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| | gyrA | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (842 aa) |
| | dnaN | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (397 aa) |
| | gyrB | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (675 aa) |
| | ABK72876.1 | Formyl transferase; Identified by match to protein family HMM PF00551; match to protein family HMM PF02911. (322 aa) |
| | ABK74418.1 | IS1549, transposase; Identified by similarity to GP:2935133; match to protein family HMM PF01609. (488 aa) |
| | ABK71372.1 | Ribonuclease; Identified by match to protein family HMM PF00545. (125 aa) |
| | ABK74387.1 | ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (787 aa) |
| | ABK71706.1 | Conserved hypothetical protein; Identified by match to protein family HMM PF03706; match to protein family HMM TIGR00374. (363 aa) |
| | ABK71042.1 | Conserved hypothetical protein. (232 aa) |
| | trmB | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (240 aa) |
| | ABK75207.1 | Uracil DNA glycosylase superfamily protein; Identified by match to protein family HMM PF03167; match to protein family HMM TIGR00758. (209 aa) |
| | topoM | DNA gyrase subunit A; Catalyzes the relaxation of negatively supercoiled DNA in the presence of ATP or dATP but not other nucleotides. Individual subunits have no activity. Not able to negatively supercoil DNA, it can however introduce positive supercoils in DNA. Relaxes positive supercoils in an ATP-dependent manner. Catenates and decatenates DNA. Generates dsDNA breaks in the presence of the quinolone antibiotic ciprofloxacin, showing it is a topoisomerase. (713 aa) |
| | topoN | DNA topoisomerase IV subunit B; Catalyzes the relaxation of negatively supercoiled DNA in the presence of ATP or dATP but not other nucleotides. Individual subunits have no activity. Not able to negatively supercoil DNA, it can however introduce positive supercoils in DNA. Relaxes positive supercoils in an ATP-dependent manner. Catenates and decatenates DNA. Generates dsDNA breaks in the presence of the quinolone antibiotic ciprofloxacin, showing it is a topoisomerase. (677 aa) |
| | ABK72575.1 | Conserved hypothetical protein. (426 aa) |
| | ABK70202.1 | IS1137, transposase orfA; Similar at the nucleotide level to IS1137 in the IS Finder database; identified by match to protein family HMM PF01527. (108 aa) |
| | ABK70836.1 | Spou rRNA methylase family protein; Identified by match to protein family HMM PF00588. (214 aa) |
| | xth | Exodeoxyribonuclease III; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633. (260 aa) |
| | ABK70141.1 | HD domain protein; Identified by match to protein family HMM PF01966; match to protein family HMM TIGR00277. (199 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (451 aa) |
| | dinB | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (356 aa) |
| | ABK70452.1 | SNF2 domain protein; Identified by match to protein family HMM PF00176. (663 aa) |
| | ABK75340.1 | Conserved hypothetical protein; Identified by match to protein family HMM PF03706; match to protein family HMM TIGR00374. (791 aa) |
| | ABK72596.1 | Conserved hypothetical protein; Identified by match to protein family HMM PF01936. (289 aa) |
| | ABK74804.1 | ISMsm6, transposase; Identified by similarity to GP:2935133; match to protein family HMM PF01609. (545 aa) |
| | gyrB-2 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (639 aa) |
| | ABK75674.1 | Conserved hypothetical protein. (528 aa) |
| | ABK69628.1 | Conserved hypothetical protein. (274 aa) |
| | ABK75353.1 | ISMsm7, transposase orfA; Identified by similarity to GP:6572439; match to protein family HMM PF01527. (98 aa) |
| | ABK73558.1 | Conserved hypothetical protein. (2058 aa) |
| | ABK72011.1 | DEAD/DEAH box helicase; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271. (1667 aa) |
| | ABK72212.1 | UvrD/Rep helicase; Identified by match to protein family HMM PF00580. (737 aa) |
| | vapC | PIN domain protein; Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease, cleavage occurs after the first AU in the consensus sequence AUA(U/A); RNA secondary structure is probably important in substrate choice. Cuts in 5' and 3' UTRs. The TA system acts as a post-transcriptional regulator of carbon metabolism; in M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions. When overexpressed inhibits cell growth, [...] (129 aa) |
| | ABK72620.1 | Conserved hypothetical protein. (549 aa) |
| | recD | Exodeoxyribonuclease V, alpha subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA- dependent ATPase and 5'-3' helicase activity. When added to pre- assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity (By similarity). Unlike the case in E.coli, suppresses RecA-dependent [...] (554 aa) |
| | recB | Exodeoxyribonuclease V, beta subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes DNA-dependent ATPase activity, exonuclease activity and 3'-5' helicase activity (By similarity). Unlike the case in E.coli, suppresses RecA- dependent homologous recombination, is instead required for single- strand annealin [...] (1083 aa) |
| | recC | Exodeoxyribonuclease V, gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity (By similarity). Unlike the case in E.coli, suppresses RecA-dependent homologous recombination, is instead require [...] (1087 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit often mutates to generate rifampicin (Rif) resistance. Interaction with RbpA partially restores Rif-inhibited transcription; once the subunit is Rif-resistant however RbpA no longer stimulates transcription. (1169 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1317 aa) |
| | ABK70620.1 | Endonuclease IV; Identified by match to protein family HMM PF01261; match to protein family HMM TIGR00587. (250 aa) |
| | ABK71648.1 | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. (173 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (350 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (291 aa) |
| | ABK72176.1 | ATP-dependent RNA helicase; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271. (460 aa) |
| | ABK76097.1 | Putative DNA repair polymerase. (525 aa) |
| | dnaE2 | DNA polymerase III, alpha subunit, putative; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1095 aa) |
| | ABK71064.1 | RNA methyltransferase, TrmH family protein, group 2; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. (154 aa) |
| | ABK73802.1 | Ribosomal RNA adenine dimethylase family protein; Identified by match to protein family HMM PF00398; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (386 aa) |
| | xth-2 | Exodeoxyribonuclease III; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633. (273 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (338 aa) |
| | ABK72007.1 | IS3 family protein element, transposase orfA; Identified by similarity to GP:15619022; match to protein family HMM PF01527. (91 aa) |
| | ABK70034.1 | ISMsm8, transposase; Identified by similarity to SP:P37248; match to protein family HMM PF00665. (466 aa) |
| | ABK74886.1 | IS1137, transposase orfA; Similar at the nucleotide level to IS1137 in the IS Finder database; identified by match to protein family HMM PF01527. (91 aa) |
| | ABK74587.1 | ISMsm1, transposase orfA; Identified by similarity to GP:16551202; match to protein family HMM PF01527. (111 aa) |
| | ABK75694.1 | IS6120, transposase; Required for the transposition of the insertion element. (439 aa) |
| | ABK74960.1 | Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (383 aa) |
| | ABK75687.1 | RNA pseudouridine synthase family protein; Identified by match to protein family HMM PF00849. (291 aa) |
| | ABK74586.1 | Endonuclease VIII and dna n-glycosylase with an ap lyase activity; Identified by match to protein family HMM PF01149; match to protein family HMM PF06827; match to protein family HMM PF06831; Belongs to the FPG family. (252 aa) |
| | ABK70223.1 | DEAD/DEAH box helicase; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271. (1507 aa) |
| | rnz | Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (309 aa) |
| | ABK71317.1 | Type I topoisomerase. (338 aa) |
| | selA | L-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (426 aa) |
| | ABK74652.1 | IS1549, transposase; Identified by similarity to GP:2935133; match to protein family HMM PF01609. (488 aa) |
| | ybaK | Identified by match to protein family HMM PF04073; match to protein family HMM TIGR00011; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (163 aa) |
| | ABK71608.1 | DEAD/DEAH box helicase; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; Belongs to the DEAD box helicase family. (502 aa) |
| | ABK72629.1 | Conserved hypothetical protein. (232 aa) |
| | ABK73029.1 | Identified by match to protein family HMM PF00580; Belongs to the helicase family. UvrD subfamily. (1045 aa) |
| | ABK74484.1 | ATP-dependent DNA helicase; Identified by match to protein family HMM PF00580; Belongs to the helicase family. UvrD subfamily. (1087 aa) |
| | ABK72871.1 | NADH pyrophosphatase; Identified by match to protein family HMM PF00293. (311 aa) |
| | ABK71856.1 | ATP-dependent DNA helicase; Identified by match to protein family HMM PF00570; match to protein family HMM PF00580. (716 aa) |
| | ABK70121.1 | ATP dependent DNA ligase. (321 aa) |
| | ABK69666.1 | Superfamily protein I DNA or RNA helicase. (736 aa) |
| | ABK71560.1 | Conserved hypothetical protein. (108 aa) |
| | ABK71634.1 | Identified by match to protein family HMM PF00899. (723 aa) |
| | dnl1 | DNA ligase I, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. (509 aa) |
| | dinB-2 | DNA polymerase IV; Identified by match to protein family HMM PF00817. (356 aa) |
| | ligA | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (Probable). Probably the only ligase required for non-homologous end joining (NHEJ) repair of 3-overhangs; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (701 aa) |
| | gatC | glutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (99 aa) |
| | gatA-2 | glutamyl-tRNA(Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (494 aa) |
| | gatB | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (503 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (486 aa) |
| | ung | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (227 aa) |
| | recG | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (753 aa) |
| | rnc | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the all rRNAs (23S, 16S and 5S) (Probable). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism (By similarity). (230 aa) |
| | mutM | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Acts on oxidized purines, such as 7,8-dihydro-8- oxoguanine (8-oxoG) when paired with C, G or T. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates; Belongs to the FPG family. (285 aa) |
| | trmD | tRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (225 aa) |
| | rnhB | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (272 aa) |
| | xerC | Tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (300 aa) |
| | rlmN | Radical SAM enzyme, Cfr family protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (372 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (585 aa) |
| | ABK72496.1 | Mini-circle putative transposase for; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (403 aa) |
| | truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (303 aa) |
| | ABK72583.1 | ISMsm8, transposase; Identified by similarity to SP:P37248; match to protein family HMM PF00665. (466 aa) |
| | ABK73016.1 | IS1137, transposase orfA; Similar at the nucleotide level to IS1137 in the IS Finder database; identified by match to protein family HMM PF01527. (108 aa) |
| | ABK74746.1 | Conserved hypothetical protein; Identified by match to protein family HMM PF06224. (398 aa) |
| | rnj | Metallo-beta-lactamase superfamily protein; An RNase that has endonuclease and 5'-3' exonuclease activity. The 5'-exonuclease activity acts on 5'-monophosphate but not 5'-triphosphate ends. Endonuclease activity can cleave within 4 nucleotides of the 5'-end of a triphosphorylated RNA. Plays the major role in pre-23S rRNA maturation, and a minor role in processing of pre- 5S and pre-16S rRNA. (558 aa) |
| | recA | Protein RecA; Required for homologous recombination (HR) and the bypass of mutagenic DNA lesions (double strand breaks, DSB) by the SOS response. Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. Numerous X-ray crystals have been resolved under different conditions which indicate the flexibility of the protein, essential to its function. Gln-196 contributes to this plasticity by acting as a switch residue, which transmits the ef [...] (349 aa) |
| | miaA | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (302 aa) |
| | ABK76195.1 | OB-fold nucleic acid binding domain protein; Identified by match to protein family HMM PF01336. (123 aa) |
| | ABK75612.1 | Putative RNA methyltransferase; Cg2084; identified by match to protein family HMM PF01938; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (397 aa) |
| | ABK71031.1 | ISMsm1, transposase orfA; Similar at the protein level to ISRru1 in the IS Finder database; identified by similarity to GP:16551202; match to protein family HMM PF01527. (111 aa) |
| | ABK74786.1 | IS1549, transposase; Identified by similarity to GP:2935133; match to protein family HMM PF01609. (488 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (684 aa) |
| | ruvC | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (185 aa) |
| | ruvA | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (195 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (351 aa) |
| | hisS | histidyl-tRNA synthetase; Identified by match to protein family HMM PF00587; match to protein family HMM PF03129; match to protein family HMM TIGR00442. (426 aa) |
| | ABK72638.1 | Identified by match to protein family HMM PF01425; Belongs to the amidase family. (447 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (598 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (896 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (107 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (666 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (312 aa) |
| | sun | Ribosomal RNA small subunit methyltransferase B; Identified by match to protein family HMM PF01029; match to protein family HMM PF01189; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (464 aa) |
| | uvrC | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (706 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1040 aa) |
| | dinB-3 | DNA polymerase IV 1; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (463 aa) |
| | ABK73618.1 | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (309 aa) |
| | ABK72022.1 | DNA polymerase III alpha subunit; Identified by match to protein family HMM PF01336; match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. (1184 aa) |
| | ABK71058.1 | Conserved hypothetical protein. (560 aa) |
| | ABK73140.1 | Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (403 aa) |
| | ABK71766.1 | IS1549, transposase; Identified by similarity to GP:2935133; match to protein family HMM PF01609. (488 aa) |
| | ABK69865.1 | Metal-dependent phosphohydrolase; Identified by match to protein family HMM PF01966; match to protein family HMM TIGR00277. (218 aa) |
| | rluB | Ribosomal large subunit pseudouridine synthase B; Identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; Belongs to the pseudouridine synthase RsuA family. (247 aa) |
| | xerD | Tyrosine recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (318 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (440 aa) |
| | ABK75473.1 | 3-methyladenine DNA glycosylase; Identified by match to protein family HMM PF02245; match to protein family HMM TIGR00567; Belongs to the DNA glycosylase MPG family. (207 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit; Identified by match to protein family HMM PF01588; match to protein family HMM PF03147; match to protein family HMM PF03483; match to protein family HMM PF03484; match to protein family HMM TIGR00472; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (832 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit; Identified by match to protein family HMM PF01409; match to protein family HMM PF02912; match to protein family HMM TIGR00468; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (356 aa) |
| | ABK71160.1 | RNA methyltransferase, TrmH family protein; Identified by match to protein family HMM PF00588; match to protein family HMM PF08032; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (252 aa) |
| | lysX | lysyl-tRNA synthetase; Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine res [...] (1089 aa) |
| | ABK69531.1 | Conserved hypothetical protein. (394 aa) |
| | uvrA | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (964 aa) |
| | uvrB | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (736 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (908 aa) |
| | ABK72031.1 | 5'-3' exonuclease; Identified by match to protein family HMM PF01367; match to protein family HMM PF02739. (338 aa) |
| | ABK73134.1 | DEAD/DEAH box helicase; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04851; match to protein family HMM PF08148. (912 aa) |
| | ABK76023.1 | tRNA (adenine-N(1)-)-methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. (282 aa) |
| | ABK73116.1 | Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (403 aa) |
| | ABK73104.1 | Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (403 aa) |
| | ABK72352.1 | Transposase; Identified by match to protein family HMM PF01527. (102 aa) |
| | ABK73094.1 | Transposase; Identified by match to protein family HMM PF01527. (102 aa) |
| | ABK70392.1 | Transposase, Mutator family protein; Required for the transposition of the insertion element. (391 aa) |
| | ABK73066.1 | Identified by match to protein family HMM PF00589; match to protein family HMM PF02899; Belongs to the 'phage' integrase family. (346 aa) |
| | ABK75647.1 | Putative transposase; Identified by match to protein family HMM PF00589. (741 aa) |
| | ABK71388.1 | Putative transposase. (49 aa) |
| | ABK72574.1 | IS6120, transposase; Identified by similarity to SP:P35883; match to protein family HMM PF00872. (439 aa) |
| | mraW | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (326 aa) |
| | ABK74248.1 | Conserved hypothetical protein; Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA. (169 aa) |
| | ABK74084.1 | DNA polymerase III, epsilon subunit; Identified by match to protein family HMM PF00929; match to protein family HMM PF01541; match to protein family HMM TIGR00573. (672 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (143 aa) |
| | ABK69912.1 | Phosphoglycerate mutase; Identified by match to protein family HMM PF00300. (365 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (636 aa) |
| | glyS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (461 aa) |
| | ybeY | Conserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (178 aa) |
| | ABK71219.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (401 aa) |
| | rnz-2 | Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. (286 aa) |
| | ABK72472.1 | DNA polymerase III, delta subunit; Identified by match to protein family HMM PF06144. (319 aa) |
| | rne | Ribonuclease, Rne/Rng family protein; Endoribonuclease that plays a central role in RNA processing and decay. Plays a major role in pre-16S rRNA maturation, probably generating the mature 5'-end, and a minor role in pre-5S and pre-23S rRNA maturation. (1037 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (872 aa) |
| | ABK75773.1 | Putative formamidopyrimidine-DNA glycosylase; Identified by match to protein family HMM PF01149; match to protein family HMM PF06831; Belongs to the FPG family. (268 aa) |
| | orn | Oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family. (216 aa) |
| | rph | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (259 aa) |
| | ABK72005.1 | Metal-dependent hydrolase of the beta-lactamase superfamily protein III. (252 aa) |
| | ABK72131.1 | Putative helicase. (683 aa) |
| | nucS | Conserved hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (224 aa) |
| | ABK70918.1 | Transcriptional regulator, Ada family protein/DNA-3-methyladenine glycosylase II; Identified by match to protein family HMM PF00165; match to protein family HMM PF00730; match to protein family HMM PF02805; match to protein family HMM PF06029. (512 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (664 aa) |
| | argS | arginyl-tRNA synthetase; Identified by match to protein family HMM PF00750; match to protein family HMM PF03485; match to protein family HMM PF05746; match to protein family HMM TIGR00456. (550 aa) |
| | ABK76105.1 | T/U mismatch-specific DNA glycosylase. (162 aa) |
| | ABK75253.1 | uracil-DNA glycosylase superfamily protein; Identified by match to protein family HMM PF03167. (290 aa) |
| | deaD | ATP-dependent rna helicase, dead/deah box family protein; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (581 aa) |
| | ABK73328.1 | ATPase. (1149 aa) |
| | tag | DNA-3-methyladenine glycosylase I; Identified by match to protein family HMM PF03352; match to protein family HMM TIGR00624. (209 aa) |
| | ABK73160.1 | ISMsm1, transposase orfA; Identified by similarity to GP:16551202; match to protein family HMM PF01527. (111 aa) |
| | ABK75772.1 | Conserved hypothetical protein. (202 aa) |
| | ABK74045.1 | Methyltransferase type 11. (216 aa) |
| | ABK75521.1 | IS1549, transposase; Identified by similarity to GP:2935133; match to protein family HMM PF01609. (488 aa) |
| | xseA | Exodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (404 aa) |
| | xseB | Exodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (70 aa) |
| | recQ | ATP-dependent DNA helicase RecQ; Identified by match to protein family HMM PF00271. (381 aa) |
| | ABK70942.1 | ATP-dependent DNA helicase RecQ; Identified by match to protein family HMM PF00270. (174 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1215 aa) |
| | pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (191 aa) |
| | ksgA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (297 aa) |
| | ABK72961.1 | Deoxyribonuclease; Identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010. (284 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (515 aa) |
| | rsmI | Conserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (278 aa) |
| | pcrA | ATP-dependent DNA helicase PcrA; Identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073. (783 aa) |
| | ABK70606.1 | formamidopyrimidine-DNA glycosylase; Identified by match to protein family HMM PF01149; match to protein family HMM PF06831; Belongs to the FPG family. (288 aa) |
| | rnhA | RNase H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (159 aa) |
| | ligD-2 | DNA ligase; With Ku forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang DNA double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ during 3'-overhang repair. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. Acts as a DNA ligase on singly nicked dsDNA, as a DNA-directed DNA polymerase on 5' overhangs, and adds non-templated nucleotides to 3' overhangs (terminal transferase). Fills in gaps in d [...] (755 aa) |
| | ABK76010.1 | YbaK/prolyl-tRNA synthetase associated region; Identified by match to protein family HMM PF04073. (159 aa) |
| | ABK71293.1 | 23s ribosomal RNA methyltransferase; Identified by match to protein family HMM PF00588. (277 aa) |
| | ABK70438.1 | Conserved hypothetical protein. (751 aa) |
| | ABK70222.1 | DNA or RNA helicase of superfamily protein II; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04851. (585 aa) |
| | ABK69711.1 | Putative cyanamide hydratase; Identified by match to protein family HMM PF01966. (199 aa) |
| | ABK76164.1 | tRNA-dihydrouridine synthase, putative; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (389 aa) |
| | ABK73907.1 | ATP-dependent DNA helicase; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM TIGR00614. (691 aa) |
| | ABK70144.1 | Transposase; Identified by match to protein family HMM PF01548; match to protein family HMM PF02371. (399 aa) |
| | ABK75506.1 | RNA methyltransferase, TrmH family protein, group 3; Identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (314 aa) |
| | cysS-2 | cysteinyl-tRNA synthetase; Identified by match to protein family HMM PF01406; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. (477 aa) |
| | radA | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function (By similarity). Also inhibits the diadenylate cyclase activity of DisA ; Belongs to the Rec [...] (466 aa) |
| | mutY | Base excision DNA repair protein, HhH-GPD family protein; Adenine glycosylase active on G:A and C:A mispairs, as well as processing 7,8-dihydro-8-oxoguanine:A (8-oxoG) mismatches. Belongs to the Nth/MutY family. (293 aa) |
| | lysS | lysyl-tRNA synthetase; Identified by match to protein family HMM PF00152; match to protein family HMM PF01336; match to protein family HMM TIGR00499; Belongs to the class-II aminoacyl-tRNA synthetase family. (507 aa) |
| | ABK72015.1 | DNA polymerase III subunit delta; Identified by match to protein family HMM TIGR00678. (402 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA sup [...] (936 aa) |
| | ABK70646.1 | ATP-dependent rna helicase, dead/deah box family protein; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271. (776 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (259 aa) |
| | recR | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (203 aa) |
| | dnaX | DNA polymerase III gamma/tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (665 aa) |
| | ligD | DNA polymerase LigD, polymerase domain; Identified by match to protein family HMM TIGR02778. (350 aa) |
| | ligC | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. Belongs to the ATP-dependent DNA ligase family. (348 aa) |
| | ligC2 | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. (354 aa) |
| | gltX-2 | glutamyl-tRNA synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (292 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (414 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (417 aa) |
| | dinP | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (403 aa) |
| | ABK73914.1 | Conserved hypothetical protein. (294 aa) |
| | ABK70060.1 | Conserved hypothetical protein. (229 aa) |
| | hrpA | ATP-dependent helicase HrpA; Identified by match to protein family HMM PF00271; match to protein family HMM PF04408; match to protein family HMM PF07717; match to protein family HMM TIGR01967. (1316 aa) |
| | ABK75216.1 | Integral membrane protein. (91 aa) |
| | uvrA-2 | Excinuclease ABC, A subunit; Identified by match to protein family HMM PF00005; match to protein family HMM TIGR00630. (840 aa) |
| | ABK70059.1 | Transposase; Identified by match to protein family HMM PF01527. (102 aa) |
| | ABK75351.1 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (1024 aa) |
| | leuS | leucyl-tRNA synthetase; Identified by match to protein family HMM TIGR00396; Belongs to the class-I aminoacyl-tRNA synthetase family. (953 aa) |
| | gidB | Methyltransferase GidB; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (235 aa) |
| | rnpA | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (123 aa) |
