STRINGSTRING
rad18 rad18 UBL5 UBL5 CCND1 CCND1 gabarap gabarap LOC103383557 LOC103383557 LOC103378402 LOC103378402 ENSCSEP00000005323 ENSCSEP00000005323 LOC103384746 LOC103384746 LOC103386108 LOC103386108 HDAC4 HDAC4 sumo1 sumo1 kras kras LOC103380153 LOC103380153 ENSCSEP00000010902 ENSCSEP00000010902 ddb2 ddb2 ENSCSEP00000012532 ENSCSEP00000012532 sf3a1 sf3a1 LOC103392195 LOC103392195 ddb1 ddb1 LOC103379080 LOC103379080 hdac5 hdac5 LOC103385228 LOC103385228 LOC103384237 LOC103384237 LOC103393067 LOC103393067 urm1 urm1 ENSCSEP00000026706 ENSCSEP00000026706 usp48 usp48 RAD23B RAD23B ENSCSEP00000028338 ENSCSEP00000028338 uba1 uba1 uhrf1 uhrf1 LOC103389192 LOC103389192 LOC103386727 LOC103386727 ufm1 ufm1 pcna pcna topbp1 topbp1 casp2 casp2 ubtd1 ubtd1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rad18RAD18 E3 ubiquitin protein ligase. (507 aa)
UBL5Ubiquitin like 5. (73 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (293 aa)
gabarapGABA(A) receptor-associated protein b. (122 aa)
LOC103383557Small ubiquitin-related modifier. (96 aa)
LOC103378402Small ubiquitin-related modifier. (94 aa)
ENSCSEP00000005323MDM2 proto-oncogene. (416 aa)
LOC103384746Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1005 aa)
LOC103386108Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (972 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1113 aa)
sumo1Small ubiquitin-related modifier. (101 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
LOC103380153Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
ENSCSEP00000010902Ubiquitin specific peptidase 18; Belongs to the peptidase C19 family. (278 aa)
ddb2Damage-specific DNA binding protein 2. (499 aa)
ENSCSEP00000012532Splicing factor 3a subunit 1. (263 aa)
sf3a1Splicing factor 3a, subunit 1. (786 aa)
LOC103392195Small ubiquitin-related modifier. (100 aa)
ddb1Damage-specific DNA binding protein 1. (1137 aa)
LOC103379080Cyclin D1; Belongs to the cyclin family. (293 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1110 aa)
LOC103385228Tyrosine-protein kinase. (551 aa)
LOC103384237Chromobox 4. (577 aa)
LOC103393067Chromobox homolog 4 (Pc class homolog, Drosophila). (565 aa)
urm1Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically [...] (101 aa)
ENSCSEP00000026706Ubiquilin 4. (660 aa)
usp48Ubiquitin specific peptidase 48; Belongs to the peptidase C19 family. (1062 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (382 aa)
ENSCSEP00000028338Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1037 aa)
uba1Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1055 aa)
uhrf1Ubiquitin-like with PHD and ring finger domains 1. (803 aa)
LOC103389192S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (425 aa)
LOC103386727RanBP-type and C3HC4-type zinc finger containing 1. (467 aa)
ufm1Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes. (87 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
topbp1DNA topoisomerase II binding protein 1. (1517 aa)
casp2Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (463 aa)
ubtd1Ubiquitin domain containing 1b. (239 aa)
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.