STRINGSTRING
relA relA ABK73836.1 ABK73836.1 dnaA dnaA whiB-2 whiB-2 atpA atpA pbpB pbpB ftsW ftsW ftsZ ftsZ aceA-2 aceA-2 ripA ripA whiA whiA dnaN dnaN ABK74968.1 ABK74968.1 aceA aceA tuf tuf rplP rplP rpoA rpoA whiB3 whiB3 hup hup ABK76147.1 ABK76147.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (797 aa)
ABK73836.1Identified by match to protein family HMM PF00795. (299 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). (504 aa)
whiB-2Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (118 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (548 aa)
pbpBPenicillin binding protein transpeptidase domain protein; Identified by match to protein family HMM PF00905; match to protein family HMM PF03717; Belongs to the transpeptidase family. (648 aa)
ftsWCell division protein FtsW; Identified by match to protein family HMM PF01098; match to protein family HMM TIGR02614; Belongs to the SEDS family. (568 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (385 aa)
aceA-2Isocitrate lyase; Identified by match to protein family HMM PF00463; match to protein family HMM TIGR01346. (769 aa)
ripASecreted cell wall-associated hydrolase; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan. Required for normal separation of daughter cells after cell division and for cell wall integrity (By similarity). (497 aa)
whiAConserved hypothetical protein; Involved in cell division and chromosome segregation. (321 aa)
dnaNDNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (397 aa)
ABK74968.1Chromosome condensation protein; Identified by match to protein family HMM PF02678; match to protein family HMM PF05726; Belongs to the pirin family. (324 aa)
aceAIsocitrate lyase; Identified by match to protein family HMM PF00463; match to protein family HMM TIGR01346. (428 aa)
tufTranslation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (396 aa)
rplPRibosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (138 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (350 aa)
whiB3Transcription factor WhiB; A redox-sensitive transcriptional regulator. Maintains intracellular redox homeostasis by regulating catabolic metabolism and polyketide biosynthesis. Regulates expression of the redox buffer ergothioneine (ERG). In concert with myothiol (MSH), another redox buffer, responds to low pH leading to acid resistance. The apo- but not holo-form probably binds DNA (By similarity). (96 aa)
hupDNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. (208 aa)
ABK76147.1DNA translocase FtsK; Identified by match to protein family HMM PF01580; Belongs to the FtsK/SpoIIIE/SftA family. (926 aa)
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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