(44 nodes) Rossmann-like alpha/beta/alpha sandwich fold network (Mycolicibacterium smegmatis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	nadD	Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (222 aa)
	nadE	Glutamine-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (680 aa)
	trmU	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (356 aa)
	coaD	Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (158 aa)
	ABK74757.1	Deoxyribodipyrimidine photo-lyase; Identified by match to protein family HMM PF00875; match to protein family HMM PF03441; Belongs to the DNA photolyase family. (452 aa)
	asnB	Asparagine synthase (glutamine-hydrolyzing); Identified by match to protein family HMM PF00310; match to protein family HMM PF00733; match to protein family HMM TIGR01536; match to protein family HMM TIGR03104. (601 aa)
	ribF	Riboflavin biosynthesis protein RibF; Identified by match to protein family HMM PF01687; match to protein family HMM PF06574; match to protein family HMM TIGR00083; match to protein family HMM TIGR00125; Belongs to the ribF family. (325 aa)
	ileS	isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1040 aa)
	ABK70785.1	Universal stress protein family protein, putative; Identified by match to protein family HMM PF00582. (162 aa)
	tyrS	tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (440 aa)
	argG	Argininosuccinate synthase; Identified by match to protein family HMM PF00764; match to protein family HMM TIGR00032; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (399 aa)
	ABK75086.1	Universal stress protein family protein, putative; Identified by match to protein family HMM PF00582. (147 aa)
	ABK73278.1	Identified by match to protein family HMM PF00582. (299 aa)
	ABK72096.1	Identified by match to protein family HMM PF00582. (263 aa)
	ABK71390.1	Identified by match to protein family HMM PF00582. (293 aa)
	ABK69884.1	Identified by match to protein family HMM PF00582. (273 aa)
	ABK73928.1	Identified by match to protein family HMM PF00582; Belongs to the universal stress protein A family. (294 aa)
	cysS	cysteinyl-tRNA synthetase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins. (412 aa)
	ABK72172.1	Identified by match to protein family HMM PF00582. (130 aa)
	asnB-2	Asparagine synthase (glutamine-hydrolyzing); Identified by match to protein family HMM PF00310; match to protein family HMM PF00733; match to protein family HMM TIGR01536. (658 aa)
	ABK73898.1	Identified by match to protein family HMM PF00582. (272 aa)
	cysH	Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (236 aa)
	ABK73630.1	Transporter, major facilitator family protein, putative; Identified by match to protein family HMM PF00582; match to protein family HMM PF07690. (666 aa)
	ABK71955.1	Phosphoadenosine phosphosulfate reductase; Identified by match to protein family HMM PF01507. (282 aa)
	guaA	Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. (520 aa)
	trpS	tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (338 aa)
	etfB	Electron transfer flavoprotein, beta subunit; Identified by similarity to SP:O85691; match to protein family HMM PF01012. (263 aa)
	valS	valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (872 aa)
	argS	arginyl-tRNA synthetase; Identified by match to protein family HMM PF00750; match to protein family HMM PF03485; match to protein family HMM PF05746; match to protein family HMM TIGR00456. (550 aa)
	cysD	Sulfate adenylyltransferase, small subunit; Identified by similarity to SP:P21156; match to protein family HMM PF01507; match to protein family HMM TIGR02039. (311 aa)
	ABK71731.1	Identified by match to protein family HMM PF00582. (280 aa)
	ABK75585.1	Sensor protein KdpD; Identified by match to protein family HMM PF00512; match to protein family HMM PF00582; match to protein family HMM PF02518; match to protein family HMM PF02702. (839 aa)
	metG	methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (515 aa)
	ABK69770.1	Transporter; Identified by match to protein family HMM PF00324. (608 aa)
	ABK70087.1	Identified by match to protein family HMM PF00582. (298 aa)
	ABK75323.1	Identified by match to protein family HMM PF00582. (292 aa)
	ABK76189.1	Conserved hypothetical protein; Identified by match to protein family HMM PF02698. (211 aa)
	cysS-2	cysteinyl-tRNA synthetase; Identified by match to protein family HMM PF01406; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family. (477 aa)
	panC	Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (314 aa)
	tilS	tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (322 aa)
	gltX-2	glutamyl-tRNA synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (292 aa)
	leuS	leucyl-tRNA synthetase; Identified by match to protein family HMM TIGR00396; Belongs to the class-I aminoacyl-tRNA synthetase family. (953 aa)
	etfA	Electron transfer flavoprotein, alpha subunit; Identified by similarity to SP:P38974; match to protein family HMM PF00766; match to protein family HMM PF01012. (313 aa)
	gltX	glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (486 aa)

Your Current Organism:

Mycolicibacterium smegmatis

NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABK69770.1	ABK70087.1	MSMEG_5473	MSMEG_5474	Transporter; Identified by match to protein family HMM PF00324.	Identified by match to protein family HMM PF00582.	0.864
ABK69884.1	ABK72096.1	MSMEG_3945	MSMEG_3939	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.476
ABK69884.1	ABK72172.1	MSMEG_3945	MSMEG_4207	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.760
ABK70087.1	ABK69770.1	MSMEG_5474	MSMEG_5473	Identified by match to protein family HMM PF00582.	Transporter; Identified by match to protein family HMM PF00324.	0.864
ABK70087.1	ABK72172.1	MSMEG_5474	MSMEG_4207	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.777
ABK70785.1	ABK72172.1	MSMEG_3308	MSMEG_4207	Universal stress protein family protein, putative; Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.777
ABK71390.1	ABK72096.1	MSMEG_3940	MSMEG_3939	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.707
ABK71390.1	ABK72172.1	MSMEG_3940	MSMEG_4207	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.816
ABK71731.1	ABK72096.1	MSMEG_5245	MSMEG_3939	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.426
ABK71731.1	ABK72172.1	MSMEG_5245	MSMEG_4207	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.775
ABK72096.1	ABK69884.1	MSMEG_3939	MSMEG_3945	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.476
ABK72096.1	ABK71390.1	MSMEG_3939	MSMEG_3940	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.707
ABK72096.1	ABK71731.1	MSMEG_3939	MSMEG_5245	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.426
ABK72096.1	ABK72172.1	MSMEG_3939	MSMEG_4207	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.778
ABK72096.1	ABK73278.1	MSMEG_3939	MSMEG_3936	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.653
ABK72096.1	ABK73928.1	MSMEG_3939	MSMEG_3950	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582; Belongs to the universal stress protein A family.	0.476
ABK72096.1	ABK75323.1	MSMEG_3939	MSMEG_5733	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.467
ABK72172.1	ABK69884.1	MSMEG_4207	MSMEG_3945	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.760
ABK72172.1	ABK70087.1	MSMEG_4207	MSMEG_5474	Identified by match to protein family HMM PF00582.	Identified by match to protein family HMM PF00582.	0.777
ABK72172.1	ABK70785.1	MSMEG_4207	MSMEG_3308	Identified by match to protein family HMM PF00582.	Universal stress protein family protein, putative; Identified by match to protein family HMM PF00582.	0.777