6 items (Mycolicibacterium smegmatis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pks5	Mycocerosic acid synthase; Polyketide synthase involved in the biosynthesis of 2,4- dimethyl-2-eicosenoic acid, a lipid component of the lipooligosaccharides (LOS) which are not located at the bacterial surface but rather in deeper compartments of the cell envelope of M.smegmatis. (2111 aa)
	mmpL	MmpL protein; Identified by match to protein family HMM PF03176; match to protein family HMM TIGR00833. (1002 aa)
	fadD28	acyl-CoA synthase; Identified by match to protein family HMM PF00501. (569 aa)
	mfpA	Conserved hypothetical protein; When present on multicopy plasmids confers increased resistance to fluoroquinolone antibiotics such as ciprofloxacin and sparfloxacin but not the quinolone nalidixic acid. Forms a structure that exhibits size, shape and electrostatic similarity to B-form DNA; it may bind to DNA gyrase which is postulated to protect it from fluoroquinolones (By similarity). Belongs to the pentapeptide repeat protein family. (191 aa)
	lexA	LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (243 aa)
	ABK70529.1	Mycocerosic acid synthase; Identified by match to protein family HMM PF00106; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF00698; match to protein family HMM PF02801. (1826 aa)

Your Current Organism:

Mycolicibacterium smegmatis

NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABK70529.1	fadD28	MSMEG_6767	MSMEG_0411	Mycocerosic acid synthase; Identified by match to protein family HMM PF00106; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF00698; match to protein family HMM PF02801.	acyl-CoA synthase; Identified by match to protein family HMM PF00501.	0.967
ABK70529.1	mmpL	MSMEG_6767	MSMEG_0410	Mycocerosic acid synthase; Identified by match to protein family HMM PF00106; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF00698; match to protein family HMM PF02801.	MmpL protein; Identified by match to protein family HMM PF03176; match to protein family HMM TIGR00833.	0.625
ABK70529.1	pks5	MSMEG_6767	MSMEG_4727	Mycocerosic acid synthase; Identified by match to protein family HMM PF00106; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF00698; match to protein family HMM PF02801.	Mycocerosic acid synthase; Polyketide synthase involved in the biosynthesis of 2,4- dimethyl-2-eicosenoic acid, a lipid component of the lipooligosaccharides (LOS) which are not located at the bacterial surface but rather in deeper compartments of the cell envelope of M.smegmatis.	0.903
fadD28	ABK70529.1	MSMEG_0411	MSMEG_6767	acyl-CoA synthase; Identified by match to protein family HMM PF00501.	Mycocerosic acid synthase; Identified by match to protein family HMM PF00106; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF00698; match to protein family HMM PF02801.	0.967
fadD28	mmpL	MSMEG_0411	MSMEG_0410	acyl-CoA synthase; Identified by match to protein family HMM PF00501.	MmpL protein; Identified by match to protein family HMM PF03176; match to protein family HMM TIGR00833.	0.727
fadD28	pks5	MSMEG_0411	MSMEG_4727	acyl-CoA synthase; Identified by match to protein family HMM PF00501.	Mycocerosic acid synthase; Polyketide synthase involved in the biosynthesis of 2,4- dimethyl-2-eicosenoic acid, a lipid component of the lipooligosaccharides (LOS) which are not located at the bacterial surface but rather in deeper compartments of the cell envelope of M.smegmatis.	0.971
mmpL	ABK70529.1	MSMEG_0410	MSMEG_6767	MmpL protein; Identified by match to protein family HMM PF03176; match to protein family HMM TIGR00833.	Mycocerosic acid synthase; Identified by match to protein family HMM PF00106; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF00698; match to protein family HMM PF02801.	0.625
mmpL	fadD28	MSMEG_0410	MSMEG_0411	MmpL protein; Identified by match to protein family HMM PF03176; match to protein family HMM TIGR00833.	acyl-CoA synthase; Identified by match to protein family HMM PF00501.	0.727
mmpL	pks5	MSMEG_0410	MSMEG_4727	MmpL protein; Identified by match to protein family HMM PF03176; match to protein family HMM TIGR00833.	Mycocerosic acid synthase; Polyketide synthase involved in the biosynthesis of 2,4- dimethyl-2-eicosenoic acid, a lipid component of the lipooligosaccharides (LOS) which are not located at the bacterial surface but rather in deeper compartments of the cell envelope of M.smegmatis.	0.804
pks5	ABK70529.1	MSMEG_4727	MSMEG_6767	Mycocerosic acid synthase; Polyketide synthase involved in the biosynthesis of 2,4- dimethyl-2-eicosenoic acid, a lipid component of the lipooligosaccharides (LOS) which are not located at the bacterial surface but rather in deeper compartments of the cell envelope of M.smegmatis.	Mycocerosic acid synthase; Identified by match to protein family HMM PF00106; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF00698; match to protein family HMM PF02801.	0.903
pks5	fadD28	MSMEG_4727	MSMEG_0411	Mycocerosic acid synthase; Polyketide synthase involved in the biosynthesis of 2,4- dimethyl-2-eicosenoic acid, a lipid component of the lipooligosaccharides (LOS) which are not located at the bacterial surface but rather in deeper compartments of the cell envelope of M.smegmatis.	acyl-CoA synthase; Identified by match to protein family HMM PF00501.	0.971
pks5	mmpL	MSMEG_4727	MSMEG_0410	Mycocerosic acid synthase; Polyketide synthase involved in the biosynthesis of 2,4- dimethyl-2-eicosenoic acid, a lipid component of the lipooligosaccharides (LOS) which are not located at the bacterial surface but rather in deeper compartments of the cell envelope of M.smegmatis.	MmpL protein; Identified by match to protein family HMM PF03176; match to protein family HMM TIGR00833.	0.804