Chrdl1Chordin-like 2. (477 aa)
ENSCSEP00000031757Growth differentiation factor 2. (488 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
LOC103385393Peptidylprolyl isomerase. (109 aa)
ENSCSEP00000032108Noggin; Belongs to the noggin family. (215 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
LOC103391513TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
e2f4E2F transcription factor 4. (385 aa)
zfyve9Zinc finger, FYVE domain containing 9a. (1188 aa)
ENSCSEP00000033647Par-3 family cell polarity regulator alpha, b. (1325 aa)
ENSCSEP00000033853V-ski avian sarcoma viral oncogene homolog b. (658 aa)
LOC103379771Homeobox domain-containing protein. (385 aa)
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
Server load: low (22%) [HD]