STRINGSTRING
mraY mraY pbpA pbpA ABK71056.1 ABK71056.1 ABK76034.1 ABK76034.1 ABK74656.1 ABK74656.1 ABK70870.1 ABK70870.1 ABK75368.1 ABK75368.1 ABK76213.1 ABK76213.1 murB murB ABK70477.1 ABK70477.1 ABK73659.1 ABK73659.1 ABK73230.1 ABK73230.1 accD accD ddl ddl ABK73743.1 ABK73743.1 ABK71878.1 ABK71878.1 ABK70570.1 ABK70570.1 ABK73953.1 ABK73953.1 ABK73973.1 ABK73973.1 mltG mltG ripA ripA ABK75348.1 ABK75348.1 uppP uppP murC murC murG murG ftsW ftsW murD murD ABK75886.1 ABK75886.1 murF murF murE murE pbpB pbpB ABK72295.1 ABK72295.1 murI murI murA murA ABK75100.1 ABK75100.1 glmU glmU rpfB rpfB ABK70175.1 ABK70175.1 ponA1 ponA1 glfT2 glfT2 aftA aftA glfT1 glfT1 ABK71221.1 ABK71221.1 ABK75989.1 ABK75989.1 ABK69944.1 ABK69944.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (359 aa)
pbpAPenicillin binding protein transpeptidase domain protein; Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation. (491 aa)
ABK71056.1Cell cycle protein, FtsW/RodA/SpoVE family protein; Identified by match to protein family HMM PF01098; Belongs to the SEDS family. (471 aa)
ABK76034.1Lipoprotein Lpps; Identified by match to protein family HMM PF03734. (346 aa)
ABK74656.1Membrane protein, MmpL family protein. (1013 aa)
ABK70870.1Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039. (532 aa)
ABK75368.1Putative conserved exported protein. (208 aa)
ABK76213.1Identified by match to protein family HMM PF03734. (336 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (363 aa)
ABK70477.1Identified by match to protein family HMM PF03734. (452 aa)
ABK73659.1Identified by match to protein family HMM PF03734. (420 aa)
ABK73230.1D-alanyl-D-alanine carboxypeptidase; Identified by match to protein family HMM PF00768; Belongs to the peptidase S11 family. (397 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Identified by match to protein family HMM PF01039. (502 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation. (373 aa)
ABK73743.1D-alanyl-D-alanine carboxypeptidase; Identified by match to protein family HMM PF00768; Belongs to the peptidase S11 family. (275 aa)
ABK71878.1D-alanyl-D-alanine carboxypeptidase; Identified by match to protein family HMM PF00768; Belongs to the peptidase S11 family. (296 aa)
ABK70570.1Conserved hypothetical protein; Belongs to the UPF0109 family. (76 aa)
ABK73953.1LppW protein. (314 aa)
ABK73973.1Gnat-family protein acetyltransferase; Identified by match to protein family HMM PF00583; match to protein family HMM TIGR03103. (609 aa)
mltGConserved hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (414 aa)
ripASecreted cell wall-associated hydrolase; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan. Required for normal separation of daughter cells after cell division and for cell wall integrity (By similarity). (497 aa)
ABK75348.1Identified by match to protein family HMM PF03734. (259 aa)
uppPUndecaprenol kinase, putative; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (276 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (482 aa)
murGUndecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (385 aa)
ftsWCell division protein FtsW; Identified by match to protein family HMM PF01098; match to protein family HMM TIGR02614; Belongs to the SEDS family. (568 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (493 aa)
ABK75886.1acetyl-CoA carboxylase carboxyltransferase; Identified by match to protein family HMM PF01039. (531 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (509 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (520 aa)
pbpBPenicillin binding protein transpeptidase domain protein; Identified by match to protein family HMM PF00905; match to protein family HMM PF03717; Belongs to the transpeptidase family. (648 aa)
ABK72295.1Identified by match to protein family HMM PF03734. (400 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (277 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (418 aa)
ABK75100.1Integral membrane protein. (757 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (482 aa)
rpfBResuscitation-promoting factor RpfB; Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity (By similarity). Belongs to the transglycosylase family. Rpf subfamily. (375 aa)
ABK70175.1Integral membrane protein MviN, putative; Identified by match to protein family HMM PF03023; match to protein family HMM TIGR01695. (1216 aa)
ponA1Penicillin-binding protein 1; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits) (By similarity). (785 aa)
glfT2Bifunctional udp-galactofuranosyl transferase glft; Involved in the galactan polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacteria cell wall. Thus, successively transfers approximately 28 galactofuranosyl (Galf) residues from UDP-galactofuranose (UDP-Galf) onto the galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50) acceptor produced by GlfT1, with alternating 1->5 and 1->6 links, forming a galactan domain with approximately 30 galactofu [...] (646 aa)
aftAMembrane protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases. It is not able to add an Araf residue to a terminal Galf. (624 aa)
glfT1Glycosyl transferase, group 2 family protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the transfer of the first two galactofuranosyl (Galf) units from UDP- galactofuranose (UDP-Galf) onto the rhamnosyl-GlcNAc-diphospho- decaprenol (Rha-GlcNAc-PP-C50) acceptor, yielding galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50). Thus, GlfT1 is the initiator of galactan synthesis, while GlfT2 cont [...] (302 aa)
ABK71221.1Cobyric acid synthase; Identified by match to protein family HMM PF07685. (239 aa)
ABK75989.1Mur ligase family protein. (407 aa)
ABK69944.1Acetyl-coenzyme a carboxylase carboxyl transferase; Identified by match to protein family HMM PF01039. (489 aa)
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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