STRINGSTRING
c9orf72 c9orf72 akt1 akt1 EIF2AK4 EIF2AK4 LOC103378618 LOC103378618 ATG2B ATG2B WIPI1 WIPI1 LOC103378644 LOC103378644 ENSCSEP00000001078 ENSCSEP00000001078 ZFYVE1 ZFYVE1 mlst8 mlst8 LOC103390428 LOC103390428 LOC103399010 LOC103399010 pik3r4 pik3r4 tsc1 tsc1 Stx17 Stx17 hif1a hif1a dapk2 dapk2 ENSCSEP00000003705 ENSCSEP00000003705 gabarap gabarap ENSCSEP00000004267 ENSCSEP00000004267 ulk2 ulk2 atg9a atg9a bcl2l1 bcl2l1 prkcd prkcd LOC103387066 LOC103387066 traf6 traf6 LOC103389393 LOC103389393 LOC103385951 LOC103385951 ITPR1 ITPR1 Eif2s1 Eif2s1 ulk1 ulk1 LOC103376680 LOC103376680 pik3c3 pik3c3 LOC103391683 LOC103391683 Prkaa2 Prkaa2 LOC103387236 LOC103387236 mtor mtor deptor deptor LOC103386171 LOC103386171 sqstm1 sqstm1 kras kras map2k2 map2k2 ctsd ctsd atg3 atg3 LOC103378875 LOC103378875 LOC103391938 LOC103391938 LOC103393287 LOC103393287 smcr8 smcr8 map2k1 map2k1 ins ins becn1 becn1 LOC103378952 LOC103378952 LOC103377997 LOC103377997 LOC103387363 LOC103387363 hras hras LOC103383966 LOC103383966 LOC103397967 LOC103397967 atg4b atg4b Epas1 Epas1 prkacb prkacb atg16l1 atg16l1 LOC103392719 LOC103392719 atg5 atg5 ppp2cb ppp2cb ENSCSEP00000015414 ENSCSEP00000015414 rras2 rras2 ENSCSEP00000015545 ENSCSEP00000015545 LOC103395817 LOC103395817 LOC103394016 LOC103394016 LOC103394714 LOC103394714 tank tank MTMR4 MTMR4 LOC103379307 LOC103379307 LOC103396312 LOC103396312 LOC103389921 LOC103389921 rb1cc1 rb1cc1 LOC103391026 LOC103391026 LOC103396326 LOC103396326 LOC103377018 LOC103377018 LOC103395882 LOC103395882 LOC103395203 LOC103395203 rras rras akt1s1 akt1s1 LOC103397133 LOC103397133 pdpk1 pdpk1 hmgb1 hmgb1 LOC103379409 LOC103379409 uvrag uvrag atg101 atg101 pik3cb pik3cb LOC103397431 LOC103397431 wdr41 wdr41 LOC103397425 LOC103397425 LOC103392975 LOC103392975 pik3r1 pik3r1 LOC103389765 LOC103389765 LOC103395326 LOC103395326 stk11 stk11 LOC103378286 LOC103378286 dapk3 dapk3 LOC103384255 LOC103384255 LOC103393011 LOC103393011 LOC103390073 LOC103390073 ppp2ca ppp2ca eif2ak3 eif2ak3 LOC103391208 LOC103391208 rubcn rubcn bnip3 bnip3 LOC103396481 LOC103396481 LOC103394768 LOC103394768 LOC103387686 LOC103387686 LOC103378401 LOC103378401 rheb rheb bad bad LOC103396148 LOC103396148 ddit4 ddit4 ENSCSEP00000026957 ENSCSEP00000026957 ENSCSEP00000026996 ENSCSEP00000026996 LOC103393219 LOC103393219 mtmr14 mtmr14 rab39b rab39b atg4c atg4c bcl2 bcl2 map3k7 map3k7 Atg12 Atg12 LOC103390257 LOC103390257 mras mras AKT2 AKT2 LOC103397828 LOC103397828 Supt20h Supt20h LOC103380759 LOC103380759 LOC103388004 LOC103388004 catl catl dapk1 dapk1 PIK3CA PIK3CA RAB39B RAB39B RAB8A RAB8A snap29 snap29 rragc rragc mapk8 mapk8 LOC103391449 LOC103391449 LOC103380823 LOC103380823 igbp1 igbp1 LOC103383287 LOC103383287 Atg10 Atg10 Atg7 Atg7 LOC103379687 LOC103379687 ambra1 ambra1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
c9orf72Zgc:100846. (304 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1488 aa)
LOC103378618Uncharacterized protein. (164 aa)
ATG2BAutophagy related 2B. (2075 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (431 aa)
LOC103378644Lysosomal associated membrane protein 1. (370 aa)
ENSCSEP00000001078Insulin receptor substrate 4a. (1364 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (789 aa)
mlst8MTOR associated protein, LST8 homolog (S. cerevisiae). (326 aa)
LOC103390428Zgc:73226. (172 aa)
LOC103399010Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (575 aa)
pik3r4Phosphoinositide-3-kinase, regulatory subunit 4. (1327 aa)
tsc1TSC complex subunit 1b. (1273 aa)
Stx17Uncharacterized protein. (64 aa)
hif1aUncharacterized protein. (735 aa)
dapk2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (457 aa)
ENSCSEP00000003705Si:ch73-335l21.1. (1140 aa)
gabarapGABA(A) receptor-associated protein b. (122 aa)
ENSCSEP00000004267Cathepsin L.1; Belongs to the peptidase C1 family. (340 aa)
ulk2Unc-51 like autophagy activating kinase 2. (1027 aa)
atg9aAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (858 aa)
bcl2l1BCL2 like 1. (235 aa)
prkcdProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa)
LOC103387066Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (476 aa)
traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (576 aa)
LOC103389393Si:ch73-62l21.1. (595 aa)
LOC103385951Ras homolog, mTORC1 binding like 1. (184 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2721 aa)
Eif2s1Eukaryotic translation initiation factor 2, subunit 1 alpha b. (384 aa)
ulk1Unc-51 like autophagy activating kinase 1. (1035 aa)
LOC103376680Cathepsin 12; Belongs to the peptidase C1 family. (343 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (932 aa)
LOC103391683Lysosomal associated membrane protein 1b. (254 aa)
Prkaa2Non-specific serine/threonine protein kinase. (551 aa)
LOC103387236Uncharacterized protein. (228 aa)
mtorSerine/threonine-protein kinase TOR. (2382 aa)
deptorDEP domain containing MTOR-interacting protein. (455 aa)
LOC103386171RAB7a, member RAS oncogene family. (207 aa)
sqstm1Sequestosome 1. (427 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
ctsdPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (396 aa)
atg3Autophagy-related protein 3. (319 aa)
LOC103378875Uncharacterized protein. (128 aa)
LOC103391938Zgc:101559. (234 aa)
LOC103393287Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (398 aa)
smcr8Smith-Magenis syndrome chromosome region, candidate 8a. (939 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
insInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (113 aa)
becn1Beclin 1, autophagy related. (451 aa)
LOC103378952Death-associated protein kinase 2a; Belongs to the protein kinase superfamily. (492 aa)
LOC103377997High mobility group box 1b. (207 aa)
LOC103387363Mitogen-activated protein kinase. (438 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
LOC103383966Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (470 aa)
LOC103397967TSC complex subunit 1. (1108 aa)
atg4bCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (413 aa)
Epas1BHLH domain-containing protein. (88 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
atg16l1ATG16 autophagy related 16-like 1 (S. cerevisiae). (602 aa)
LOC103392719Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (452 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
ENSCSEP00000015414BH4_2 domain-containing protein. (214 aa)
rras2RAS related 2. (202 aa)
ENSCSEP00000015545Uncharacterized protein. (717 aa)
LOC103395817Uncharacterized protein. (467 aa)
LOC103394016Uncharacterized protein. (381 aa)
LOC103394714RAB42, member RAS oncogene family a. (218 aa)
tankTBD domain-containing protein. (340 aa)
MTMR4Myotubularin related protein 4. (1270 aa)
LOC103379307Tyrosine-protein kinase receptor. (1411 aa)
LOC103396312Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
LOC103389921Si:ch73-234b20.5. (103 aa)
rb1cc1RB1-inducible coiled-coil 1. (1623 aa)
LOC103391026Mitogen-activated protein kinase. (389 aa)
LOC103396326Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (810 aa)
LOC103377018BAR domain-containing protein. (407 aa)
LOC103395882Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (734 aa)
LOC103395203Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (508 aa)
rrasRAS related. (197 aa)
akt1s1AKT1 substrate 1 (proline-rich). (356 aa)
LOC103397133Uncharacterized protein; Belongs to the peptidase C1 family. (336 aa)
pdpk13-phosphoinositide dependent protein kinase 1b. (565 aa)
hmgb1High mobility group box 1a. (205 aa)
LOC103379409Cathepsin Ba; Belongs to the peptidase C1 family. (332 aa)
uvragUV radiation resistance associated gene. (739 aa)
atg101Autophagy related 101. (218 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
LOC103397431Myotubularin related protein 3. (1245 aa)
wdr41WD repeat domain 41. (450 aa)
LOC103397425Vesicle-associated membrane protein 8 (endobrevin). (122 aa)
LOC103392975Zgc:55558. (187 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (726 aa)
LOC103389765Insulin receptor substrate 2a. (1053 aa)
LOC103395326Ras-related GTP binding A. (315 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (436 aa)
LOC103378286Zgc:171927. (213 aa)
dapk3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (464 aa)
LOC103384255Uncharacterized protein. (243 aa)
LOC103393011Endoplasmic reticulum to nucleus signaling 1. (1036 aa)
LOC103390073Non-specific serine/threonine protein kinase. (574 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1120 aa)
LOC103391208Serine/threonine-protein phosphatase. (309 aa)
rubcnRubicon autophagy regulator. (976 aa)
bnip3BCL2 interacting protein 3. (190 aa)
LOC103396481RAB8A, member RAS oncogene family. (234 aa)
LOC103394768Uncharacterized protein. (410 aa)
LOC103387686Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (457 aa)
LOC103378401WD_REPEATS_REGION domain-containing protein. (598 aa)
rhebRas homolog, mTORC1 binding. (184 aa)
badBCL2 associated agonist of cell death b. (178 aa)
LOC103396148Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
ddit4DNA-damage-inducible transcript 4. (226 aa)
ENSCSEP00000026957Uncharacterized protein. (2532 aa)
ENSCSEP00000026996Si:ch211-284e13.4. (1117 aa)
LOC103393219Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (405 aa)
mtmr14Myotubularin related protein 14. (650 aa)
rab39bUncharacterized protein. (213 aa)
atg4cCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (473 aa)
bcl2BCL2 apoptosis regulator b. (237 aa)
map3k7Mitogen-activated protein kinase kinase kinase 7. (603 aa)
Atg12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (131 aa)
LOC103390257Mitogen-activated protein kinase. (380 aa)
mrasMuscle RAS oncogene homolog. (208 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC103397828Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Supt20hSPT20 homolog, SAGA complex component. (834 aa)
LOC103380759Zinc finger, FYVE domain containing 1. (780 aa)
LOC103388004Zgc:92606. (117 aa)
catlUncharacterized protein; Belongs to the peptidase C1 family. (336 aa)
dapk1Death-associated protein kinase 1. (1446 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAB39BRAB39B, member RAS oncogene family. (213 aa)
RAB8ARAB8A, member RAS oncogene family. (116 aa)
snap29Synaptosome associated protein 29. (262 aa)
rragcRas-related GTP binding Ca. (383 aa)
mapk8Mitogen-activated protein kinase. (383 aa)
LOC103391449RAB33B, member RAS oncogene family a. (233 aa)
LOC103380823Cathepsin Bb; Belongs to the peptidase C1 family. (328 aa)
igbp1Immunoglobulin (CD79A) binding protein 1. (340 aa)
LOC103383287RAB1A, member RAS oncogene family a. (205 aa)
Atg10ATG10 autophagy related 10 homolog (S. cerevisiae). (228 aa)
Atg7ATG7 autophagy related 7 homolog (S. cerevisiae). (723 aa)
LOC103379687GABA(A) receptor-associated protein like 2. (143 aa)
ambra1Autophagy/beclin-1 regulator 1b. (1417 aa)
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
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