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| | ABK73618.1 | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (309 aa) |
| | ABK74280.1 | Hypothetical protein; Identified by Glimmer2; putative. (227 aa) |
| | ABK74318.1 | Identified by match to protein family HMM PF00756; match to protein family HMM PF01476. (450 aa) |
| | ABK75348.1 | Identified by match to protein family HMM PF03734. (259 aa) |
| | ABK70431.1 | Cytochrome C biogenesis protein transmembrane region; Identified by match to protein family HMM PF02683. (297 aa) |
| | glnA | Glutamine synthetase, catalytic domain; Identified by match to protein family HMM PF00120; Belongs to the glutamine synthetase family. (453 aa) |
| | ABK71197.1 | ATPase. (1068 aa) |
| | ABK69800.1 | Linear gramicidin synthetase subunit C; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR01720; match to protein family HMM TIGR01733; match to protein family HMM TIGR01746. (2574 aa) |
| | der | GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (471 aa) |
| | rluB | Ribosomal large subunit pseudouridine synthase B; Identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; Belongs to the pseudouridine synthase RsuA family. (247 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (158 aa) |
| | rplT | Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (129 aa) |
| | ABK71090.1 | Asp/Glu racemase; Identified by match to protein family HMM PF01177. (260 aa) |
| | ABK75557.1 | Conserved hypothetical protein. (317 aa) |
| | uppP | Undecaprenol kinase, putative; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (276 aa) |
| | sepF | Conserved hypothetical protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (214 aa) |
| | ftsZ | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (385 aa) |
| | ftsQ | Putative Cell division protein FtsQ; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily. (333 aa) |
| | murC | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (482 aa) |
| | murG | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (385 aa) |
| | ftsW | Cell division protein FtsW; Identified by match to protein family HMM PF01098; match to protein family HMM TIGR02614; Belongs to the SEDS family. (568 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (493 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (359 aa) |
| | murF | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (509 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (520 aa) |
| | pbpB | Penicillin binding protein transpeptidase domain protein; Identified by match to protein family HMM PF00905; match to protein family HMM PF03717; Belongs to the transpeptidase family. (648 aa) |
| | mraW | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (326 aa) |
| | ABK69803.1 | Identified by match to protein family HMM PF01521; match to protein family HMM TIGR00049; Belongs to the HesB/IscA family. (118 aa) |
| | ABK71606.1 | Conserved hypothetical protein. (183 aa) |
| | era | GTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (301 aa) |
| | ybeY | Conserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (178 aa) |
| | ABK70673.1 | Conserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (246 aa) |
| | ABK72785.1 | Linear gramicidin synthetase subunit B; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM TIGR01733. (1819 aa) |
| | ABK70717.1 | Polyketide synthase; Identified by match to protein family HMM PF00109; match to protein family HMM PF02801; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (433 aa) |
| | octT | Conserved hypothetical protein; Sugar octanoyltransferase likely involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP). Catalyzes the transfer of an octanoyl group from octanoyl-CoA to the C6 OH of the second glucose in diglucosylglycerate (DGG). DGG is the preferred acceptor, but to a lesser extent, GG (glucosylglycerate) can also be used as substrate. DGG and GG are the two earliest intermediates in MGLP biosynthesis; Belongs to the OctT acyltransferase family. (252 aa) |
| | rsfS | Conserved domain protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (133 aa) |
| | ABK70383.1 | IgiC, putative; Identified by match to protein family HMM PF01177. (261 aa) |
| | obg | GTP-binding protein Obg/CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (485 aa) |
| | rne | Ribonuclease, Rne/Rng family protein; Endoribonuclease that plays a central role in RNA processing and decay. Plays a major role in pre-16S rRNA maturation, probably generating the mature 5'-end, and a minor role in pre-5S and pre-23S rRNA maturation. (1037 aa) |
| | ABK74750.1 | Conserved hypothetical protein; Identified by similarity to GB:BAC71887.1; match to protein family HMM PF05872. (523 aa) |
| | ABK72295.1 | Identified by match to protein family HMM PF03734. (400 aa) |
| | rph | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (259 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (277 aa) |
| | ABK72131.1 | Putative helicase. (683 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (418 aa) |
| | wecA | Glycosyl trasferase; Involved in the biosynthesis of the disaccharide D-N- acetylglucosamine-L-rhamnose which plays an important role in the mycobacterial cell wall as a linker connecting arabinogalactan and peptidoglycan via a phosphodiester linkage. Catalyzes the transfer of the N-acetylglucosamine-1-phosphate (GlcNAc-1P) moiety from UDP-GlcNAc onto the carrier lipid decaprenyl phosphate (C50-P), yielding GlcNAc- pyrophosphoryl-decaprenyl (GlcNAc-PP-C50). (406 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (359 aa) |
| | ABK70260.1 | acyl-CoA synthase; Identified by match to protein family HMM PF00501. (532 aa) |
| | deaD | ATP-dependent rna helicase, dead/deah box family protein; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (581 aa) |
| | ABK73328.1 | ATPase. (1149 aa) |
| | ABK73693.1 | Mrp protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (379 aa) |
| | typA | GTP-binding protein TypA/BipA; Identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394. (633 aa) |
| | narJ | Nitrate reductase molybdenum cofactor assembly chaperone; Identified by match to protein family HMM PF02613; match to protein family HMM TIGR00684. (212 aa) |
| | ABK73324.1 | Sensor histidine kinase; Identified by similarity to GB:AAB48182.1; match to protein family HMM PF02518; match to protein family HMM PF06580. (399 aa) |
| | ABK75100.1 | Integral membrane protein. (757 aa) |
| | mazG | Transcriptional regulator, MazG family protein; Required to maintain the full capacity of the mycobacteria to respond to oxidative stress via the degradation of the oxidation- induced damaged nucleotides. It hydrolyzes all canonical (d)NTPs, as well as the mutagenic dUTP and 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'- triphosphate (8-oxo-dGTP). Also involved in the transcriptional activation of RelA in response to oxidative stress. (324 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1215 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (482 aa) |
| | ksgA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (297 aa) |
| | rsmI | Conserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (278 aa) |
| | ABK74222.1 | MK35 lipoprotein. (238 aa) |
| | ABK75886.1 | acetyl-CoA carboxylase carboxyltransferase; Identified by match to protein family HMM PF01039. (531 aa) |
| | pcrA | ATP-dependent DNA helicase PcrA; Identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073. (783 aa) |
| | ABK69944.1 | Acetyl-coenzyme a carboxylase carboxyl transferase; Identified by match to protein family HMM PF01039. (489 aa) |
| | ABK70222.1 | DNA or RNA helicase of superfamily protein II; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04851. (585 aa) |
| | ABK71854.1 | Putative long-chain fatty-acid--CoA ligase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR01746. (1173 aa) |
| | ABK76189.1 | Conserved hypothetical protein; Identified by match to protein family HMM PF02698. (211 aa) |
| | gvpK | Gas vesicle protein K; Identified by match to protein family HMM PF05121. (96 aa) |
| | ABK74340.1 | Identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350. (722 aa) |
| | ABK75995.1 | Glycine cleavage T-protein (aminomethyl transferase); Identified by match to protein family HMM PF01571; Belongs to the GcvT family. (359 aa) |
| | ABK70519.1 | Conserved hypothetical protein; Identified by match to protein family HMM PF08044. (215 aa) |
| | ABK73946.1 | D-alanyl-D-alanine dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. (218 aa) |
| | ABK71313.1 | Conserved hypothetical protein; Identified by match to protein family HMM PF02698. (192 aa) |
| | dacB | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; Carboxypeptidase that cleaves terminal D-alanine from peptidoglycan in the mycobacterial cell wall. May cleave L-Lys-D-Ala and/or D-Ala-D-Ala peptide bonds. Exerts important effects on mycobacterial cell morphology and cell division. Belongs to the peptidase S13 family. (480 aa) |
| | ABK71819.1 | Non-ribosomal peptide synthetase; Identified by match to protein family HMM PF00132; match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM TIGR01733; match to protein family HMM TIGR02353. (1311 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA sup [...] (936 aa) |
| | ABK70646.1 | ATP-dependent rna helicase, dead/deah box family protein; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271. (776 aa) |
| | ABK72436.1 | Conserved hypothetical protein. (215 aa) |
| | ABK75989.1 | Mur ligase family protein. (407 aa) |
| | ABK71221.1 | Cobyric acid synthase; Identified by match to protein family HMM PF07685. (239 aa) |
| | glfT1 | Glycosyl transferase, group 2 family protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the transfer of the first two galactofuranosyl (Galf) units from UDP- galactofuranose (UDP-Galf) onto the rhamnosyl-GlcNAc-diphospho- decaprenol (Rha-GlcNAc-PP-C50) acceptor, yielding galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50). Thus, GlfT1 is the initiator of galactan synthesis, while GlfT2 cont [...] (302 aa) |
| | ABK74530.1 | Identified by match to protein family HMM PF04138. (135 aa) |
| | dprE1 | Oxidoreductase, FAD-binding; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'substrate chann [...] (468 aa) |
| | dprE2 | Putative oxidoreductase in MprA 5'region; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'su [...] (254 aa) |
| | ABK72375.1 | Probable arabinosyltransferase A; Identified by match to protein family HMM PF04602. (1074 aa) |
| | ABK71134.1 | Probable arabinosyltransferase B; Identified by match to protein family HMM PF04602. (1080 aa) |
| | ABK72840.1 | Probable arabinosyltransferase A; Identified by match to protein family HMM PF04602. (1082 aa) |
| | ABK69744.1 | Antigen 85-C; Identified by match to protein family HMM PF00756. (337 aa) |
| | ABK75671.1 | Probable conserved transmembrane protein. (645 aa) |
| | ABK74962.1 | Prenyltransferase, UbiA family protein; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Catalyzes the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate (pRpp) to decaprenyl phosphate (DP) to form decaprenylphosphoryl-5-phosphoribose (DPPR). (318 aa) |
| | ABK71187.1 | PAP2 superfamily protein; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Could be involved in the dephosphorylation of decaprenylphosphoryl-5-phosphoribose (DPPR) to decaprenyl-phospho- ribose (DPR); Belongs to the PA-phosphatase related phosphoesterase family. (180 aa) |
| | glfT2 | Bifunctional udp-galactofuranosyl transferase glft; Involved in the galactan polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacteria cell wall. Thus, successively transfers approximately 28 galactofuranosyl (Galf) residues from UDP-galactofuranose (UDP-Galf) onto the galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50) acceptor produced by GlfT1, with alternating 1->5 and 1->6 links, forming a galactan domain with approximately 30 galactofu [...] (646 aa) |
| | glf | UDP-galactopyranose mutase; Identified by match to protein family HMM PF03275; match to protein family HMM TIGR00031. (412 aa) |
| | ABK74597.1 | Transcriptional regulator; Identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350. (623 aa) |
| | ABK73573.1 | Translation elongation factor EF-G; Identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM PF03764; match to protein family HMM TIGR00231. (731 aa) |
| | ABK70060.1 | Conserved hypothetical protein. (229 aa) |
| | hrpA | ATP-dependent helicase HrpA; Identified by match to protein family HMM PF00271; match to protein family HMM PF04408; match to protein family HMM PF07717; match to protein family HMM TIGR01967. (1316 aa) |
| | ABK75351.1 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (1024 aa) |
| | ponA1 | Penicillin-binding protein 1; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits) (By similarity). (785 aa) |
| | ABK70175.1 | Integral membrane protein MviN, putative; Identified by match to protein family HMM PF03023; match to protein family HMM TIGR01695. (1216 aa) |
| | gidB | Methyltransferase GidB; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (235 aa) |
| | ABK73535.1 | R3H domain-containing protein; Identified by match to protein family HMM PF01424. (183 aa) |
| | aftA | Membrane protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases. It is not able to add an Araf residue to a terminal Galf. (624 aa) |
| | gyrB | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (675 aa) |
| | gyrA | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (842 aa) |
| | cwsA | Conserved hypothetical protein; Required for regulated cell division, cell wall synthesis and the maintenance of cell shape; Belongs to the CwsA family. (136 aa) |
| | pbpA | Penicillin binding protein transpeptidase domain protein; Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation. (491 aa) |
| | ABK71056.1 | Cell cycle protein, FtsW/RodA/SpoVE family protein; Identified by match to protein family HMM PF01098; Belongs to the SEDS family. (471 aa) |
| | ABK75496.1 | Cell envelope-related function transcriptional attenuator common domain; Identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350. (533 aa) |
| | ABK76034.1 | Lipoprotein Lpps; Identified by match to protein family HMM PF03734. (346 aa) |
| | mmpL11 | MmpL11 protein; Contributes to cell wall biosynthesis and biofilm formation. Transports the mycolic acid-containing lipids monomeromycolyl diacylglycerol (MMDAG) and mycolate ester wax (WE) to the bacterial surface. (954 aa) |
| | ABK74656.1 | Membrane protein, MmpL family protein. (1013 aa) |
| | ABK70870.1 | Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039. (532 aa) |
| | aftD | Conserved hypothetical protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG. (1414 aa) |
| | ABK74005.1 | Peptide synthetase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM TIGR01720; match to protein family HMM TIGR01733; Belongs to the ATP-dependent AMP-binding enzyme family. (2429 aa) |
| | mps2 | Linear gramicidin synthetase subunit D; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR01720; match to protein family HMM TIGR01733; match to protein family HMM TIGR01746. (2559 aa) |
| | ABK72257.1 | Conserved hypothetical protein. (225 aa) |
| | topoM | DNA gyrase subunit A; Catalyzes the relaxation of negatively supercoiled DNA in the presence of ATP or dATP but not other nucleotides. Individual subunits have no activity. Not able to negatively supercoil DNA, it can however introduce positive supercoils in DNA. Relaxes positive supercoils in an ATP-dependent manner. Catenates and decatenates DNA. Generates dsDNA breaks in the presence of the quinolone antibiotic ciprofloxacin, showing it is a topoisomerase. (713 aa) |
| | topoN | DNA topoisomerase IV subunit B; Catalyzes the relaxation of negatively supercoiled DNA in the presence of ATP or dATP but not other nucleotides. Individual subunits have no activity. Not able to negatively supercoil DNA, it can however introduce positive supercoils in DNA. Relaxes positive supercoils in an ATP-dependent manner. Catenates and decatenates DNA. Generates dsDNA breaks in the presence of the quinolone antibiotic ciprofloxacin, showing it is a topoisomerase. (677 aa) |
| | ABK75368.1 | Putative conserved exported protein. (208 aa) |
| | ABK76213.1 | Identified by match to protein family HMM PF03734. (336 aa) |
| | ABK70772.1 | Isoniazid inductible protein IniC. (497 aa) |
| | ABK70534.1 | Conserved hypothetical protein. (215 aa) |
| | ABK74282.1 | Conserved hypothetical protein. (187 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (363 aa) |
| | ABK70477.1 | Identified by match to protein family HMM PF03734. (452 aa) |
| | ABK73972.1 | Cytochrome C biogenesis protein transmembrane region; Identified by match to protein family HMM PF02683. (261 aa) |
| | ABK69958.1 | Conserved membrane protein; Identified by match to protein family HMM PF05140. (549 aa) |
| | ccsB | Cytochrome c-type biogenesis protein CcsB; Identified by match to protein family HMM PF01578; match to protein family HMM TIGR03144. (331 aa) |
| | ABK75153.1 | Conserved hypothetical protein. (427 aa) |
| | ABK74523.1 | Urease accessory protein UreE 1; Identified by match to protein family HMM PF02814. (152 aa) |
| | ABK70452.1 | SNF2 domain protein; Identified by match to protein family HMM PF00176. (663 aa) |
| | gyrB-2 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (639 aa) |
| | iscS | Cysteine desulfurase IscS; Identified by match to protein family HMM PF00266. (386 aa) |
| | ABK72011.1 | DEAD/DEAH box helicase; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271. (1667 aa) |
| | ABK72212.1 | UvrD/Rep helicase; Identified by match to protein family HMM PF00580. (737 aa) |
| | ABK74691.1 | Conserved hypothetical protein. (512 aa) |
| | prfC | Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (538 aa) |
| | ABK75093.1 | Asp/Glu racemase; Identified by match to protein family HMM PF01177. (384 aa) |
| | ABK73659.1 | Identified by match to protein family HMM PF03734. (420 aa) |
| | recD | Exodeoxyribonuclease V, alpha subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA- dependent ATPase and 5'-3' helicase activity. When added to pre- assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity (By similarity). Unlike the case in E.coli, suppresses RecA-dependent [...] (554 aa) |
| | recB | Exodeoxyribonuclease V, beta subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes DNA-dependent ATPase activity, exonuclease activity and 3'-5' helicase activity (By similarity). Unlike the case in E.coli, suppresses RecA- dependent homologous recombination, is instead required for single- strand annealin [...] (1083 aa) |
| | recC | Exodeoxyribonuclease V, gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity (By similarity). Unlike the case in E.coli, suppresses RecA-dependent homologous recombination, is instead require [...] (1087 aa) |
| | ABK72176.1 | ATP-dependent RNA helicase; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271. (460 aa) |
| | ABK74638.1 | Hypothetical protein; Identified by Glimmer2; putative. (589 aa) |
| | ABK73802.1 | Ribosomal RNA adenine dimethylase family protein; Identified by match to protein family HMM PF00398; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (386 aa) |
| | ABK73230.1 | D-alanyl-D-alanine carboxypeptidase; Identified by match to protein family HMM PF00768; Belongs to the peptidase S11 family. (397 aa) |
| | ABK71317.1 | Type I topoisomerase. (338 aa) |
| | ABK75572.1 | Fe-S metabolism associated SufE; Identified by match to protein family HMM PF02657. (136 aa) |
| | ABK72280.1 | Transcriptional regulator, LytR family protein; Identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350. (493 aa) |
| | ABK71190.1 | Putative ribosome small subunit-dependent GTPase RsgA; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (335 aa) |
| | ABK74693.1 | Conserved hypothetical protein. (405 aa) |
| | ABK71608.1 | DEAD/DEAH box helicase; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; Belongs to the DEAD box helicase family. (502 aa) |
| | ABK73029.1 | Identified by match to protein family HMM PF00580; Belongs to the helicase family. UvrD subfamily. (1045 aa) |
| | ABK74484.1 | ATP-dependent DNA helicase; Identified by match to protein family HMM PF00580; Belongs to the helicase family. UvrD subfamily. (1087 aa) |
| | ABK71856.1 | ATP-dependent DNA helicase; Identified by match to protein family HMM PF00570; match to protein family HMM PF00580. (716 aa) |
| | ABK70753.1 | Conserved hypothetical protein; Identified by match to protein family HMM PF01883. (247 aa) |
| | fbpB | Antigen 85-C; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein. They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM (By similarity). (325 aa) |
| | prfB | Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (368 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Identified by match to protein family HMM PF01039. (502 aa) |
| | ABK69666.1 | Superfamily protein I DNA or RNA helicase. (736 aa) |
| | ABK70936.1 | Conserved hypothetical protein. (427 aa) |
| | ABK74642.1 | Cysteine desulfurase; Identified by match to protein family HMM PF00266; match to protein family HMM PF01212. (402 aa) |
| | hup | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. (208 aa) |
| | ddl | D-alanine--D-alanine ligase; Cell wall formation. (373 aa) |
| | recG | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (753 aa) |
| | ABK74399.1 | Conserved integral membrane protein; Identified by match to protein family HMM PF07884. (210 aa) |
| | ABK76183.1 | Putative methyltransferase; Identified by match to protein family HMM PF03602; match to protein family HMM TIGR00095. (169 aa) |
| | ABK70573.1 | Conserved hypothetical protein; Identified by match to protein family HMM PF02620. (203 aa) |
| | rnc | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the all rRNAs (23S, 16S and 5S) (Probable). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism (By similarity). (230 aa) |
| | smc | Chromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1195 aa) |
| | ABK73743.1 | D-alanyl-D-alanine carboxypeptidase; Identified by match to protein family HMM PF00768; Belongs to the peptidase S11 family. (275 aa) |
| | ABK71878.1 | D-alanyl-D-alanine carboxypeptidase; Identified by match to protein family HMM PF00768; Belongs to the peptidase S11 family. (296 aa) |
| | ABK70570.1 | Conserved hypothetical protein; Belongs to the UPF0109 family. (76 aa) |
| | rimM | 16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (173 aa) |
| | ABK73953.1 | LppW protein. (314 aa) |
| | ABK73694.1 | Decarboxylase; Identified by match to protein family HMM PF01177. (209 aa) |
| | ABK74467.1 | Decarboxylase; Identified by match to protein family HMM PF01177. (234 aa) |
| | ABK71115.1 | Mg-chelatase subunits D/I family protein, ComM subfamily protein; Identified by match to protein family HMM PF01078; match to protein family HMM PF07728; match to protein family HMM TIGR00368. (484 aa) |
| | frr | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | rlmN | Radical SAM enzyme, Cfr family protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (372 aa) |
| | ABK73973.1 | Gnat-family protein acetyltransferase; Identified by match to protein family HMM PF00583; match to protein family HMM TIGR03103. (609 aa) |
| | rimP | Conserved hypothetical protein; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. (181 aa) |
| | rbfA | Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (156 aa) |
| | rnj | Metallo-beta-lactamase superfamily protein; An RNase that has endonuclease and 5'-3' exonuclease activity. The 5'-exonuclease activity acts on 5'-monophosphate but not 5'-triphosphate ends. Endonuclease activity can cleave within 4 nucleotides of the 5'-end of a triphosphorylated RNA. Plays the major role in pre-23S rRNA maturation, and a minor role in processing of pre- 5S and pre-16S rRNA. (558 aa) |
| | ABK72081.1 | Identified by match to protein family HMM PF00583; Belongs to the acetyltransferase family. (160 aa) |
| | ABK70998.1 | Iron-sulfur cluster-binding protein, Rieske family protein, putative; Identified by match to protein family HMM PF01106. (307 aa) |
| | ABK72286.1 | ATPase involved in DNA repair; Identified by match to protein family HMM PF03993. (454 aa) |
| | ABK70716.1 | Identified by match to protein family HMM PF01476. (185 aa) |
| | ABK76195.1 | OB-fold nucleic acid binding domain protein; Identified by match to protein family HMM PF01336. (123 aa) |
| | ABK75612.1 | Putative RNA methyltransferase; Cg2084; identified by match to protein family HMM PF01938; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (397 aa) |
| | aftC | Putative conserved integral membrane protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG. (430 aa) |
| | ruvA | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (195 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (351 aa) |
| | ABK73002.1 | Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. (170 aa) |
| | mltG | Conserved hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (414 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (666 aa) |
| | ABK72425.1 | LemA protein; Identified by match to protein family HMM PF04011. (178 aa) |
| | sun | Ribosomal RNA small subunit methyltransferase B; Identified by match to protein family HMM PF01029; match to protein family HMM PF01189; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (464 aa) |
| | ABK73947.1 | Conserved hypothetical protein; Catalyzes the addition of alpha-(1->6)-mannose residue. (559 aa) |
| | sufB | FeS assembly protein SufB; Identified by match to protein family HMM PF01458; match to protein family HMM TIGR01980. (477 aa) |
| | sufD | FeS assembly protein SufD; Identified by match to protein family HMM PF01458; match to protein family HMM TIGR01981. (403 aa) |
| | ABK73018.1 | SUF system FeS assembly protein, NifU family protein; Identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994. (164 aa) |
| | ABK72929.1 | Conserved protein, DUF59; Identified by match to protein family HMM PF01883. (113 aa) |
| | ripA | Secreted cell wall-associated hydrolase; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan. Required for normal separation of daughter cells after cell division and for cell wall integrity (By similarity). (497 aa) |
