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| | glgB | 1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. (736 aa) |
| | ABK72296.1 | Acyltransferase 3; Identified by match to protein family HMM PF01757. (711 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (608 aa) |
| | ABK75288.1 | Acyltransferase; Identified by match to protein family HMM PF01757. (397 aa) |
| | aftD | Conserved hypothetical protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG. (1414 aa) |
| | rfbA | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage; Belongs to the glucose-1-phosphate thymidylyltransferase family. (288 aa) |
| | ABK75432.1 | Putative acyltransferase; Identified by match to protein family HMM PF01757. (360 aa) |
| | ABK72163.1 | Nucleotide-sugar dehydrogenase; Identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (412 aa) |
| | ABK71325.1 | Glycosyl transferase, family protein 39; Identified by match to protein family HMM PF02366. (582 aa) |
| | ABK74535.1 | UDP-glucose 6-dehydrogenase; Identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026. (444 aa) |
| | ABK74282.1 | Conserved hypothetical protein. (187 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (247 aa) |
| | ABK73894.1 | Conserved hypothetical protein. (526 aa) |
| | ABK76007.1 | Gluconolactonase; Identified by match to protein family HMM PF03758. (375 aa) |
| | rmlC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (201 aa) |
| | rfbB | dTDP-glucose 4,6-dehydratase; Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6- deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction (By similarity). Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D- N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage. (331 aa) |
| | ABK71562.1 | Probable conserved transmembrane protein; Identified by match to protein family HMM PF04138. (223 aa) |
| | rfbD | dTDP-4-dehydrorhamnose reductase; Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage. Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L- rhamnose (By similarity); Belongs to the dTDP-4-dehydrorhamnose reductase family. (327 aa) |
| | ABK73213.1 | dTDP-RhA:a-D-GlcNAc-diphosphoryl polyprenol, a-3-L-rhamnosyl transferase; Identified by match to protein family HMM PF00535. (289 aa) |
| | ABK75917.1 | Conserved domain protein; Identified by match to protein family HMM PF00364. (73 aa) |
| | ABK72021.1 | Identified by match to protein family HMM PF00300. (203 aa) |
| | ABK70563.1 | Lipopolysaccharide biosynthesis acyltransferase, M; Identified by match to protein family HMM PF01757. (676 aa) |
| | ABK74062.1 | Conserved hypothetical protein. (526 aa) |
| | ABK71455.1 | Glycosyl hydrolase, family protein 57; Identified by match to protein family HMM PF03065; Belongs to the glycosyl hydrolase 57 family. (514 aa) |
| | DkgA | Morphine 6-dehydrogenase; Identified by match to protein family HMM PF00248; Belongs to the aldo/keto reductase family. (283 aa) |
| | ABK73906.1 | 2,5-diketo-D-gluconic acid reductase A; Identified by match to protein family HMM PF00248; Belongs to the aldo/keto reductase family. (275 aa) |
| | pyc | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1127 aa) |
| | ABK76121.1 | Gluconolactonase; Identified by match to protein family HMM PF03758. (294 aa) |
| | aftC | Putative conserved integral membrane protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG. (430 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa) |
| | ABK73947.1 | Conserved hypothetical protein; Catalyzes the addition of alpha-(1->6)-mannose residue. (559 aa) |
| | treZ | Malto-oligosyltrehalose trehalohydrolase; Identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02402. (583 aa) |
| | ABK73478.1 | Putative acyltransferase domain protein; Identified by match to protein family HMM PF01757. (719 aa) |
| | impA | Inositol monophosphate phosphatase; Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. (276 aa) |
| | ABK71245.1 | O-acyl transferase; Identified by match to protein family HMM PF01757. (375 aa) |
| | sdaA | L-serine ammonia-lyase; Identified by similarity to SP:P16095; match to protein family HMM PF03313; match to protein family HMM PF03315; match to protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa) |
| | ABK71169.1 | Putative membrane acyltransferase; Identified by match to protein family HMM PF01757. (404 aa) |
| | ABK73375.1 | Conserved hypothetical protein. (445 aa) |
| | ABK71786.1 | Conserved hypothetical protein. (442 aa) |
| | ABK73469.1 | Calcium-binding protein. (291 aa) |
| | ABK71371.1 | Conserved hypothetical protein. (181 aa) |
| | ABK74799.1 | Glycosyl transferase, group 2 family protein, putative; Identified by match to protein family HMM PF00535. (269 aa) |
| | glgE | Alpha-amylase family protein; Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is also able to catalyze the reverse reaction in vitro. Cannot use glucose 1-phosphate as substrate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB. (692 aa) |
| | wecA | Glycosyl trasferase; Involved in the biosynthesis of the disaccharide D-N- acetylglucosamine-L-rhamnose which plays an important role in the mycobacterial cell wall as a linker connecting arabinogalactan and peptidoglycan via a phosphodiester linkage. Catalyzes the transfer of the N-acetylglucosamine-1-phosphate (GlcNAc-1P) moiety from UDP-GlcNAc onto the carrier lipid decaprenyl phosphate (C50-P), yielding GlcNAc- pyrophosphoryl-decaprenyl (GlcNAc-PP-C50). (406 aa) |
| | ABK71228.1 | Glycosyl transferase, family protein 39; Identified by match to protein family HMM PF02366. (634 aa) |
| | ABK76211.1 | Glycosyl transferase; Identified by match to protein family HMM PF00535; match to protein family HMM PF04138. (432 aa) |
| | ABK69843.1 | Integral membrane protein; Identified by match to protein family HMM PF02366. (623 aa) |
| | ABK74336.1 | Probable acyltransferase; Identified by match to protein family HMM PF01757. (382 aa) |
| | glgC | Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose building block, required in the biosynthesis of maltose-1-phosphate (M1P) and in the elongation reactions to produce linear alpha-1,4-glucans. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. (404 aa) |
| | glgM | Glycogen synthase; Involved in the biosynthesis of the maltose-1-phosphate (M1P) building block required for alpha-glucan production by the key enzyme GlgE. Catalyzes the formation of an alpha-1,4 linkage between glucose from ADP-glucose and glucose 1-phosphate (G1P) to yield maltose-1- phosphate (M1P). (387 aa) |
| | ABK73118.1 | Conserved hypothetical protein. (437 aa) |
| | glpX | Fructose-1,6-bisphosphatase, class II; Identified by match to protein family HMM PF03320; match to protein family HMM TIGR00330. (342 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (482 aa) |
| | pgi | Glucose-6-phosphate isomerase; Identified by similarity to SP:P11537; match to protein family HMM PF00342; Belongs to the GPI family. (549 aa) |
| | otsA | Alpha,alpha-trehalose-phosphate synthase (UDP-forming); Involved in the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1- phosphate (M1P), and probably in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to glucose-6-phosphate (Glc-6-P) to form trehalose-6-phosphate. ADP-Glc, CDP-Glc, GDP- Glc and TDP-Glc are also glucosyl donors, however, when the pyrimidine sugar nucleotides (CDP-Glc, TDP-Glc and UDP-Glc) are used as substrates, there is an absolute requirement [...] (503 aa) |
| | ABK75801.1 | Cell surface polysaccharide biosynthesis, putative; Identified by match to protein family HMM PF02706. (211 aa) |
| | ABK74366.1 | Protein-tyrosine kinase, putative; Identified by match to protein family HMM PF02706. (221 aa) |
| | algD | GDP-mannose 6-dehydrogenase AlgD; Identified by similarity to SP:O07299; match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026. (496 aa) |
| | ABK69989.1 | Hypothetical protein; Identified by Glimmer2; putative. (246 aa) |
| | ABK75518.1 | Conserved hypothetical protein. (353 aa) |
| | ABK73096.1 | Glycosyl transferase, group 2 family protein, putative; Identified by match to protein family HMM PF00535. (313 aa) |
| | ABK72242.1 | Glycosyl transferase, family protein 2; Identified by match to protein family HMM PF00535. (695 aa) |
| | ABK72045.1 | Polysaccharide biosynthesis protein; Identified by match to protein family HMM PF01943. (510 aa) |
| | rfbC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (184 aa) |
| | ABK71549.1 | UDP-glucose 6-dehydrogenase; Identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026. (453 aa) |
| | rfbA-2 | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (292 aa) |
| | ABK74440.1 | Undecaprenyl-phosphate galactosephosphotransferase; Identified by match to protein family HMM PF02397; match to protein family HMM TIGR03025. (518 aa) |
| | otsB | Trehalose-phosphatase; Removes the phosphate from trehalose 6-phosphate to produce free trehalose. (249 aa) |
| | ABK71079.1 | Membrane protein. (426 aa) |
| | ABK73661.1 | Identified by match to protein family HMM PF00149. (328 aa) |
| | ABK75228.1 | Probable acyltransferase; Identified by match to protein family HMM PF01757. (383 aa) |
| | glfT1 | Glycosyl transferase, group 2 family protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the transfer of the first two galactofuranosyl (Galf) units from UDP- galactofuranose (UDP-Galf) onto the rhamnosyl-GlcNAc-diphospho- decaprenol (Rha-GlcNAc-PP-C50) acceptor, yielding galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50). Thus, GlfT1 is the initiator of galactan synthesis, while GlfT2 cont [...] (302 aa) |
| | ABK74530.1 | Identified by match to protein family HMM PF04138. (135 aa) |
| | ABK74552.1 | Senescence marker protein-30; Identified by match to protein family HMM PF03758. (300 aa) |
| | dprE1 | Oxidoreductase, FAD-binding; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'substrate chann [...] (468 aa) |
| | dprE2 | Putative oxidoreductase in MprA 5'region; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'su [...] (254 aa) |
| | aftA | Membrane protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases. It is not able to add an Araf residue to a terminal Galf. (624 aa) |
| | ABK75671.1 | Probable conserved transmembrane protein. (645 aa) |
| | ABK74962.1 | Prenyltransferase, UbiA family protein; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Catalyzes the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate (pRpp) to decaprenyl phosphate (DP) to form decaprenylphosphoryl-5-phosphoribose (DPPR). (318 aa) |
| | ABK71187.1 | PAP2 superfamily protein; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Could be involved in the dephosphorylation of decaprenylphosphoryl-5-phosphoribose (DPPR) to decaprenyl-phospho- ribose (DPR); Belongs to the PA-phosphatase related phosphoesterase family. (180 aa) |
| | glfT2 | Bifunctional udp-galactofuranosyl transferase glft; Involved in the galactan polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacteria cell wall. Thus, successively transfers approximately 28 galactofuranosyl (Galf) residues from UDP-galactofuranose (UDP-Galf) onto the galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50) acceptor produced by GlfT1, with alternating 1->5 and 1->6 links, forming a galactan domain with approximately 30 galactofu [...] (646 aa) |
| | glf | UDP-galactopyranose mutase; Identified by match to protein family HMM PF03275; match to protein family HMM TIGR00031. (412 aa) |
| | mak | Trehalose synthase-fused probable maltokinase; Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate (Probable). Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB. (441 aa) |
| | treS | Trehalose synthase; Catalyzes the reversible interconversion of maltose and trehalose by transglucosylation. Maltose is the preferred substrate. To a lesser extent, also displays amylase activity, catalyzing the endohydrolysis of (1->4)-alpha-D- glucosidic linkages in glycogen and maltooligosaccharides such as maltoheptaose, to produce maltose which then can be converted to trehalose. TreS plays a key role in the utilization of trehalose for the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1-phosphate (M1P). Might also functio [...] (593 aa) |
| | ABK70631.1 | Integral membrane protein; Identified by match to protein family HMM PF00149; match to protein family HMM TIGR01409. (388 aa) |
| | pyc-2 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1131 aa) |
| | ino1 | Myo-inositol-1-phosphate synthase; Catalyzes the conversion of glucose 6-phosphate to 1D-myo- inositol 3-phosphate; Belongs to the myo-inositol 1-phosphate synthase family. (363 aa) |
