(43 nodes) RmlC-like jelly roll fold network (Mycolicibacterium smegmatis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ectC	Ectoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (130 aa)
	ABK75123.1	Identified by match to protein family HMM PF01381; match to protein family HMM PF07883. (192 aa)
	ABK74796.1	Cupin 2, conserved barrel; Identified by match to protein family HMM PF07883. (144 aa)
	ABK71756.1	Cupin domain protein; Identified by match to protein family HMM PF07883. (302 aa)
	ABK74092.1	Transcriptional regulator, AraC family protein; Identified by match to protein family HMM PF00165. (257 aa)
	ABK73092.1	Protein IolB; Identified by match to protein family HMM PF06845. (291 aa)
	ABK71135.1	Cysteine dioxygenase type I superfamily protein; Identified by match to protein family HMM PF05995. (182 aa)
	ABK70370.1	Cyclic nucleotide-binding protein; Catalyzes specifically the acetylation of the epsilon-amino group of a highly conserved lysine residue in acetyl-CoA synthetase (ACS) and of the universal stress protein (USP) MSMEG_4207. Acetylation results in the inactivation of ACS activity and could be important for mycobacteria to adjust to environmental changes. (333 aa)
	ABK74438.1	Conserved hypothetical protein; Identified by match to protein family HMM PF06172. (148 aa)
	ABK75103.1	Cupin domain protein; Identified by match to protein family HMM PF07883. (117 aa)
	ABK75281.1	Cupin domain protein; Identified by match to protein family HMM PF07883. (135 aa)
	rfbC	dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (184 aa)
	ABK71206.1	Transcriptional regulator, Crp/Fnr family protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00325. (224 aa)
	ABK74998.1	Transcriptional regulator; Identified by match to protein family HMM PF01381; match to protein family HMM PF07883. (216 aa)
	ABK71876.1	Conserved hypothetical protein. (145 aa)
	ABK71788.1	Transcriptional regulatory protein; Identified by match to protein family HMM PF00165. (267 aa)
	ABK76090.1	Cupin domain protein; Identified by match to protein family HMM PF07883. (184 aa)
	ABK71091.1	Pirin domain protein; Identified by match to protein family HMM PF02678; match to protein family HMM PF05726; Belongs to the pirin family. (321 aa)
	ABK74968.1	Chromosome condensation protein; Identified by match to protein family HMM PF02678; match to protein family HMM PF05726; Belongs to the pirin family. (324 aa)
	ABK70417.1	Identified by match to protein family HMM PF02678; Belongs to the pirin family. (238 aa)
	ABK73796.1	Transcriptional regulator, Crp/Fnr family protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00325. (224 aa)
	ABK70249.1	Cupin domain protein; Identified by match to protein family HMM PF07883. (190 aa)
	ABK73419.1	Transcription regulator; Identified by match to protein family HMM PF01381; match to protein family HMM PF07883. (189 aa)
	ABK74601.1	Identified by match to protein family HMM PF01381; match to protein family HMM PF07883. (201 aa)
	ABK70070.1	Conserved hypothetical protein. (333 aa)
	ABK69592.1	Conserved hypothetical protein; Identified by match to protein family HMM PF05899. (133 aa)
	rmlC	dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (201 aa)
	ABK72199.1	Two-component sensor histidine kinase; Identified by match to protein family HMM PF00027; match to protein family HMM PF02518. (490 aa)
	ABK73012.1	Cupin domain protein; Identified by match to protein family HMM PF07883. (187 aa)
	ABK70259.1	Cupin domain protein; Identified by match to protein family HMM PF07883. (136 aa)
	ABK73312.1	Conserved hypothetical protein; Identified by match to protein family HMM PF06172. (145 aa)
	ABK75767.1	Conserved hypothetical protein. (126 aa)
	ABK74737.1	Anti-sigm factor, ChrR. (122 aa)
	manA	Mannose-6-phosphate isomerase, class I; Identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218. (379 aa)
	ABK73131.1	Conserved hypothetical protein. (126 aa)
	hmgA	Homogentisate 1,2-dioxygenase; Identified by match to protein family HMM PF04209. (367 aa)
	ABK75642.1	Glucose-6-phosphate isomerase, putative. (54 aa)
	ABK73791.1	Oxalate decarboxylase OxdC, putative; Identified by match to protein family HMM PF00190; match to protein family HMM PF07883. (348 aa)
	ABK70635.1	Cupin 2, conserved barrel. (98 aa)
	ABK73193.1	Cupin domain protein; Identified by match to protein family HMM PF07883. (139 aa)
	ABK72108.1	Cupin domain protein; Identified by match to protein family HMM PF07883. (175 aa)
	ABK76106.1	Probable conserved transmembrane protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00924. (464 aa)
	ABK76238.1	Cupin 2 protein; Identified by match to protein family HMM PF07883. (187 aa)

Your Current Organism:

Mycolicibacterium smegmatis

NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABK70070.1	ABK75642.1	MSMEG_1371	MSMEG_2114	Conserved hypothetical protein.	Glucose-6-phosphate isomerase, putative.	0.499
ABK70070.1	manA	MSMEG_1371	MSMEG_1836	Conserved hypothetical protein.	Mannose-6-phosphate isomerase, class I; Identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218.	0.901
ABK70249.1	ABK71876.1	MSMEG_0644	MSMEG_6488	Cupin domain protein; Identified by match to protein family HMM PF07883.	Conserved hypothetical protein.	0.637
ABK70259.1	ABK75767.1	MSMEG_1688	MSMEG_1754	Cupin domain protein; Identified by match to protein family HMM PF07883.	Conserved hypothetical protein.	0.498
ABK70417.1	ABK74968.1	MSMEG_0215	MSMEG_0089	Identified by match to protein family HMM PF02678; Belongs to the pirin family.	Chromosome condensation protein; Identified by match to protein family HMM PF02678; match to protein family HMM PF05726; Belongs to the pirin family.	0.450
ABK71091.1	hmgA	MSMEG_0049	MSMEG_2075	Pirin domain protein; Identified by match to protein family HMM PF02678; match to protein family HMM PF05726; Belongs to the pirin family.	Homogentisate 1,2-dioxygenase; Identified by match to protein family HMM PF04209.	0.404
ABK71206.1	ABK73796.1	MSMEG_6189	MSMEG_0539	Transcriptional regulator, Crp/Fnr family protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00325.	Transcriptional regulator, Crp/Fnr family protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00325.	0.904
ABK71756.1	ABK73791.1	MSMEG_4441	MSMEG_2254	Cupin domain protein; Identified by match to protein family HMM PF07883.	Oxalate decarboxylase OxdC, putative; Identified by match to protein family HMM PF00190; match to protein family HMM PF07883.	0.422
ABK71756.1	ABK75767.1	MSMEG_4441	MSMEG_1754	Cupin domain protein; Identified by match to protein family HMM PF07883.	Conserved hypothetical protein.	0.606
ABK71788.1	ABK74092.1	MSMEG_6546	MSMEG_4601	Transcriptional regulatory protein; Identified by match to protein family HMM PF00165.	Transcriptional regulator, AraC family protein; Identified by match to protein family HMM PF00165.	0.414
ABK71876.1	ABK70249.1	MSMEG_6488	MSMEG_0644	Conserved hypothetical protein.	Cupin domain protein; Identified by match to protein family HMM PF07883.	0.637
ABK72108.1	ABK76090.1	MSMEG_3484	MSMEG_6861	Cupin domain protein; Identified by match to protein family HMM PF07883.	Cupin domain protein; Identified by match to protein family HMM PF07883.	0.429
ABK72199.1	ABK76106.1	MSMEG_1515	MSMEG_3579	Two-component sensor histidine kinase; Identified by match to protein family HMM PF00027; match to protein family HMM PF02518.	Probable conserved transmembrane protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00924.	0.422
ABK72199.1	rmlC	MSMEG_1515	MSMEG_1510	Two-component sensor histidine kinase; Identified by match to protein family HMM PF00027; match to protein family HMM PF02518.	dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.	0.457
ABK73012.1	ABK76090.1	MSMEG_1585	MSMEG_6861	Cupin domain protein; Identified by match to protein family HMM PF07883.	Cupin domain protein; Identified by match to protein family HMM PF07883.	0.500
ABK73419.1	ABK74601.1	MSMEG_1139	MSMEG_1151	Transcription regulator; Identified by match to protein family HMM PF01381; match to protein family HMM PF07883.	Identified by match to protein family HMM PF01381; match to protein family HMM PF07883.	0.412
ABK73419.1	ABK74998.1	MSMEG_1139	MSMEG_6265	Transcription regulator; Identified by match to protein family HMM PF01381; match to protein family HMM PF07883.	Transcriptional regulator; Identified by match to protein family HMM PF01381; match to protein family HMM PF07883.	0.437
ABK73791.1	ABK71756.1	MSMEG_2254	MSMEG_4441	Oxalate decarboxylase OxdC, putative; Identified by match to protein family HMM PF00190; match to protein family HMM PF07883.	Cupin domain protein; Identified by match to protein family HMM PF07883.	0.422
ABK73796.1	ABK71206.1	MSMEG_0539	MSMEG_6189	Transcriptional regulator, Crp/Fnr family protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00325.	Transcriptional regulator, Crp/Fnr family protein; Identified by match to protein family HMM PF00027; match to protein family HMM PF00325.	0.904
ABK74092.1	ABK71788.1	MSMEG_4601	MSMEG_6546	Transcriptional regulator, AraC family protein; Identified by match to protein family HMM PF00165.	Transcriptional regulatory protein; Identified by match to protein family HMM PF00165.	0.414