STRINGSTRING
bfr bfr ABK75926.1 ABK75926.1 ABK70024.1 ABK70024.1 ABK71342.1 ABK71342.1 ABK76071.1 ABK76071.1 ABK73660.1 ABK73660.1 ABK69805.1 ABK69805.1 ABK72515.1 ABK72515.1 ABK76088.1 ABK76088.1 ABK74294.1 ABK74294.1 ABK70714.1 ABK70714.1 ABK70154.1 ABK70154.1 ABK70147.1 ABK70147.1 ABK71984.1 ABK71984.1 ABK73820.1 ABK73820.1 ABK74247.1 ABK74247.1 ABK76221.1 ABK76221.1 ABK69642.1 ABK69642.1 ABK73406.1 ABK73406.1 ABK74416.1 ABK74416.1 ABK70910.1 ABK70910.1 hutI hutI ABK70182.1 ABK70182.1 ABK72488.1 ABK72488.1 ABK72572.1 ABK72572.1 ABK74703.1 ABK74703.1 ABK70678.1 ABK70678.1 tsaD tsaD ABK75075.1 ABK75075.1 ABK72366.1 ABK72366.1 ABK75495.1 ABK75495.1 ABK74699.1 ABK74699.1 catA catA nuoI nuoI nuoB nuoB hmgA hmgA ABK70900.1 ABK70900.1 ABK72971.1 ABK72971.1 hypC hypC ABK71152.1 ABK71152.1 ABK74893.1 ABK74893.1 ABK74659.1 ABK74659.1 ABK76148.1 ABK76148.1 ABK71945.1 ABK71945.1 ABK75116.1 ABK75116.1 ABK71459.1 ABK71459.1 ABK71337.1 ABK71337.1 ispG ispG pcaH pcaH pcaG pcaG hypC-2 hypC-2 hypC-3 hypC-3 ABK70998.1 ABK70998.1 ABK71071.1 ABK71071.1 ABK73356.1 ABK73356.1 ABK70591.1 ABK70591.1 ABK71196.1 ABK71196.1 ABK73018.1 ABK73018.1 ABK71655.1 ABK71655.1 bioB bioB ABK69831.1 ABK69831.1 ABK74355.1 ABK74355.1 ABK71145.1 ABK71145.1 ABK69974.1 ABK69974.1 ABK72784.1 ABK72784.1 ABK70976.1 ABK70976.1 ABK74752.1 ABK74752.1 thpD thpD ABK75803.1 ABK75803.1 ABK69618.1 ABK69618.1 ABK74649.1 ABK74649.1 ABK74107.1 ABK74107.1 ABK72738.1 ABK72738.1 ABK72567.1 ABK72567.1 ABK75074.1 ABK75074.1 ABK71810.1 ABK71810.1 ABK73667.1 ABK73667.1 ABK70320.1 ABK70320.1 ABK69719.1 ABK69719.1 ABK72736.1 ABK72736.1 ABK71768.1 ABK71768.1 ABK70288.1 ABK70288.1 ABK71367.1 ABK71367.1 ABK73430.1 ABK73430.1 ABK75775.1 ABK75775.1 ABK71096.1 ABK71096.1 ABK75448.1 ABK75448.1 ABK73604.1 ABK73604.1 ABK69528.1 ABK69528.1 ABK72320.1 ABK72320.1 ABK72161.1 ABK72161.1 mhpB mhpB ABK75246.1 ABK75246.1 ABK72693.1 ABK72693.1 ABK71135.1 ABK71135.1 ABK70246.1 ABK70246.1 ABK75456.1 ABK75456.1 ABK73207.1 ABK73207.1 ABK71599.1 ABK71599.1 ABK75192.1 ABK75192.1 ABK72454.1 ABK72454.1 ABK73221.1 ABK73221.1 ABK72264.1 ABK72264.1 cyp142 cyp142 cyp125 cyp125 ABK73596.1 ABK73596.1 ABK73895.1 ABK73895.1 egtB egtB ABK70618.1 ABK70618.1 bfrB bfrB dps dps ABK70280.1 ABK70280.1 ABK76102.1 ABK76102.1 ABK71893.1 ABK71893.1 ABK72745.1 ABK72745.1 ABK70871.1 ABK70871.1 ABK75118.1 ABK75118.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bfrBacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. (161 aa)
ABK75926.1Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B; Identified by match to protein family HMM PF02900. (274 aa)
ABK70024.1C-5 sterol desaturase. (304 aa)
ABK71342.1Rieske [2Fe-2S] domain protein; Identified by match to protein family HMM PF00355. (421 aa)
ABK76071.1Amidohydrolase; Identified by match to protein family HMM PF01979; match to protein family HMM PF07969. (419 aa)
ABK73660.1Rieske [2Fe-2S] domain protein; Identified by match to protein family HMM PF00355. (421 aa)
ABK69805.1Oxidoreductase, 2OG-Fe(II) oxygenase family protein; Identified by match to protein family HMM PF03171; Belongs to the iron/ascorbate-dependent oxidoreductase family. (341 aa)
ABK72515.1Identified by match to protein family HMM PF00903. (199 aa)
ABK76088.1Rieske 2Fe-2S domain protein; Identified by match to protein family HMM PF00355. (394 aa)
ABK74294.1Putative cytochrome P450 144; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (405 aa)
ABK70714.1P450 heme-thiolate protein; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (422 aa)
ABK70154.1Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding; Identified by match to protein family HMM PF01315; match to protein family HMM PF02738. (704 aa)
ABK70147.1Carbon-monoxide dehydrogenase, large subunit; Identified by match to protein family HMM PF01315; match to protein family HMM PF02738; match to protein family HMM TIGR02416. (799 aa)
ABK71984.1Conserved domain protein. (64 aa)
ABK73820.1Cytochrome P450 FAS1; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (401 aa)
ABK74247.1Cytochrome P450; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (455 aa)
ABK76221.1Oxidoreductase; Identified by match to protein family HMM PF01315; match to protein family HMM PF02738. (721 aa)
ABK69642.1Cytochrome P450; Identified by match to protein family HMM PF00067. (484 aa)
ABK73406.1Cytochrome p450; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (494 aa)
ABK74416.1Hypothetical protein; Identified by Glimmer2; putative. (252 aa)
ABK70910.1Cytochrome P450; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (479 aa)
hutIImidazolonepropionase; Identified by similarity to SP:P42084; match to protein family HMM PF01979; match to protein family HMM PF07969; match to protein family HMM TIGR01224; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (396 aa)
ABK70182.1Cytochrome P450 monooxygenase; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (437 aa)
ABK72488.1Putative oxidoreductase; Identified by match to protein family HMM PF00111; match to protein family HMM PF01315; match to protein family HMM PF01799; match to protein family HMM PF02738. (893 aa)
ABK72572.1Oxidoreductase, 2OG-Fe(II) oxygenase family protein; Identified by match to protein family HMM PF03171; Belongs to the iron/ascorbate-dependent oxidoreductase family. (352 aa)
ABK74703.1Cytochrome P450-terp; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (416 aa)
ABK70678.1Cytochrome P450-terp; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (431 aa)
tsaDO-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (340 aa)
ABK75075.1Cytochrome P450 monooxygenase. (457 aa)
ABK72366.1Rubredoxin; Identified by match to protein family HMM PF00301; Belongs to the rubredoxin family. (57 aa)
ABK75495.1Rubredoxin; Identified by match to protein family HMM PF00301. (60 aa)
ABK74699.1Benzoate 1,2-dioxygenase alpha subunit; Identified by match to protein family HMM PF00355; match to protein family HMM PF00848. (454 aa)
catACatechol 1,2-dioxygenase; Identified by match to protein family HMM PF00775; match to protein family HMM PF04444; match to protein family HMM TIGR02438. (297 aa)
nuoINADH-quinone oxidoreductase, I subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (180 aa)
nuoBNADH-quinone oxidoreductase, B subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (184 aa)
hmgAHomogentisate 1,2-dioxygenase; Identified by match to protein family HMM PF04209. (367 aa)
ABK70900.1Cytochrome P450; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (402 aa)
ABK72971.1Cytochrome P450-terp; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (411 aa)
hypCHydrogenase assembly chaperone HypC/HupF; Identified by match to protein family HMM PF01455; match to protein family HMM TIGR00074. (86 aa)
ABK71152.1Cytochrome p450; Identified by match to protein family HMM PF00067. (494 aa)
ABK74893.1Methylesterase; Identified by match to protein family HMM PF00355. (338 aa)
ABK74659.1Carbon-monoxide dehydrogenase; Identified by match to protein family HMM PF01315; match to protein family HMM PF02738. (777 aa)
ABK76148.1Adenine deaminase; Identified by match to protein family HMM PF01979; match to protein family HMM PF07969. (406 aa)
ABK71945.1NikQ protein; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (418 aa)
ABK75116.1Conserved domain protein. (63 aa)
ABK71459.1Cytochrome P450 superfamily protein; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (412 aa)
ABK71337.1Oxidoreductase, 2OG-Fe(II) oxygenase family protein; Identified by match to protein family HMM PF03171; Belongs to the iron/ascorbate-dependent oxidoreductase family. (324 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (388 aa)
pcaHProtocatechuate 3,4-dioxygenase, beta subunit; Identified by match to protein family HMM PF00775; match to protein family HMM TIGR02422. (248 aa)
pcaGProtocatechuate 3,4-dioxygenase, alpha subunit; Identified by match to protein family HMM PF00775; match to protein family HMM TIGR02423. (185 aa)
hypC-2Hydrogenase assembly chaperone HypC/HupF; Identified by match to protein family HMM PF01455; match to protein family HMM TIGR00074. (94 aa)
hypC-3Hydrogenase assembly chaperone HypC/HupF; Identified by match to protein family HMM PF01455; match to protein family HMM TIGR00074. (86 aa)
ABK70998.1Iron-sulfur cluster-binding protein, Rieske family protein, putative; Identified by match to protein family HMM PF01106. (307 aa)
ABK71071.1Conserved hypothetical protein. (228 aa)
ABK73356.1C-5 sterol desaturase. (290 aa)
ABK70591.1Oxygenase KshA; Identified by match to protein family HMM PF00355. (386 aa)
ABK71196.1Carbon-monoxide dehydrogenase; Identified by match to protein family HMM PF01315; match to protein family HMM PF02738. (786 aa)
ABK73018.1SUF system FeS assembly protein, NifU family protein; Identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994. (164 aa)
ABK71655.1Cytochrome P450 107B1; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (421 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (353 aa)
ABK69831.1Starvation-inducible DNA-binding protein or fine tangled pili major subunit; Identified by match to protein family HMM PF00210; Belongs to the Dps family. (161 aa)
ABK74355.1Linalool 8-monooxygenase; Belongs to the cytochrome P450 family. (430 aa)
ABK71145.1Fatty acid hydroxylase; Identified by match to protein family HMM PF04116. (216 aa)
ABK69974.1Linalool 8-monooxygenase; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (425 aa)
ABK72784.1C-5 sterol desaturase. (307 aa)
ABK70976.1Cytochrome P450 monooxygenase; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (407 aa)
ABK74752.1Catalase; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. (359 aa)
thpDEctoine hydroxylase; Identified by match to protein family HMM PF05721; match to protein family HMM TIGR02408. (305 aa)
ABK75803.1Oxidoreductase, 2OG-Fe(II) oxygenase family protein; Identified by match to protein family HMM PF03171; Belongs to the iron/ascorbate-dependent oxidoreductase family. (329 aa)
ABK69618.1Oxidoreductase, 2OG-Fe(II) oxygenase family protein; Identified by match to protein family HMM PF03171; Belongs to the iron/ascorbate-dependent oxidoreductase family. (337 aa)
ABK74649.1Hydroxyquinol 1,2-dioxygenase; Identified by match to protein family HMM PF00775; match to protein family HMM PF04444. (294 aa)
ABK74107.1Conserved domain protein. (83 aa)
ABK72738.1Cytochrome P450. (152 aa)
ABK72567.1Cytochrome P450 hydroxylase; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (385 aa)
ABK75074.1Ubiquinol-cytochrome c reductase cytochrome c subunit; Identified by match to protein family HMM PF00034. (268 aa)
ABK71810.1Organophopsphate acid anhydrase; Identified by match to protein family HMM PF01979. (425 aa)
ABK73667.1Putative cytochrome P450 126; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (419 aa)
ABK70320.1phytanoyl-CoA dioxygenase; Identified by match to protein family HMM PF05721. (398 aa)
ABK69719.1Oxidoreductase; Identified by match to protein family HMM PF03171; Belongs to the iron/ascorbate-dependent oxidoreductase family. (319 aa)
ABK72736.1Cytochrome p450; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (437 aa)
ABK71768.1Conserved domain protein. (63 aa)
ABK70288.1Cytochrome P450 superfamily protein; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (453 aa)
ABK71367.1Conserved domain protein. (76 aa)
ABK73430.1Putative cytochrome P450 123; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (400 aa)
ABK75775.1Conserved domain protein. (66 aa)
ABK71096.1Conserved domain protein. (62 aa)
ABK75448.1Cytochrome p450; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (428 aa)
ABK73604.1Cytochrome P450; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (396 aa)
ABK69528.1Rieske [2Fe-2S] domain protein; Identified by match to protein family HMM PF00355. (447 aa)
ABK72320.1Cytochrome P450; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (410 aa)
ABK72161.1Conserved domain protein. (64 aa)
mhpBMetapyrocatechase 1; Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6- ketononatrienedioate, respectively; Belongs to the LigB/MhpB extradiol dioxygenase family. (306 aa)
ABK75246.1Cytochrome P450; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (400 aa)
ABK72693.1Putative cytochrome P450 123; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (406 aa)
ABK71135.1Cysteine dioxygenase type I superfamily protein; Identified by match to protein family HMM PF05995. (182 aa)
ABK70246.1Rieske [2Fe-2S] domain protein; Identified by match to protein family HMM PF00355. (462 aa)
ABK75456.1NikQ protein; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (401 aa)
ABK73207.1Cytochrome P450; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (411 aa)
ABK71599.1Cytochrome P450 109; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (400 aa)
ABK75192.1Cytochrome P450 51; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (451 aa)
ABK72454.1Cytochrome P450 51. (67 aa)
ABK73221.1Nicotine dehydrogenase; Identified by match to protein family HMM PF01315; match to protein family HMM PF02738. (784 aa)
ABK72264.1Conserved domain protein. (63 aa)
cyp142P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25R)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. (401 aa)
cyp125P450 heme-thiolate protein; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en- 3-one (aldehyde), to finally yield the carboxylic acid (25S)-3- oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one. (427 aa)
ABK73596.1Cytochrome p450; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (429 aa)
ABK73895.1Biphenyl-2,3-diol 1,2-dioxygenase; Identified by match to protein family HMM PF00903. (299 aa)
egtBConserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Cannot use the alternative thiols cysteine, N- acetylcysteine, or glutathione instead of gamma-glutamylcysteine as substrates, and histidine is a poor sulfur acceptor substrate compared to hercynine; Belongs to the EgtB family. (428 aa)
ABK70618.1Cytochrome P450 107B1; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (414 aa)
bfrBFerritin family protein; Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe(2+) ions into Fe(3+) ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex. (181 aa)
dpsStarvation-induced DNA protecting protein; Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). It protects DNA from hydroxyl radical-mediated cleavage. Binds DNA with no apparent sequence specificity without self- aggregation nor promotion of DNA condensation. Is unable to protect DNA from DNase-mediated cleavage (By similarity). (183 aa)
ABK70280.1Putative cytochrome P450 135B1; Identified by match to protein family HMM PF00067. (447 aa)
ABK76102.1Nicotinamidase/pyrazinamidase; Identified by match to protein family HMM PF00857. (183 aa)
ABK71893.1Cytochrome P450 monooxygenase; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (396 aa)
ABK72745.1Conserved domain protein. (62 aa)
ABK70871.1Cytochrome P450; Identified by match to protein family HMM PF00067; Belongs to the cytochrome P450 family. (400 aa)
ABK75118.1Hydroxyquinol 1,2-dioxygenase; Identified by match to protein family HMM PF00775; match to protein family HMM PF04444. (291 aa)
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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