(12 nodes) DNA replication network (Carboxydothermus hydrogenoformans)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Your Input:
	CHY_0036	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (143 aa)
	dnaB	Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (443 aa)
	CHY_0051	Putative DNA polymerase III, delta prime subunit; Identified by similarity to SP:P37540. (267 aa)
	CHY_0405	Conserved hypothetical protein; Identified by similarity to GB:AAO82164.1; match to protein family HMM PF06144; match to protein family HMM TIGR01128. (327 aa)
	rnhA	Ribonuclease HI; Identified by match to protein family HMM PF00075. (148 aa)
	dnaE1	DNA polymerase III, alpha subunit; Identified by similarity to SP:O34623; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. (964 aa)
	dnaE2	DNA polymerase III, alpha subunit; Identified by similarity to SP:O34623; match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. (1116 aa)
	polC	DNA polymerase III, alpha subunit, Gram-positive type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1407 aa)
	topA	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (694 aa)
	CHY_2640	DNA primase, internal deletion; Identified by similarity to SP:P05096; match to protein family HMM PF01751. (425 aa)
	dnaX	Putative DNA polymerase III, gamma/tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (511 aa)
	dnaN	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (371 aa)

Your Current Organism:

Carboxydothermus hydrogenoformans

NCBI taxonomy Id: 246194
Other names: C. hydrogenoformans Z-2901, Carboxydothermus hydrogenoformans Z-2901, Carboxydothermus hydrogenoformans str. Z-2901

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHY_0036	dnaB	CHY_0036	CHY_0041	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.	0.830
CHY_0036	dnaE1	CHY_0036	CHY_0959	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	DNA polymerase III, alpha subunit; Identified by similarity to SP:O34623; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594.	0.856
CHY_0036	dnaE2	CHY_0036	CHY_1137	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	DNA polymerase III, alpha subunit; Identified by similarity to SP:O34623; match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594.	0.832
CHY_0036	dnaN	CHY_0036	CHY_2709	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.441
CHY_0036	dnaX	CHY_0036	CHY_2675	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	Putative DNA polymerase III, gamma/tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.943
CHY_0036	rnhA	CHY_0036	CHY_0852	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	Ribonuclease HI; Identified by match to protein family HMM PF00075.	0.767
CHY_0036	topA	CHY_0036	CHY_1794	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.995
CHY_0051	CHY_0405	CHY_0051	CHY_0405	Putative DNA polymerase III, delta prime subunit; Identified by similarity to SP:P37540.	Conserved hypothetical protein; Identified by similarity to GB:AAO82164.1; match to protein family HMM PF06144; match to protein family HMM TIGR01128.	0.994
CHY_0051	dnaE1	CHY_0051	CHY_0959	Putative DNA polymerase III, delta prime subunit; Identified by similarity to SP:P37540.	DNA polymerase III, alpha subunit; Identified by similarity to SP:O34623; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594.	0.988
CHY_0051	dnaE2	CHY_0051	CHY_1137	Putative DNA polymerase III, delta prime subunit; Identified by similarity to SP:P37540.	DNA polymerase III, alpha subunit; Identified by similarity to SP:O34623; match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594.	0.986
CHY_0051	dnaN	CHY_0051	CHY_2709	Putative DNA polymerase III, delta prime subunit; Identified by similarity to SP:P37540.	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.999
CHY_0051	dnaX	CHY_0051	CHY_2675	Putative DNA polymerase III, delta prime subunit; Identified by similarity to SP:P37540.	Putative DNA polymerase III, gamma/tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.995
CHY_0051	polC	CHY_0051	CHY_1772	Putative DNA polymerase III, delta prime subunit; Identified by similarity to SP:P37540.	DNA polymerase III, alpha subunit, Gram-positive type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.911
CHY_0051	topA	CHY_0051	CHY_1794	Putative DNA polymerase III, delta prime subunit; Identified by similarity to SP:P37540.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.766
CHY_0405	CHY_0051	CHY_0405	CHY_0051	Conserved hypothetical protein; Identified by similarity to GB:AAO82164.1; match to protein family HMM PF06144; match to protein family HMM TIGR01128.	Putative DNA polymerase III, delta prime subunit; Identified by similarity to SP:P37540.	0.994
CHY_0405	dnaB	CHY_0405	CHY_0041	Conserved hypothetical protein; Identified by similarity to GB:AAO82164.1; match to protein family HMM PF06144; match to protein family HMM TIGR01128.	Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.	0.493
CHY_0405	dnaE1	CHY_0405	CHY_0959	Conserved hypothetical protein; Identified by similarity to GB:AAO82164.1; match to protein family HMM PF06144; match to protein family HMM TIGR01128.	DNA polymerase III, alpha subunit; Identified by similarity to SP:O34623; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594.	0.984
CHY_0405	dnaE2	CHY_0405	CHY_1137	Conserved hypothetical protein; Identified by similarity to GB:AAO82164.1; match to protein family HMM PF06144; match to protein family HMM TIGR01128.	DNA polymerase III, alpha subunit; Identified by similarity to SP:O34623; match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594.	0.984
CHY_0405	dnaN	CHY_0405	CHY_2709	Conserved hypothetical protein; Identified by similarity to GB:AAO82164.1; match to protein family HMM PF06144; match to protein family HMM TIGR01128.	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.995
CHY_0405	dnaX	CHY_0405	CHY_2675	Conserved hypothetical protein; Identified by similarity to GB:AAO82164.1; match to protein family HMM PF06144; match to protein family HMM TIGR01128.	Putative DNA polymerase III, gamma/tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.994