STRINGSTRING
LOC103377950 LOC103377950 LOC103385960 LOC103385960 ppp3r1 ppp3r1 RAC1 RAC1 WNT2B WNT2B lgr4 lgr4 CCND1 CCND1 LOC103383441 LOC103383441 LOC103389353 LOC103389353 LOC103385834 LOC103385834 ppard ppard PLCB4 PLCB4 PLCB1 PLCB1 LOC103385889 LOC103385889 LOC112487879 LOC112487879 tp53 tp53 dkk2 dkk2 LOC103384668 LOC103384668 cxxc4 cxxc4 LOC103378445 LOC103378445 ruvbl1 ruvbl1 nlk nlk ryk ryk fzd5 fzd5 wnt16 wnt16 ctnnb1 ctnnb1 lrp6 lrp6 LOC103384774 LOC103384774 sfrp2 sfrp2 PRICKLE1 PRICKLE1 LOC103384870 LOC103384870 nkd2 nkd2 LOC103384848 LOC103384848 wnt8b wnt8b LOC103388894 LOC103388894 LOC103389499 LOC103389499 prickle2 prickle2 LOC103378870 LOC103378870 LOC103385009 LOC103385009 LOC103385014 LOC103385014 LOC103382638 LOC103382638 ctnnbip1 ctnnbip1 LOC103390898 LOC103390898 sfrp5 sfrp5 rbx1 rbx1 LOC103397887 LOC103397887 csnk1e csnk1e LOC107988365 LOC107988365 LOC103382708 LOC103382708 LOC103380246 LOC103380246 LOC103380252 LOC103380252 wnt1 wnt1 wnt10b wnt10b LOC103387363 LOC103387363 LOC103388495 LOC103388495 LOC103388489 LOC103388489 tcf7l2 tcf7l2 LOC103396896 LOC103396896 wnt4 wnt4 Jun Jun LOC103397348 LOC103397348 ccn4 ccn4 LOC103394609 LOC103394609 camk2b camk2b ENSCSEP00000013284 ENSCSEP00000013284 LOC103376912 LOC103376912 LOC103381519 LOC103381519 wnt5b wnt5b LOC103388659 LOC103388659 prkacb prkacb rspo3 rspo3 LOC103380318 LOC103380318 rspo2 rspo2 LOC103395725 LOC103395725 LOC103392719 LOC103392719 PPP3CA PPP3CA LOC103393969 LOC103393969 LOC103392009 LOC103392009 LOC103381643 LOC103381643 ror2 ror2 lef1 lef1 prkca prkca prickle1 prickle1 LOC103393459 LOC103393459 CTBP2 CTBP2 LOC103392073 LOC103392073 rnf43 rnf43 fzd3 fzd3 LOC103396312 LOC103396312 LOC103391026 LOC103391026 LOC103381664 LOC103381664 LOC103394065 LOC103394065 notum notum nkd1 nkd1 gsk3b gsk3b LOC103382897 LOC103382897 LOC103384064 LOC103384064 nfatc3 nfatc3 LOC103391014 LOC103391014 ENSCSEP00000018661 ENSCSEP00000018661 wnt3a wnt3a wnt9a wnt9a LOC103379080 LOC103379080 SMAD3 SMAD3 wnt11 wnt11 fzd6 fzd6 LOC103384177 LOC103384177 LOC103397412 LOC103397412 LOC103392299 LOC103392299 ENSCSEP00000021575 ENSCSEP00000021575 VANGL1 VANGL1 CSNK2A2 CSNK2A2 LOC103377099 LOC103377099 LOC103393020 LOC103393020 LOC103393014 LOC103393014 nfatc2 nfatc2 AXIN2 AXIN2 ENSCSEP00000023422 ENSCSEP00000023422 sost sost skp1 skp1 ENSCSEP00000023957 ENSCSEP00000023957 LOC103394304 LOC103394304 LOC103386563 LOC103386563 LOC103387658 LOC103387658 Fzd10 Fzd10 cul1 cul1 ENSCSEP00000025327 ENSCSEP00000025327 LOC103387688 LOC103387688 cacybp cacybp ENSCSEP00000025909 ENSCSEP00000025909 SMAD4 SMAD4 ENSCSEP00000026745 ENSCSEP00000026745 LOC103391285 LOC103391285 ENSCSEP00000026796 ENSCSEP00000026796 LOC112486245 LOC112486245 fzd2 fzd2 LOC103394421 LOC103394421 ror1 ror1 map3k7 map3k7 Plcb3 Plcb3 ENSCSEP00000028619 ENSCSEP00000028619 fzd4 fzd4 LOC103390257 LOC103390257 ENSCSEP00000029394 ENSCSEP00000029394 LOC103386704 LOC103386704 LOC103378548 LOC103378548 Fzd9 Fzd9 dvl1 dvl1 LOC103392496 LOC103392496 LOC103382085 LOC103382085 cby1 cby1 LOC103386737 LOC103386737 ENSCSEP00000031071 ENSCSEP00000031071 LOC103386756 LOC103386756 ENSCSEP00000031194 ENSCSEP00000031194 porcn porcn ENSCSEP00000031320 ENSCSEP00000031320 LOC103391414 LOC103391414 rspo1 rspo1 mapk8 mapk8 Apc Apc daam1 daam1 EP300 EP300 csnk1a1 csnk1a1 LOC103392544 LOC103392544 LOC103395641 LOC103395641 LOC103397863 LOC103397863 LOC103379514 LOC103379514 chd8 chd8 axin1 axin1 wnt9b wnt9b LOC103396670 LOC103396670 VANGL2 VANGL2 Wnt2 Wnt2 wnt7a wnt7a siah1 siah1 LOC103379657 LOC103379657 ENSCSEP00000033817 ENSCSEP00000033817
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103377950Dishevelled associated activator of morphogenesis 2. (1074 aa)
LOC103385960Vang-like protein. (528 aa)
ppp3r1Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
RAC1Rac family small GTPase 1. (192 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
lgr4Leucine-rich repeat containing G protein-coupled receptor 4. (986 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (293 aa)
LOC103383441Rac family small GTPase 2. (192 aa)
LOC103389353HMG box domain-containing protein. (569 aa)
LOC103385834Uncharacterized protein. (193 aa)
ppardPeroxisome proliferator-activated receptor delta b. (507 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1238 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1111 aa)
LOC103385889Cyclin D3; Belongs to the cyclin family. (351 aa)
LOC112487879CaMKII_AD domain-containing protein. (153 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (377 aa)
dkk2Dickkopf WNT signaling pathway inhibitor 2. (245 aa)
LOC103384668Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (437 aa)
cxxc4CXXC finger 4. (289 aa)
LOC103378445SUMO specific peptidase 2. (601 aa)
ruvbl1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
nlkMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (551 aa)
rykReceptor like tyrosine kinase. (631 aa)
fzd5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ctnnb1Catenin (cadherin-associated protein), beta 1. (781 aa)
lrp6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1621 aa)
LOC103384774HMG box domain-containing protein. (296 aa)
sfrp2Secreted frizzled-related protein 2. (295 aa)
PRICKLE1Prickle homolog 1a. (855 aa)
LOC103384870Ras homolog gene family, member Aa. (193 aa)
nkd2NKD inhibitor of WNT signaling pathway 2a. (460 aa)
LOC103384848Porcupine O-acyltransferase like; Belongs to the membrane-bound acyltransferase family. (450 aa)
wnt8bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (397 aa)
LOC103388894Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1. (513 aa)
LOC103389499Dickkopf_N domain-containing protein. (382 aa)
prickle2Prickle homolog 2b. (926 aa)
LOC103378870Casein kinase 2, alpha prime polypeptide a; Belongs to the protein kinase superfamily. (322 aa)
LOC103385009Uncharacterized protein. (239 aa)
LOC103385014HMG box domain-containing protein. (332 aa)
LOC103382638Uncharacterized protein. (622 aa)
ctnnbip1Catenin, beta interacting protein 1. (81 aa)
LOC103390898F-box and WD repeat domain containing 11a. (562 aa)
sfrp5Secreted frizzled-related protein 5. (319 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
LOC103397887Mothers against decapentaplegic homolog. (510 aa)
csnk1eProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (414 aa)
LOC107988365HMG box domain-containing protein. (167 aa)
LOC103382708Cyclin D2, b; Belongs to the cyclin family. (309 aa)
LOC103380246Mothers against decapentaplegic homolog. (425 aa)
LOC103380252TLE family member 3, transcriptional corepressor. (769 aa)
wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (428 aa)
LOC103387363Mitogen-activated protein kinase. (438 aa)
LOC103388495Zgc:86598; Belongs to the protein kinase superfamily. (392 aa)
LOC103388489Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
tcf7l2Transcription factor 7 like 2. (635 aa)
LOC103396896RING-type domain-containing protein. (872 aa)
wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
JunJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (303 aa)
LOC103397348Transcription factor 7 like 1b. (623 aa)
ccn4Cellular communication network factor 4a. (363 aa)
LOC103394609Uncharacterized protein. (757 aa)
camk2bCalcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2. (539 aa)
ENSCSEP00000013284Uncharacterized protein. (515 aa)
LOC103376912Catenin (cadherin-associated protein), delta 2a. (1260 aa)
LOC103381519Protein kinase domain-containing protein. (616 aa)
wnt5bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (436 aa)
LOC103388659RHD domain-containing protein. (938 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
rspo3R-spondin 3. (330 aa)
LOC103380318Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
rspo2R-spondin2. (244 aa)
LOC103395725Serine/threonine-protein phosphatase. (514 aa)
LOC103392719Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (452 aa)
PPP3CASerine/threonine-protein phosphatase. (523 aa)
LOC103393969Nuclear factor of activated T cells 1. (848 aa)
LOC103392009Transducin beta like 1 X-linked. (513 aa)
LOC103381643Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (486 aa)
ror2Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1065 aa)
lef1Lymphoid enhancer-binding factor 1. (361 aa)
prkcaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
prickle1Uncharacterized protein. (955 aa)
LOC103393459Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (475 aa)
CTBP2C-terminal binding protein 2; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (445 aa)
LOC103392073Vang-like protein. (540 aa)
rnf43RING-type domain-containing protein. (829 aa)
fzd3Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family. (693 aa)
LOC103396312Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
LOC103391026Mitogen-activated protein kinase. (389 aa)
LOC103381664Rac family small GTPase 3b. (209 aa)
LOC103394065Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
notumNotum, palmitoleoyl-protein carboxylesterase a. (497 aa)
nkd1NKD inhibitor of WNT signaling pathway 1. (448 aa)
gsk3bGlycogen synthase kinase 3 beta, genome duplicate b. (474 aa)
LOC103382897Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
LOC103384064Notum pectinacetylesterase 2. (578 aa)
nfatc3Nuclear factor of activated T cells 3a. (1118 aa)
LOC103391014C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (447 aa)
ENSCSEP00000018661Uncharacterized protein. (125 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
wnt9aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
LOC103379080Cyclin D1; Belongs to the cyclin family. (293 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
fzd6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (693 aa)
LOC103384177DAN domain family, member 5. (260 aa)
LOC103397412Secreted frizzled-related protein 1a. (299 aa)
LOC103392299Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (566 aa)
ENSCSEP00000021575Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (529 aa)
VANGL1Vang-like protein. (503 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
LOC103377099BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
LOC103393020Uncharacterized protein. (192 aa)
LOC103393014Axin 2 (conductin, axil). (839 aa)
nfatc2Nuclear factor of activated T cells 2a. (949 aa)
AXIN2Axin 2. (792 aa)
ENSCSEP00000023422Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
sostSclerostin. (220 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (193 aa)
ENSCSEP00000023957R-spondin 4. (209 aa)
LOC103394304Mothers against decapentaplegic homolog. (573 aa)
LOC103386563Ras homolog family member Ca. (193 aa)
LOC103387658C-terminal binding protein 2. (716 aa)
Fzd10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
cul1Cullin 1b; Belongs to the cullin family. (766 aa)
ENSCSEP00000025327Rho-associated, coiled-coil containing protein kinase 2a; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1413 aa)
LOC103387688Dickkopf WNT signaling pathway inhibitor 1a. (253 aa)
cacybpCalcyclin binding protein. (227 aa)
ENSCSEP00000025909BZIP domain-containing protein; Belongs to the bZIP family. (326 aa)
SMAD4Mothers against decapentaplegic homolog. (503 aa)
ENSCSEP00000026745Serine/threonine-protein phosphatase. (480 aa)
LOC103391285Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
ENSCSEP00000026796Transducin (beta)-like 1 X-linked receptor 1b. (515 aa)
LOC112486245Phosphoinositide phospholipase C. (935 aa)
fzd2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (546 aa)
LOC103394421Uncharacterized protein. (320 aa)
ror1Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (960 aa)
map3k7Mitogen-activated protein kinase kinase kinase 7. (603 aa)
Plcb3Phosphoinositide phospholipase C. (799 aa)
ENSCSEP00000028619G_PROTEIN_RECEP_F1_2 domain-containing protein. (792 aa)
fzd4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (533 aa)
LOC103390257Mitogen-activated protein kinase. (380 aa)
ENSCSEP00000029394Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (705 aa)
LOC103386704Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
LOC103378548Uncharacterized protein. (343 aa)
Fzd9Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
dvl1Dishevelled segment polarity protein 1a. (728 aa)
LOC103392496Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
LOC103382085Casein kinase 1, epsilon; Belongs to the protein kinase superfamily. (421 aa)
cby1Chibby homolog 1 (Drosophila). (135 aa)
LOC103386737RHD domain-containing protein. (695 aa)
ENSCSEP00000031071MYC proto-oncogene, bHLH transcription factor a. (436 aa)
LOC103386756Myelocytomatosis oncogene homolog. (380 aa)
ENSCSEP00000031194Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
porcnPorcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (445 aa)
ENSCSEP00000031320Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
LOC103391414Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
rspo1R-spondin1 protein. (277 aa)
mapk8Mitogen-activated protein kinase. (383 aa)
ApcAPC_N_CC domain-containing protein. (270 aa)
daam1Dishevelled associated activator of morphogenesis 1b. (1101 aa)
EP300E1A binding protein p300. (2880 aa)
csnk1a1Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (353 aa)
LOC103392544Cyclin Dx; Belongs to the cyclin family. (340 aa)
LOC103395641SERPIN domain-containing protein; Belongs to the serpin family. (406 aa)
LOC103397863Zinc and ring finger 3. (894 aa)
LOC103379514Low density lipoprotein receptor-related protein 5. (1626 aa)
chd8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2592 aa)
axin1Axin 1. (810 aa)
wnt9bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LOC103396670Catenin (cadherin-associated protein), delta 2b. (1191 aa)
VANGL2Vang-like protein. (525 aa)
Wnt2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
wnt7aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
siah1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (344 aa)
LOC103379657Cyclin D2, a; Belongs to the cyclin family. (297 aa)
ENSCSEP00000033817Nuclear factor of activated T cells 3b. (899 aa)
Your Current Organism:
Cynoglossus semilaevis
NCBI taxonomy Id: 244447
Other names: C. semilaevis, Cynoglossus (Arelia) semilaevis, half-smooth tongue sole, tongue sole
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