STRINGSTRING
ABK74231.1 ABK74231.1 PE35 PE35 nrdB nrdB whiB3 whiB3 ABK72366.1 ABK72366.1 ABK75495.1 ABK75495.1 sigH sigH rshA rshA katG katG katG-2 katG-2 acpP acpP ahpD ahpD ABK73033.1 ABK73033.1 soxR soxR katG-3 katG-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABK74231.1Alkylhydroperoxidase AhpD. (96 aa)
PE35PE family protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (Probable). Plays a role in DNA conjugation, in at least a donor strain. (97 aa)
nrdBRibonucleoside-diphosphate reductase, beta subunit; Probable oxidase that might be involved in lipid metabolism. Belongs to the ribonucleoside diphosphate reductase small chain family. R2-like ligand binding oxidase subfamily. (320 aa)
whiB3Transcription factor WhiB; A redox-sensitive transcriptional regulator. Maintains intracellular redox homeostasis by regulating catabolic metabolism and polyketide biosynthesis. Regulates expression of the redox buffer ergothioneine (ERG). In concert with myothiol (MSH), another redox buffer, responds to low pH leading to acid resistance. The apo- but not holo-form probably binds DNA (By similarity). (96 aa)
ABK72366.1Rubredoxin; Identified by match to protein family HMM PF00301; Belongs to the rubredoxin family. (57 aa)
ABK75495.1Rubredoxin; Identified by match to protein family HMM PF00301. (60 aa)
sigHRNA polymerase sigma-70 factor, family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released. This sigma factor is involved in heat shock and oxidative stress responses. (219 aa)
rshAAnti-sigma factor, family protein; A redox-regulated anti-sigma factor for cognate extracytoplasmic function (ECF) sigma factor SigH. ECF sigma factors are held in an inactive form by an anti-sigma factor (Probable). Overexpression leads to increased susceptibility to diamide. (101 aa)
katGCatalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. (748 aa)
katG-2Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (688 aa)
acpPAcyl carrier protein; Acyl carrier protein involved in meromycolate extension. (99 aa)
ahpDAlkylhydroperoxidase, AhpD family protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. (177 aa)
ABK73033.1Alkylhydroperoxidase AhpD core; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (148 aa)
soxRRedox-sensitive transcriptional activator SoxR; Identified by similarity to SP:P22538; match to protein family HMM PF00376; match to protein family HMM TIGR01950. (141 aa)
katG-3Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria. (739 aa)
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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