STRINGSTRING
cwsA cwsA crgA crgA pknB pknB pknA pknA pbpA pbpA ABK71056.1 ABK71056.1 ABK72306.1 ABK72306.1 fhaB fhaB murB murB ABK70020.1 ABK70020.1 alr alr ABK75945.1 ABK75945.1 ddl ddl ABK76053.1 ABK76053.1 ripA ripA garA garA wag31 wag31 ABK76142.1 ABK76142.1 sepF sepF ABK72274.1 ABK72274.1 ABK69811.1 ABK69811.1 ftsZ ftsZ ABK73546.1 ABK73546.1 ftsQ ftsQ murC murC murG murG ftsW ftsW murD murD mraY mraY murF murF murE murE pbpB pbpB ABK72118.1 ABK72118.1 mraW mraW mraZ mraZ ABK75301.1 ABK75301.1 ABK74362.1 ABK74362.1 ABK71684.1 ABK71684.1 ABK76060.1 ABK76060.1 ABK73137.1 ABK73137.1 ABK72295.1 ABK72295.1 murA murA ABK72792.1 ABK72792.1 ABK70790.1 ABK70790.1 ABK74946.1 ABK74946.1 ABK75989.1 ABK75989.1 ABK71221.1 ABK71221.1 ABK71860.1 ABK71860.1 ABK72238.1 ABK72238.1 ABK75413.1 ABK75413.1 ponA1 ponA1 ABK72323.1 ABK72323.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cwsAConserved hypothetical protein; Required for regulated cell division, cell wall synthesis and the maintenance of cell shape; Belongs to the CwsA family. (136 aa)
crgAPutative membrane protein; Involved in cell division; Belongs to the CrgA family. (94 aa)
pknBSerine-threonine protein kinase; Protein kinase that regulates many aspects of mycobacterial physiology. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins (By similarity). Probably phosphorylates RseA. (625 aa)
pknASerine/threonine protein kinase PknA; Identified by match to protein family HMM PF00069. (419 aa)
pbpAPenicillin binding protein transpeptidase domain protein; Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation. (491 aa)
ABK71056.1Cell cycle protein, FtsW/RodA/SpoVE family protein; Identified by match to protein family HMM PF01098; Belongs to the SEDS family. (471 aa)
ABK72306.1Protein phosphatase 2C; Identified by match to protein family HMM PF00481. (512 aa)
fhaBFHA domain protein; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. (155 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (363 aa)
ABK70020.1Serine/threonine-protein kinase PknD; Identified by match to protein family HMM PF00069; match to protein family HMM PF00497. (608 aa)
alrAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (389 aa)
ABK75945.1Identified by match to protein family HMM PF00481. (233 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation. (373 aa)
ABK76053.1Penicillin-binding protein, putative; Identified by match to protein family HMM PF00905; match to protein family HMM PF05223. (606 aa)
ripASecreted cell wall-associated hydrolase; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan. Required for normal separation of daughter cells after cell division and for cell wall integrity (By similarity). (497 aa)
garAForkhead-associated protein; Involved in regulation of glutamate metabolism. Acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd and Gdh. (143 aa)
wag31DivIVA protein; Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles. Protects PbpB (PBP3, FtsI) from oxidative stress-induced cleavage. Belongs to the DivIVA family. (272 aa)
ABK76142.1Possible conserved transmembrane protein. (96 aa)
sepFConserved hypothetical protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (214 aa)
ABK72274.1Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. (291 aa)
ABK69811.1Conserved hypothetical protein; Identified by match to protein family HMM PF02578; match to protein family HMM TIGR00726; Belongs to the multicopper oxidase YfiH/RL5 family. (237 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (385 aa)
ABK73546.1Hypothetical protein; Identified by Glimmer2; putative. (42 aa)
ftsQPutative Cell division protein FtsQ; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily. (333 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (482 aa)
murGUndecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (385 aa)
ftsWCell division protein FtsW; Identified by match to protein family HMM PF01098; match to protein family HMM TIGR02614; Belongs to the SEDS family. (568 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (493 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (359 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (509 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (520 aa)
pbpBPenicillin binding protein transpeptidase domain protein; Identified by match to protein family HMM PF00905; match to protein family HMM PF03717; Belongs to the transpeptidase family. (648 aa)
ABK72118.1Conserved hypothetical protein. (380 aa)
mraWS-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (326 aa)
mraZMraZ protein; Identified by match to protein family HMM PF02381; match to protein family HMM TIGR00242; Belongs to the MraZ family. (143 aa)
ABK75301.1Transcriptional regulatory protein. (134 aa)
ABK74362.1Serine/threonine-protein kinase PK-1; Identified by match to protein family HMM PF00069; match to protein family HMM PF01163. (422 aa)
ABK71684.1Serine/threonine-protein kinase PknD; Identified by match to protein family HMM PF00069. (525 aa)
ABK76060.1Penicillin binding protein transpeptidase domain protein; Identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM PF03793. (803 aa)
ABK73137.1Resuscitation-promoting factor; Identified by match to protein family HMM PF06737. (107 aa)
ABK72295.1Identified by match to protein family HMM PF03734. (400 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (418 aa)
ABK72792.1Gp35 protein; Identified by match to protein family HMM PF01471; match to protein family HMM PF01510. (275 aa)
ABK70790.1Transglycosylase; Identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM PF03793. (788 aa)
ABK74946.1Serine/threonine protein kinase PksC; Identified by match to protein family HMM PF00069. (407 aa)
ABK75989.1Mur ligase family protein. (407 aa)
ABK71221.1Cobyric acid synthase; Identified by match to protein family HMM PF07685. (239 aa)
ABK71860.1N-acetylmuramoyl-L-alanine amidase; Identified by match to protein family HMM PF01520. (264 aa)
ABK72238.1Penicillin-binding protein, transpeptidase; Identified by match to protein family HMM PF00905; match to protein family HMM PF05223. (592 aa)
ABK75413.1N-acetylmuramoyl-L-alanine amidase; Identified by match to protein family HMM PF01510. (536 aa)
ponA1Penicillin-binding protein 1; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits) (By similarity). (785 aa)
ABK72323.1N-acetylmuramoyl-L-alanine amidase; Identified by match to protein family HMM PF01471; match to protein family HMM PF01520. (396 aa)
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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